Drug-induced liver injury (DILI) is of concern to the pharmaceutical industry, and reliable
preclinical screens are required. Previously, we established an in vitro bile acid–dependent …

Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA)
allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective …

Bile acid (BA) retention within hepatocytes is an underlying mechanism of cholestatic drug-induced
liver injury (DILI). We previously developed an assay using sandwich-cultured …

Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is
already widely adopted in clinical practice. On the other hand, the development of CAR-T-…

Genome-wide association studies indicate that several idiosyncratic adverse drug reactions
are highly associated with specific human leukocyte antigen (HLA) alleles. For instance, …

Drug-induced liver injury (DILI) can cause hepatic failure and result in drug withdrawal from
the market. It has host-related and compound-dependent mechanisms. Preclinical prediction …

Immune-mediated idiosyncratic drug toxicity (IDT) is a rare adverse drug reaction, potentially
resulting in death. Although genome-wide association studies suggest that the occurrence …

Inhibition of bile salt export pump (BSEP) causes hepatic accumulation of toxic bile acid (BA),
leading to hepatocyte death. We reported a sandwich-cultured hepatocyte (SCH)–based …

Anti-human immunodeficiency virus (HIV) drug abacavir (ABC) binds to the specific allele of
human leukocyte antigen (HLA-B*57:01) and activates CD8 + T cells by presenting altered …

The bile salt export pump (BSEP or Bsep) functions as an apical transporter to eliminate bile
acids (BAs) from hepatocytes into the bile. BSEP or Bsep inhibitors engender BA retention, …