Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates numerous
cellular processes, including metabolism, proliferation, and cell survival. Due to its …

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that serves as an important
regulator of a broad range of cellular functions. It has been linked to Alzheimer’s disease …

Detailed metabolic characterization of 8, an earlier lead pyrazinone-based corticotropin-releasing
factor-1 (CRF 1 ) receptor antagonist, revealed that this compound formed significant …

Adaptor protein 2-associated kinase 1 (AAK1) is a serine/threonine kinase that was identified
as a therapeutic target for the potential treatment of neuropathic pain. Inhibition of AAK1 in …

Effective treatment of chronic pain, in particular neuropathic pain, without the side effects
that often accompany currently available treatment options is an area of significant unmet …

A series of pyrazinone-based heterocycles was identified as potent and orally active
corticotropin-releasing factor-1 (CRF 1 ) receptor antagonists. Selected compounds proved …

Evidence suggests that corticotropin-releasing factor-1 (CRF 1 ) receptor antagonists may
offer therapeutic potential for the treatment of diseases associated with elevated levels of CRF …

A series of N 3 -pyridylpyrazinones was investigated as corticotropin-releasing factor-1
receptor antagonists. It was observed that the binding affinity of analogues containing a pyridyl …

(S)-5-Chloro-1-(1-cyclopropylethyl)-3-(2,6-dichloro-4-(trifluoromethyl)phenylamino)pyrazin-2(1H)-one
(BMS-665053), a pyrazinone-containing compound, is a potent and selective …

A growing body of evidence suggests that CRF 1 receptor antagonism offers considerable
therapeutic potential in the treatment of diseases resulting from elevated levels of CRF, such …