Structure-Based Optimization and Biological Evaluation of Potent and Selective MMP-7 Inhibitors for Kidney Fibrosis
…, S Tokura, S Wakabayashi, T Yahara… - Journal of Medicinal …, 2023 - ACS Publications
Matrix metalloproteinase-7 (MMP-7) has been shown to play important roles in pathophysiological
processes involved in the development/progression of diseases such as cancer and …
processes involved in the development/progression of diseases such as cancer and …
Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points
…, H Tabuse, Y Yasukawa, T Yahara… - Journal of Medicinal …, 2024 - ACS Publications
Matrix metalloproteinase-7 (MMP-7) has been shown to play an important role in pathophysiological
processes such as cancer and fibrosis. We previously discovered selective MMP-7 …
processes such as cancer and fibrosis. We previously discovered selective MMP-7 …
Organic cation transporter function in different in vitro models of human lung epithelium
JJ Salomon, JC Gausterer, T Yahara, K Hosoya… - European Journal of …, 2015 - Elsevier
Organic cation transporters (OCT) encoded by members of the solute carrier (SLC) 22
family of genes are involved in the disposition of physiological substrates and xenobiotics, …
family of genes are involved in the disposition of physiological substrates and xenobiotics, …
[HTML][HTML] Amino acid residues involved in the substrate specificity of TauT/SLC6A6 for taurine and γ-aminobutyric acid
T Yahara, M Tachikawa, S Akanuma… - Biological and …, 2014 - jstage.jst.go.jp
Taurine transporter (TauT/SLC6A6) is an “honorary” γ-aminobutyric acid (GABA) transporter
because of its low affinity for GABA. The sequence analysis of TauT implied the role of Gly57…
because of its low affinity for GABA. The sequence analysis of TauT implied the role of Gly57…
Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cells
T Yahara, M Tachikawa, S Akanuma… - Drug metabolism and …, 2010 - jstage.jst.go.jp
We have reported previously that taurine transporter (TauT) mediates g-aminobutyric acid (GABA)
as a substrate in a conditionally immortalized rat retinal capillary endothelial cell line (…
as a substrate in a conditionally immortalized rat retinal capillary endothelial cell line (…
Recommendation to exclude bile-duct-cannulated rats with hyperbilirubinemia for proper conduct of biliary drug excretion studies
…, Y Hasegawa, K Iwata, T Ichikawa, T Yahara… - Drug Metabolism and …, 2016 - ASPET
Hyperbilirubinemia (HB) is sometimes encountered following bile-duct cannulation in rats. It
possibly originates from the reduced functioning of multidrug resistance-associated protein …
possibly originates from the reduced functioning of multidrug resistance-associated protein …
Activity assessment of organic cation/carnitine transporters in A549 alveolar epithelial cells
JJ Salomon, T Yahara, K Hosoya, C Ehrhardt - 2011 - Wiley Online Library
Uptake and release of reported substrates via organic cation/carnitine transporters (OCT/Ns)
was studied in A549 monolayers in an attempt to investigate the role of OCT/Ns in alveolar …
was studied in A549 monolayers in an attempt to investigate the role of OCT/Ns in alveolar …
Characterisation Of Organic Cation/Carnitine Transporters In Human Alveolar Epithelial Cell Monolayers (A549)
JJ Salomon, T Yahara, K Hosoya… - … : LUNG EPITHELIAL ION …, 2011 - atsjournals.org
Characterisation Of Organic Cation/carnitine Transporters In Human Alveolar Epithelial Cell
Monolayers (a549) Page 1 / Poster Discussion C28 CHANNEL SURFING: LUNG …
Monolayers (a549) Page 1 / Poster Discussion C28 CHANNEL SURFING: LUNG …
[BOOK][B] Aquatic biodiversity conservation and ecosystem services
S Nakano, T Yahara, T Nakashizuka - 2016 - Springer
It has been commonly accepted that biological diversity is important as a natural resource and
also for functioning of the ecosystem which provides us with ecosystem services essential …
also for functioning of the ecosystem which provides us with ecosystem services essential …
Integrative observations and assessments
S Nakano, T Yahara, T Nakashizuka - 2014 - Springer
It has been commonly accepted that biological diversity is important as a natural resource and
for the functioning of the ecosystem that provides us with benefits essential for human well-…
for the functioning of the ecosystem that provides us with benefits essential for human well-…