Drug biliary clearance (CL bile ) in vivo is among the most difficult pharmacokinetic
parameters to predict accurately and quantitatively because biliary excretion is influenced by …

Background Echocardiographic parameters to predict pulmonary capillary wedge pressure (PCWP)
in mitral regurgitation (MR) are not yet elucidated. We reported that PCWP could be …

… Taiji Miyake …

Objectives The aim of this study was to investigate the accuracy of pre–percutaneous coronary
intervention (PCI) predicted nonhyperemic pressure ratios (NHPRs) with actual post-PCI …

Establishing a technological platform for creating clinical compounds inhibiting intracellular
protein–protein interactions (PPIs) can open the door to many valuable drugs. Although …

The effect of application timing of metconazole on the control of Fusarium head blight (HFB)
and mycotoxin accumulation in wheat and barley was investigated. Single and double …

Background and Purpose Fraction metabolized (f m ) and fraction transported (f t ) are
important for understanding drug–drug interactions (DDIs) in drug discovery and development. …

Talaromyces sp. isolate KNB-422, isolated from a rice seedling, is a biofungicidal agent
effective against several seedborne pathogens of rice including Gibberella fujikuroi, which …

Background and Purpose P‐glycoprotein (P‐gp) exhibits a broad substrate specificity and
affects pharmacokinetics, especially intestinal absorption. However, prediction, in vivo, of P‐gp…

The sensitivity of the Fusarium graminearum species complex, the causal fungus of Fusarium
head blight, to metconazole was measured. The minimum inhibitory concentrations (MIC) …