Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity

…, R Bai, GE Kissling, G Travlos, U Hoffler - Biology of …, 2010 - academic.oup.com
The prevalence of human obesity and related chronic disorders such as diabetes,
cardiovascular diseases, and cancer is rapidly increasing. Human studies have shown a direct …

[HTML][HTML] COVID-19 vaccine hesitancy in underserved communities of North Carolina

…, W Pilkington, L Brown, V Billings, U Hoffler… - PLoS …, 2021 - journals.plos.org
Background In the United States, underserved communities including Blacks and Latinx are
disproportionately affected by COVID-19. This study sought to estimate the prevalence of …

Diet-induced obesity is associated with hyperleptinemia, hyperinsulinemia, hepatic steatosis, and glomerulopathy in C57Bl/6J mice

U Hoffler, K Hobbie, R Wilson, R Bai, A Rahman… - Endocrine, 2009 - Springer
Obesity and obesity-related illnesses are global epidemics impacting the health of adults and
children. The purpose of the present work is to evaluate a genetically intact obese mouse …

Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect

BI Ghanayem, KL Witt, L El-Hadri, U Hoffler… - Biology of …, 2005 - academic.oup.com
Acrylamide is an animal carcinogen and probable human carcinogen present in appreciable
amounts in heated carbohydrate-rich foodstuffs. It is also a germ cell mutagen, inducing …

Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using cyp2e1-/-mice

BI Ghanayem, U Hoffler - Current drug metabolism, 2007 - ingentaconnect.com
Cytochromes P450 (CYPs) comprise a number of enzyme subfamilies responsible for the
oxidative metabolism of a wide range of therapeutic agents, environmental toxicants, mutagens…

Cytochrome P450 2E1 (CYP2E1) is the principal enzyme responsible for urethane metabolism: comparative studies using CYP2E1-null and wild-type mice

U Hoffler, HA El-Masri, BI Ghanayem - Journal of Pharmacology and …, 2003 - ASPET
Urethane ([carbonyl- 14 C]ethyl carbamate) is a fermentation by-product in alcoholic beverages
and foods and is classified as reasonably anticipated to be a human carcinogen. Early …

Inhibition of urethane-induced genotoxicity and cell proliferation in CYP2E1-null mice

U Hoffler, D Dixon, S Peddada, BI Ghanayem - … Research/Fundamental and …, 2005 - Elsevier
Urethane is a multi-site animal carcinogen and was classified as “reasonably anticipated to
be a human carcinogen.” Urethane is a fermentation by-product and found at appreciable …

[PDF][PDF] COVID-19 testing and barriers to vaccine hesitancy in the Lumbee Tribe of North Carolina

…, P Strickland, WF Pilkington, U Hoffler… - North Carolina …, 2021 - academia.edu
During the COVID-19 pandemic, the North Carolina Central University Advanced Center for
COVID-19 Related Disparities (ACCORD), the Lumbee Tribe of North Carolina, and the …

Increased bioaccumulation of urethane in CYP2E1-/-versus CYP2E1+/+ mice

U Hoffler, BI Ghanayem - Drug metabolism and disposition, 2005 - ASPET
Urethane is a fermentation by-product and a potent animal carcinogen. Human exposure to
urethane occurs through consumption of alcoholic beverages and fermented foods. Recently…

Stress First Aid for Health-care Workers: An Indicated Mental Illness Prevention Program for Nursing Education

SP Convoy, M Heflin, BM Alston, U Hoffler… - Nursing …, 2023 - nursing.theclinics.com
According to a survey published by Mental Health America and funded by the Johnson &
Johnson Foundation, 93% of health-care workers are experiencing clinically significant and …