Current regulatory guidances do not address specific study designs for in vitro and in vivo
drug‐drug interaction studies. There is a common desire by regulatory authorities and by …

Serum creatinine concentrations are widely used clinically as an index of renal function. In
stable normal or reduced renal function they are determined by the rate of creatinine …

When I first tried animal experimentation for the purpose of discovering the motion and
functions of the heart by actual inspection and not by other people's books, I found it so truly …

Current regulatory guidances do not address specific study designs for in vitro and in vivo
drug-drug interaction studies. There is a common desire by regulatory authorities and by …

The pharmacokinetics of the angiotensin II receptor antagonist losartan potassium and its
active carboxylic acid metabolite EXP3174 were characterized in 18 healthy male subjects …

METHODS To address this issue, we decided to focus on publications reporting oral
bioavailability results in one clinical pharmacology journal, namely, Clinical Pharmacology & …

In addition to its antiplatelet effect, aspirin has been reported to have fibrinolytic and
hypoprothrombinemic effects. The objective of this study was to investigate possible mechanisms …

The International Conference on Harmonization (ICH) E5 guidelines were developed to
provide a general framework for evaluating the potential impact of ethnic factors on the …

Heparin kinetics were determined in four normal subjects, each of whom received three
different doses (25, 50, and 75 units/kg body weight) by intravenous injection. Multiple blood …

Serum creatinine concentration is commonly used in conjunction with individual patient
characteristics (eg, age, sex, and body weight) in order to estimate creatinine clearance. Such …