Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines

G Theyer, M Schirmböck, T Thalhammer… - The Journal of …, 1993 - Elsevier
The treatment of advanced metastatic prostate cancer by hormone manipulation or
orchiectomy is frequently followed by the appearance of hormone-insensitive and highly …

[PDF][PDF] Modulation of liver canalicular transport processes by the tyrosine‐kinase inhibitor genistein: Implications of genistein metabolism in the rat

…, G Hamilton, G Theyer, J Graf, T Thalhammer - …, 1997 - Wiley Online Library
Rat liver cells express the multispecific organic anion transporter (cmoat, cmrp, mrp2) and P‐glycoprotein
(Pgp) in their canalicular membranes, proteins that are homologous to the …

Metabolism of the anticancer drug flavopiridol, a new inhibitor of cyclin dependent kinases, in rat liver

…, EA Sausville, HH Sedlacek, J Graf, T Thalhammer - Life sciences, 1998 - Elsevier
Flavopiridol (FLAP) is a promising novel chemotherapeutic agent currently undergoing clinical
phase I trials. To examine hepatic metabolism and biliary disposition of FLAP we applied …

In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and …

B Hagenauer, A Salamon, T Thalhammer… - Drug metabolism and …, 2001 - ASPET
The metabolism of flavopiridol (FLAP), a novel anticancer drug currently undergoing clinical
development, was investigated in rat and human liver microsomes. In the presence of …

Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in …

J Zacherl, G Hamilton, T Thalhammer, M Riegler… - Cancer chemotherapy …, 1994 - Springer
The ability of the multidrug resistance modifiers R- and R,S-verapamil (VPL), cyclosporine A
(CsA) and its non-immunosuppressive derivative SDZ PSC 833 (PSC 833) to inhibit P-…

Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases

T Bachrich, T Thalhammer, W Jäger, P Haslmayer… - Hepatology, 2001 - Elsevier
Uridine diphosphate glucuronosyltransferase (UGT) was identified as an antigenic target in
a subgroup of liver-kidney microsomal autoantibodies and was termed LKM-3. To evaluate …

Angiogenesis stimulation in explanted hearts from patients pre-treated with intravenous prostaglandin E1

…, C Ekmekcioglu, B Stanek, T Thalhammer… - The Journal of heart and …, 2001 - Elsevier
BACKGROUND: Prostaglandin E 1 (PGE 1 ) is a potent vasodilator and induces
angiogenesis in animal tissues. Previous clinical studies demonstrated that PGE 1 improves …

Effect of hypertonic stress on liver cell volume, bile flow, and volume-regulatory K+ fluxes

P Haddad, T Thalhammer… - American Journal of …, 1989 - journals.physiology.org
Net hepatic uptake and release of K+ were studied in the isolated-perfused rat liver subjected
to a 10-min period of hyperosmotic stress by addition of 80 mM mannitol or sucrose to the …

Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport

T Thalhammer, V Stapf, L Gajdzik, J Graf - European Journal of …, 1994 - Elsevier
This study explores properties of P-glycoprotein dependent membrane transport in rat liver
with the use of acridine orange as the substrate. We studied the biliary secretion of the dye, …

Organic solvents increase membrane fluidity and affect bile flow and K+ transport in rat liver

T Thalhammer, R Kaschnitz, K Mittermayer… - Biochemical …, 1993 - Elsevier
Following the earlier observation that inhalation of volatile lipid solvents and of narcotic gases
causes cholestasis, we studied the effects of various organic solvents on bile flow, plasma …