Somatic stem cell depletion due to the accumulation of DNA damage has been implicated
in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in …

The class II α-isoform of phosphatidylinositol 3-kinase (PI3K-C2α) is localized in endosomes,
the trans-Golgi network and clathrin-coated vesicles; however, its functional role is not well …

Purpose Solute carrier OCTN1 (SLC22A4) is an orphan transporter, the physiologically
important substrate of which is still unidentified. The aim of the present study was to examine …

In the past decade, many long noncoding RNAs (lncRNAs) have been identified and their in
vitro functions defined, although in some cases their functions in vivo remain less clear. …

Interaction of foods with intestinal transporters has generally been ascribed to small molecules,
but recently, edible-plant-derived nanoparticles (NPs) have been suggested to affect …

Background Clinically used antidepressants suffer from various side effects. Therefore, we
searched for a safe antidepressant with minimal side effects among food ingredients that are …

The aim of this study was to establish a quantitative standard for the cellular composition in
seminiferous tubules at each stage of spermatogenesis in the mouse testis, and thereby …

Microphthalmia transcription factor (MITF) is a basic-helix-loop-helix-leucine zipper-type
transcription factor. The mutant mi and Mi wh alleles encode MITFs with deletion and alteration …

Tricellular tight junctions (tTJs) are specialized tight junctions (TJs) that seal the intercellular
space at tricellular contacts (TCs), where the vertices of three epithelial cells meet. Tricellulin …

We previously reported that hepatic stellate cells (HSCs) activated by angiotensin II (AngII)
facilitate stromal fibrosis and tumor progression in intrahepatic cholangiocarcinoma (ICC). …