Although some pharmaceutical company efforts to develop and distribute drugs in developing
countries have been successful, many fall short of meeting needs in resource-poor nations…

In this study, we have characterized the metabolism, tissue disposition, excretion routes,
and plasma pharmacokinetics of recombinant human nerve growth factor after single and …

The livers of 15 rabbits were perfused in situwith prednisone (PO) or prednisolone (POH)
over a wide range of steady state concentrations, resulting in multiple experimental …

The interconversion and elimination of prednisone (PO) and prednisolone (POH) were
examined in human and rabbit liver, kidney, lung and skeletal muscle preparations to determine …

Appreciated for their outstanding therapeutic potential, biotechnology products are currently
developed by both biotechnology and pharmaceutical firms. These two industries develop …

Special acknowledgements go to Lolin Ip for her outstanding technical assistance in all
aspects of the project. Past collaborators Margareta Hammarlund-Udenaes, Tove Tuntland and …

EVERY year the weather is in some sense abnormal, but the past twelve months have given
us rather more than our fair share of extremes, beginning with the most severe winter since …

SIR—Your News story about the recent clinical-trial disaster,“Can super-antibody drugs be
tamed?”(Nature 440, 855–856; 2006), reports TeGenero founder Thomas Hünig as saying …

Acute leukemia is the most common childhood cancer diagnosis and leading cause of
cancer-related death among children and adolescents. Despite substantial improvements in the …

Quantitative microbial risk assessment models for estimating the annual risk of enteric virus
infection associated with consuming raw vegetables that have been overhead irrigated with …