The metabolism of the immunosuppressant FK-506 was shown to be catalyzed primarily by
cytochrome P450 isozymes of the P450 3A subfamily. Antibodies against rat P450 3A …

The disposition of L-694,458, a potent monocyclic β-lactam inhibitor of human leukocyte
elastase, was studied in male Sprague-Dawley rats and rhesus monkeys. After iv dosing, L-…

The in vitro and in vivo metabolism ofN-[1(R)-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2(S)-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide
(L-694,458) was …

… Kabalka, GW, Varma, RS, Jinaraj, VK, Huang, L, and Painter, S K. Synthesis of iodine-125
labelled. omega. -… Kabalka, GW, Varma, RS, Jinaraj, VK, Huang, L, & Painter, S K …

L-683,845 is an orally active inhibitor of human leukocyte elastase. Its disposition was
studied in rats and rhesus monkeys after dosing with a 3H- or 14C-labeled compound …

… The chemical and radiochemical purity of the products were determined by thin layer
chromatography using silica gel plates (250u, Whatman K-5). An authentic sample of the …

We present a single-cell based model for the growth and division of eucaryotic cells. The
fluid-elastic structure of the cells and extracellular matrix are represented within the framework …

Background Observational studies have reported a positive association between body
mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this …

Epidemiological studies have demonstrated associations between endometriosis and
certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid …

Black carbon (BC) deposited on snow and glacier surfaces can reduce albedo and lead to
accelerated melt. An ice core recovered from Guoqu glacier on Mt. Geladaindong and …