The hOGG1 gene encodes a DNA glycosylase that excises 8-hydroxyguanine (oh 8 Gua)
from damaged DNA. Structural analyses of the hOGG1 gene and its transcripts were …

In Escherichia coli, the dinB gene is required for the SOS-induced λ untargeted
mutagenesis pathway and confers a mutator phenotype to the cell when the gene product is …

dinP is an Escherichia coli gene recently identified at 5.5 min of the genetic map, whose
product shows a similarity in amino acid sequence to the E. coli UmuC protein involved in DNA …

We report the cloning of a human homolog of the yeast OGG1 gene, which encodes a DNA
glycosylase that excises an oxidatively damaged form of guanine, 8-hydroxyguanine (also …

Purpose Gemcitabine is rapidly metabolized to its inactive metabolite, 2′,2′-difluorodeoxyuridine
(dFdU), by cytidine deaminase (CDA). We previously reported that a patient with …

The entire nucleotide sequence of the pil region of the IncI1 plasmid R64 was determined.
Analysis of the sequence indicated that 14 genes, designated pilI through pilV, are involved in …

The IncI1 plasmid R64 produces two kinds of sex pili: a thin pilus and a thick pilus. The thin
pilus, which belongs to the type IV family, is required only for liquid matings. Fourteen genes, …

Purpose: We investigated single-nucleotide polymorphisms of the cytidine deaminase gene
(CDA), which encodes an enzyme that metabolizes gemcitabine, to clarify the relationship …

Chromosome DNA is continuously exposed to various endogenous and exogenous
mutagens. Among them, oxidation is one of the most common threats to genetic stability, and …

CYP3A4, the major form of cytochrome P450 (P450) expressed in the adult human liver, is
involved in the metabolism of approximately 50% of commonly prescribed drugs. Several …