Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice
The study herein determined the role of nuclear factor erythoid 2–related factor 2 (Nrf2) in the
pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep ob/…
pathogenesis of hepatic steatosis, insulin resistance, obesity, and type 2 diabetes. Lep ob/…
Accuracy of unenhanced MR imaging in the detection of axillary lymph node metastasis: study of reproducibility and reliability
AM Scaranelo, R Eiada, LM Jacks, SR Kulkarni… - Radiology, 2012 - pubs.rsna.org
Purpose To investigate the accuracy, reproducibility, and reliability of unenhanced magnetic
resonance (MR) imaging techniques for detecting metastatic axillary lymph nodes in …
resonance (MR) imaging techniques for detecting metastatic axillary lymph nodes in …
Fasting Induces Nuclear Factor E2-Related Factor 2 and ATP-Binding Cassette Transporters via Protein Kinase A and Sirtuin-1 in Mouse and Human
SR Kulkarni, AC Donepudi, J Xu, W Wei… - Antioxidants & redox …, 2014 - liebertpub.com
Aims: The purpose of this study was to determine whether 3′-5′-cyclic adenosine
monophosphate (cAMP)-protein kinase A (PKA) and Sirtuin-1 (SIRT1) dependent mechanisms …
monophosphate (cAMP)-protein kinase A (PKA) and Sirtuin-1 (SIRT1) dependent mechanisms …
UDP-glucuronosyltransferase expression in mouse liver is increased in obesity-and fasting-induced steatosis
J Xu, SR Kulkarni, L Li, AL Slitt - Drug Metabolism and Disposition, 2012 - ASPET
UDP-glucuronosyltransferases (Ugt) catalyze phase II conjugation reactions with glucuronic
acid, which enhances chemical polarity and the elimination from the body. Few studies have …
acid, which enhances chemical polarity and the elimination from the body. Few studies have …
[PDF][PDF] Sirtuin 1 activation alleviates cholestatic liver injury in a cholic acid–fed mouse model of cholestasis
SR Kulkarni, CJ Soroka, LR Hagey, JL Boyer - Hepatology, 2016 - Wiley Online Library
Sirtuin1 (Sirt1; mammalian homolog of Saccharomyces cerevisiae enzyme Sir2) is a
transcriptional and transactivational regulator of murine farnesoid X receptor (Fxr), which is the …
transcriptional and transactivational regulator of murine farnesoid X receptor (Fxr), which is the …
Pilot study of quantitative analysis of background enhancement on breast MR images: association with menstrual cycle and mammographic breast density
…, MC Carrillo, R Fleming, LM Jacks, SR Kulkarni… - Radiology, 2013 - pubs.rsna.org
Purpose To perform semiautomated quantitative analysis of the background enhancement (BE)
in a cohort of patients with newly diagnosed breast cancer and to correlate it with …
in a cohort of patients with newly diagnosed breast cancer and to correlate it with …
Incidence of breast cancer in patients with pure flat epithelial atypia diagnosed at core-needle biopsy of the breast
…, AM Scaranelo, H Moshonov, SR Kulkarni… - Annals of surgical …, 2013 - Springer
Purpose to determine the frequency of malignancy in subsequent breast excisions following
core-needle biopsy (CNB) diagnosis of pure flat epithelial atypia (pFEA) and to evaluate the …
core-needle biopsy (CNB) diagnosis of pure flat epithelial atypia (pFEA) and to evaluate the …
Deficiency in N rf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin‐deficient mice
J Xu, AC Donepudi, VR More, SR Kulkarni, L Li… - …, 2015 - Wiley Online Library
Objective To evaluate whether Nrf2 deficiency impacts insulin resistance and lipid
accumulation in liver and white adipose tissue. Methods Lep ob/ob mice (OB) with targeted Nrf2 …
accumulation in liver and white adipose tissue. Methods Lep ob/ob mice (OB) with targeted Nrf2 …
Bisphenol A sulfonation is impaired in metabolic and liver disease
Background Bisphenol A (BPA) is a widely used industrial chemical and suspected endocrine
disruptor to which humans are ubiquitously exposed. The liver metabolizes and facilitates …
disruptor to which humans are ubiquitously exposed. The liver metabolizes and facilitates …
Evaluation of apparent diffusion coefficient to predict grade, microinvasion, and invasion in ductal carcinoma in situ of the breast
…, C Chung, H Moshonov, N Miller, SR Kulkarni… - Academic radiology, 2015 - Elsevier
Rationale and Objectives To evaluate the role of apparent diffusion coefficient (ADC) in
distinguishing ductal carcinoma in situ (DCIS) grades and identifying microinvasive and/or …
distinguishing ductal carcinoma in situ (DCIS) grades and identifying microinvasive and/or …