1 Parallel human and rat studies were carried out to confirm the previous suggestion of an
increased sensitivity to warfarin in old age. 2 The anticoagulant response to warfarin was …

… TA Baillie for helpful discussions on the mechanisms of inhibition of drug metabolism by …
Levy RH, Loiseau P, Guyot M, Blehaut HM, Tor J, Moreland TA: Michaelis-Menten kinetics of …

1 Plasma naloxone levels were determined by RIA over a period of 6–36 h in three groups
of neonates, (1) those given 35 microgram iv (n = 6), (2) those given 70 microgram iv (n = 6) …

Autism spectrum disorders (ASD) are associated with defects in neuronal connectivity and
are highly heritable. Genetic findings suggest that there is an overrepresentation of chromatin …

Recent developments in our knowledge of drug binding prompt the questions, in what
circumstances are measurements of free levels necessary, desirable or not warranted? Free level …

The metabolism of stiripentol (I), a new antiepileptic drug, was studied in healthy human
subjects. Following a single 1200-mg oral dose to one subject, 13 metabolites of I were detected …

The enantiomers of warfarin were reduced to warfarin alcohols on incubation with human
and rat liver and kidney cytosol. The metabolism was NADPH-dependent with NADH being …

Sodium valproate (VPA) was administered for 1 week (1 g bid) to seven epileptic patients
receiving chronic carbamazepine (CBZ) therapy. Steady‐state CBZ levels determined before …

Administration of drugs by the sublingual route provides rapid systemic absorption and
avoids first-pass metabolism. The purpose of the present study was to assess the …

1. Plasma ethanol concentrations were measured in 24 male volunteers for 9 h after a
single oral dose of 710 mg kg‐1. 2. The rate of decline of the plasma ethanol concentration (k0; …