Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

Q Chen, MS Kinch, TH Lin, K Burridge… - Journal of Biological …, 1994 - Elsevier
Integrins can function as signal-transducing receptors capable of modulating cell growth and
gene expression (Juliano, RL, and Haskill, S. (1993) J. Cell Biol. 120, 577-585; Hynes, RO (…

Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts

TH Lin, AE Aplin, Y Shen, Q Chen, M Schaller… - The Journal of cell …, 1997 - rupress.org
Integrin-mediated cell adhesion causes activation of MAP kinases and increased tyrosine
phosphorylation of focal adhesion kinase (FAK). Autophosphorylation of FAK leads to the …

[PDF][PDF] Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation

M Shi, TH Lin, KC Appell, LJ Berg - Immunity, 2008 - cell.com
Differentiation of naive CD4 + T cells into T helper type 1 (Th1) effector cells requires both T
cell receptor (TCR) signaling and cytokines such as interleukin-12 and interferon γ (IFN-γ). …

[HTML][HTML] Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells: a possible signaling role for the Syk tyrosine kinase

TH Lin, C Rosales, K Mondal, JB Bolen… - Journal of Biological …, 1995 - ASBMB
Activation of cytoplasmic tyrosine kinases is an important aspect of signal transduction
mediated by integrins. In the human monocytic cell line THP-1, either integrin-dependent cell …

Janus kinase inhibitors for the treatment of rheumatoid arthritis demonstrate similar profiles of in vitro cytokine receptor inhibition

ME Dowty, TH Lin, MI Jesson, M Hegen… - Pharmacology …, 2019 - Wiley Online Library
Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various
inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function intracellularly …

PF-06651600, a dual JAK3/TEC family kinase inhibitor

H Xu, MI Jesson, UI Seneviratne, TH Lin… - ACS chemical …, 2019 - ACS Publications
PF-06651600 was developed as an irreversible inhibitor of JAK3 with selectivity over the
other three JAK isoforms. A high level of selectivity toward JAK3 is achieved by the covalent …

Discovery of tyrosine kinase 2 (TYK2) inhibitor (PF-06826647) for the treatment of autoimmune diseases

…, JD Knafels, DW Lin, TH Lin… - Journal of Medicinal …, 2020 - ACS Publications
Tyrosine kinase 2 (TYK2) is a member of the JAK kinase family that regulates signal
transduction downstream of receptors for the IL-23/IL-12 pathways and type I interferon family, …

[HTML][HTML] Cell anchorage permits efficient signal transduction between ras and its downstream kinases

TH Lin, Q Chen, A Howe, RL Juliano - Journal of Biological Chemistry, 1997 - ASBMB
Cell anchorage strongly affects the signal transduction cascade initiated by peptide mitogens.
For both epidermal growth factor and platelet-derived growth factor, activation of the …

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl) …

…, JD Knafels, DC Limburg, D Lin, TH Lin… - Journal of medicinal …, 2018 - ACS Publications
Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory
cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of …

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for …

…, PT Symanowicz, L Li, L Wang, TH Lin… - Journal of medicinal …, 2018 - ACS Publications
Janus kinases (JAKs) are intracellular tyrosine kinases that mediate the signaling of numerous
cytokines and growth factors involved in the regulation of immunity, inflammation, and …