Metabolic profiles of four drugs possessing diverse metabolic pathways (timolol, meloxicam,
linezolid, and XK469) were compared following incubations in both suspended …

The objective of this study was to identify the enzyme that metabolizes methadone in preterm
placentas. Microsomal fractions were obtained from preterm (17 to 34 weeks) placentas (…

The aim of this investigation is to identify and characterize the enzyme system responsible
for the N-demethylation of methadone in human preterm placentas. The metabolism of …

Results • For meloxicam, the primary metabolic pathway (oxidation of the methyl substituent
of the methylthiazole moiety) had been reported as nearly 70% of the dose in human …

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found
in 50–70% of malignant melanomas 1 . Pre-clinical studies have demonstrated that the B-…

… of Peter Stork; that of Hieronymus is exclusively the work of … the editions of Lyco and
Hieronymus that were prepared by … to publish new photographs of the Hieronymus epitaph (inv. Sk …

The aberrant activation of tyrosine kinases represents an important oncogenic mechanism,
and yet the majority of such events remain undiscovered. Here we describe a bead-based …

Although androgen receptor (AR)-mediated signaling is central to prostate cancer, the ability
to modulate AR signaling states is limited. Here we establish a chemical genomic approach …

To pursue a systematic approach to the discovery of functional connections among diseases,
genetic perturbation, and drug action, we have created the first installment of a reference …

A 1999 Chevrolet Silverado was converted to dedicated use of E85 (85% ethanol, 15%
gasoline) by a team of students from the University of Nebraska-Lincoln. The goal was to …