Detection of cocrystal formation based on binary phase diagrams using thermal analysis
H Yamashita, Y Hirakura, M Yuda, T Teramura… - Pharmaceutical …, 2013 - Springer
Purpose Although a number of studies have reported that cocrystals can form by heating a
physical mixture of two components, details surrounding heat-induced cocrystal formation …
physical mixture of two components, details surrounding heat-induced cocrystal formation …
A comparison of pharmacokinetics between humans and monkeys
…, K Kadono, S Sakuda, S Terashita, T Teramura - Drug Metabolism and …, 2010 - ASPET
To verify the availability of pharmacokinetic parameters in cynomolgus monkeys, hepatic
availability (Fh) and the fraction absorbed multiplied by intestinal availability (FaFg) were …
availability (Fh) and the fraction absorbed multiplied by intestinal availability (FaFg) were …
Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans
…, K Tanaka, M Irie, S Terashita, T Teramura - Xenobiotica, 2011 - Taylor & Francis
We describe the preclinical and clinical pharmacokinetic profiles of FK3453 [6-(2-amino-4-phenylpyrimidin-5-yl)-2-isopropylpyridazin-3(2H)-one]
and the mechanism responsible for …
and the mechanism responsible for …
Prediction of human metabolism of FK3453 by aldehyde oxidase using chimeric mice transplanted with human or rat hepatocytes
…, K Nozaki, H Murai, S Terashita, T Teramura… - Drug Metabolism and …, 2012 - ASPET
During drug development, it is important to predict the activities of multiple metabolic
enzymes, not only cytochrome P450 (P450) but also non-P450 enzymes, such as conjugative …
enzymes, not only cytochrome P450 (P450) but also non-P450 enzymes, such as conjugative …
Quantitative prediction of intestinal metabolism in humans from a simplified intestinal availability model and empirical scaling factor
…, K Tabata, K Gato, S Terashita, T Teramura - Drug Metabolism and …, 2010 - ASPET
This study aimed to establish a practical and convenient method of predicting intestinal
availability (F g ) in humans for highly permeable compounds at the drug discovery stage, with a …
availability (F g ) in humans for highly permeable compounds at the drug discovery stage, with a …
Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys
…, K Yamano, S Terashita, K Tabata, T Teramura - Xenobiotica, 2014 - Taylor & Francis
Glucuronidation via UDP-glucuronosyltransferase (UGT) in the intestine has been reported
to influence the pharmacokinetics (PK) of drugs; however, information concerning the …
to influence the pharmacokinetics (PK) of drugs; however, information concerning the …
Quantitative prediction of intestinal glucuronidation of drugs in rats using in vitro metabolic clearance data
…, K Yamano, S Terashita, T Teramura - Drug metabolism and …, 2012 - Elsevier
UDP-glucuronosyltransferase (UGT) is highly expressed in the small intestine and catalyzes
the glucuronidation of small molecules, which may affect the oral bioavailability of drugs. …
the glucuronidation of small molecules, which may affect the oral bioavailability of drugs. …
Comparison of intestinal metabolism of CYP3A substrates between rats and humans: application of portal–systemic concentration difference method
…, Y Naritomi, S Terashita, K Tabata, T Teramura - Xenobiotica, 2014 - Taylor & Francis
Rats are frequently used in pharmacokinetic studies during drug discovery. However, there
is limited information regarding species differences in intestinal availability (F g ) between …
is limited information regarding species differences in intestinal availability (F g ) between …
Correlation of intrinsic in vitro and in vivo clearance for drugs metabolized by hepatic UDP-glucuronosyltransferases in rats
…, H Miura, H Murai, S Terashita, T Teramura - Drug metabolism and …, 2011 - jstage.jst.go.jp
A method for quantitatively predicting the hepatic clearance of drugs by UDP-glucuronosyltransferases
(UGTs) from in vitro data has not yet been established. We examined the …
(UGTs) from in vitro data has not yet been established. We examined the …
Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data
…, K Kadono, K Yamano, S Terashita, T Teramura - Drug Metabolism and …, 2012 - ASPET
We investigated whether the effects of intestinal glucuronidation on the first-pass effect can
be predicted from in vitro data for UDP-glucuronosyltransferase (UGT) substrates. Human in …
be predicted from in vitro data for UDP-glucuronosyltransferase (UGT) substrates. Human in …