Ketamine is known to provide analgesic effects without an anesthetic when administered in
a low dose. We previously reported that a tablet containing ketamine had analgesic effects in …

Various pharmacokinetic parameters—disposition half-life, t 1/2,z , metabolic clearance CL
m , volume of distribution V, intrinsic clearance of unbound drug CLu t , and unbound volume …

Ketamine is metabolized by cytochrome P450 (CYP) leading to production of pharmacologically
active products and contributing to drug excretion. We identified the CYP enzymes …

Population pharmacokinetic parameters of vancomycin (VCM) in Japanese adult patients
infected with methicillin-resistant Staphylococcus aureus (MRSA) were estimated using 1253 …

The relationships between plasma or brain concentrations and analgesic effects of both
buprenorphine(BN) and an active metabolite, norbuprenorphine(NBN), were investigated in rats…

An improved high‐performance liquid chromatographic method was developed for the
quantification of glycyrrhizin and its metabolites in human plasma. The improved method was …

The respiratory depression induced by buprenorphine and its active metabolite, norbuprenorphine
(NBN), was evaluated in rats by measurement of changes in respiratory rate and …

In this study, a high-performance liquid chromatographic method was developed for the
quantitative determination of erythromycin (EM), roxithromycin (RXM), and azithromycin (AZM) in …

The apparent volume of distribution-after distribution equilibrium and the ratio of distributive
tissue volume to the unbound fraction in the tissue (V T /fu T )of 10 weak basic drugs, ie, …

In order to evaluate the arrhythmogenic potency of macrolide antibiotics in a quantitative
manner, we analyzed the influence of clarithromycin (CAM), roxithromycin (RXM), and …