Human cytochrome P450 (CYP) isoforms involved in amiodaroneN-deethylation were identified,
and the relative contributions of these CYP isoforms were evaluated in different human …

Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated
to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of …

The concept of relative activity factor (RAF) to extrapolate data obtained with recombinant
cytochrome P450(CYP)s to human liver microsomes has been proposed. To evaluate the …

Azelastine, an antiallergy and antiasthmatic drug, has been reported to be metabolized
mainly to desmethylazelastine and 6-hydroxyazelastine in mammals. In the present study, the …

The number of Electronic Control Units (ECUs) installed in vehicles is increasing owing to
the implementation of automatic driving functions or advanced driver assistance systems. …

Although human enteroviruses are the most commonly identified causes of aseptic meningitis
in infants and children and are known to circulate worldwide, infection with these viruses is …

Frequent coral bleaching has drawn attention to the mechanisms of coral dinoflagellate
endosymbiosis. Owing to the difficulty of rearing corals in the laboratory, model symbiosis …

Coagulation factor XII (FXII) is an 80-kDa plasma glycoprotein, which initiates the intrinsic
pathway of blood coagulation reactions. FXII is autocleaved after the Arg353 residue upon …

To investigate the effect of elevation of liver glycogen synthase (GYS2) activity on glucose
and glycogen metabolism, we performed adenoviral overexpression of the mutant GYS2 with …

We investigated the effect of glucokinase activator (GKA) on glucose metabolism and β-cell
mass. We analyzed four mouse groups: wild-type mice and β-cell-specific haploinsufficiency …