User profiles for V W Pike

Victor W Pike

Chief of PET Radiopharmaceutical Sciences
Verified email at mail.nih.gov
Cited by 23248

PET radiotracers: crossing the blood–brain barrier and surviving metabolism

VW Pike - Trends in pharmacological sciences, 2009 - cell.com
Radiotracers for imaging protein targets in the living human brain with positron emission
tomography (PET) are increasingly useful in clinical research and in drug development. Such …

Chemistry with [18F]Fluoride Ion

L Cai, S Lu, VW Pike - European Journal of Organic Chemistry, 2008 - Wiley Online Library
The success of molecular imaging with positron‐emission tomography (PET) depends on
the availability of selective molecular probes labeled with positron‐emitters, such asfluorine‐…

Consensus nomenclature rules for radiopharmaceutical chemistry—Setting the record straight

…, JM Jeong, RH Mach, TL Mindt, VW Pike… - Nuclear medicine and …, 2017 - Elsevier
Over recent years, within the community of radiopharmaceutical sciences, there has been an
increased incidence of incorrect usage of established scientific terms and conventions, and …

Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers

…, CT Li, GE Terry, SS Zoghbi, C Morse, VW Pike… - Molecular …, 2012 - nature.com
Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …

Mixed-affinity binding in humans with 18-kDa translocator protein ligands

…, M Fujita, WC Kreisl, RB Innis, VW Pike… - Journal of nuclear …, 2011 - Soc Nuclear Med
11 C-PBR28 PET can detect the 18-kDa translocator protein (TSPO) expressed within
macrophages. However, quantitative evaluation of the signal in brain tissue from donors with …

In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease

…, N Kimura, W Corona, CL Morse, SS Zoghbi, VW Pike… - Brain, 2013 - academic.oup.com
Neuroinflammation is a pathological hallmark of Alzheimer’s disease, but its role in cognitive
impairment and its course of development during the disease are largely unknown. To …

Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H] WAY-100635 and [11C] way-100635

H Hall, C Lundkvist, C Halldin, L Farde, VW Pike… - Brain research, 1997 - Elsevier
The distribution of 5-HT 1A receptors was examined in the post-mortem human brain using
whole hemisphere autoradiography and the selective 5-HT 1A receptor antagonist [ 3 H]WAY-…

Comparison of [11C]-(R)-PK 11195 and [11C] PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: implications for positron emission …

…, SS Zoghbi, RL Gladding, S Jacobson, U Oh, VW Pike… - Neuroimage, 2010 - Elsevier
Ten percent of humans lack specific binding of [ 11 C]PBR28 to 18 kDa translocator protein (TSPO),
a biomarker for inflammation. “Non-binders” have not been reported using another …

Tracer kinetic modeling of the 5-HT1AReceptor ligand [carbonyl-11C] WAY-100635 for PET

…, CJ Bench, EA Rabiner, S Osman, VW Pike… - Neuroimage, 1998 - Elsevier
[Carbonyl- 11 C]WAY-100635 is a promising PET radioligand for the 5-HT 1A receptor,
having demonstrated more favorable characteristics forin vivoimaging than the previously …

A Genetic Polymorphism for Translocator Protein 18 Kda Affects both in Vitro and in Vivo Radioligand Binding in Human Brain to this Putative Biomarker of …

…, T Hyde, JE Kleinman, VW Pike… - Journal of Cerebral …, 2013 - journals.sagepub.com
Second-generation radioligands for translocator protein (TSPO), an inflammation marker,
are confounded by the codominant rs6971 polymorphism that affects binding affinity. The …