A reliable translation of in vitro and preclinical data on drug absorption, distribution, metabolism,
and excretion (ADME) to humans is important for safe and effective drug development. …

Background Atopic dermatitis (AD) is a common skin disease affecting up to 20% of the global
population, with significant clinical heterogeneity and limited information about molecular …

Transporter-mediated drug-drug interactions (DDIs) are assessed using probe drugs and in
vitro and in vivo models during drug development. The utility of endogenous metabolites as …

Testosterone exhibits high variability in pharmacokinetics and glucuronidation after oral
administration. Although testosterone metabolism has been studied for decades, the impact of …

The glutamine antagonist 6-diazo-5-oxo-l-norleucine (DON) exhibits remarkable anticancer
efficacy; however, its therapeutic potential is hindered by its toxicity to gastrointestinal (GI) …

Tubular secretion is a primary mechanism along with glomerular filtration for renal elimination
of drugs and toxicants into urine. Organic cation transporters (OCTs) and multidrug and …

Poor and variable oral bioavailability of furosemide (FUR) presents critical challenges in
pharmacotherapy. We investigated the interplay of breast cancer resistance protein (Bcrp)-…

Interventions to decrease inflammation and improve metabolic function hold promise for the
prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally …

The placenta is a vital fetal organ that plays an important role in maintaining fetal sex hormone
homeostasis. Xenobiotics can alter placental sex-steroidogenic enzymes and transporters…

Repaglinide is type 2 short acting anti-diabetic drug which is primarily metabolized by CYP2C8
and CYP3A4 and is also a substrate of influx transporter OATP1B1. HIV drugs are potent …