Th1/Th2/Th17 and regulatory T‐cell paradigm in pregnancy

S Saito, A Nakashima, T Shima… - American journal of …, 2010 - Wiley Online Library
… The main producer of IL-17 in both peripheral blood and deciduas is CD4 + T cells, and IL-17-expressing
CD8 + T cells are rare (approximately 0.1%). CD14 + monocytes, CD56 dim …

[HTML][HTML] Induction of intestinal Th17 cells by segmented filamentous bacteria

II Ivanov, K Atarashi, N Manel, EL Brodie, T Shima… - Cell, 2009 - cell.com
… show here that colonization of the small intestine of mice with a single commensal microbe,
segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4 + T

[PDF][PDF] Th17 cell induction by adhesion of microbes to intestinal epithelial cells

…, T Nagamori, E Ishikawa, T Shima, T Hara… - Cell, 2015 - cell.com
… Recombinant SAA1 markedly enhanced the in vitro differentiation of naive CD4+ T cells
into Th17 cells mediated by CD11c+ cells, IL-6, and transforming growth factor b (TGF-b) (Figure …

Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance

…, A Shiozaki, Y Sasaki, A Nakashima, T Shima… - Seminars in …, 2007 - Springer
… In humans, only CD4 + CD25 high or CD25 bright T cells have an immunoregulation ability,
and CD4 + CD25 dim T cells are recognized as activating T cells [17]. We firstly reported that …

ATP drives lamina propria TH17 cell differentiation

K Atarashi, J Nishimura, T Shima, Y Umesaki… - Nature, 2008 - nature.com
… To investigate whether intestinal commensal bacteria are responsible for the generation
of lamina propria T H 17 cells, we evaluated the numbers of T H 17 cells in germ-free mice. …

Photocatalytic hydrogenation of propyne with water on small-particle titania: size quantization effects and reaction intermediates

M Anpo, T Shima, S Kodama… - Journal of Physical …, 1987 - ACS Publications
Conclusions The following conclusions emerge from this study:(1) Variations in the nature of
the adsorbed phase of NO depend on surface structure rather than on Pt dispersion.(2) NO …

[HTML][HTML] New paradigm in the role of regulatory T cells during pregnancy

S Tsuda, A Nakashima, T Shima, S Saito - Frontiers in immunology, 2019 - frontiersin.org
Semi-allogenic fetuses are not rejected by the maternal immune system because feto-maternal
tolerance induced by CD4 + CD25 + FoxP3 + regulatory T (Treg) cells is established …

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

…, M Lupșor-Platon, S Petta, T Shima, T Okanoue… - Gut, 2022 - gut.bmj.com
Objective Liver biopsy is still needed for fibrosis staging in many patients with non-alcoholic
fatty liver disease. The aims of this study were to evaluate the individual diagnostic …

[PDF][PDF] TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells

…, T Shima, S Takayanagi, S Urata, T Miyamoto… - Cell stem cell, 2010 - cell.com
… Here we identified T cell immunoglobulin mucin-3 (TIM-3) as a surface molecule expressed
on LSCs in most types of AML except for acute promyelocytic leukemia, but not on normal …

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

K Atarashi, T Tanoue, T Shima, A Imaoka, T Kuwahara… - Science, 2011 - science.org
… affect the number and function of mucosal T regs . We first examined the appearance of T
regs during mouse ontogeny. The frequency of Foxp3 + T regs in colonic and small intestinal (…