Metabolism of the antioxidant butylated hydroxytoluene (BHT; 2,6-di-tert-butyl-4-methylphenol)
has been studied with liver and lung microsomes from rats and mice. The structures of …

While the immune microenvironment has been investigated in breast cancers, little is known
about its role in non-malignant breast tissues. Here we quantify and localize cellular …

Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen
increases lung tumor multiplicity in some inbred strains of mice. We report that BALB/…

Primary pleomorphic rhabdomyosarcoma of the uterus is a very rare neoplasm. We describe
a 65-year old female with this diagnosis, who underwent an abdominal hysterectomy with …

Inhibition of cyclooxygenase (COX) activity decreases eicosanoid production and prevents
lung cancer in animal models. Prostaglandin (PG) I 2 (PGI 2 , prostacyclin) is a PGH 2 …

To clarify the radical-scavenging activity of butylated hydroxytoluene (BHT), a food additive,
stoichiometric factors (n) and inhibition rate constants (k inh ) were determined for 2,6-di-tert-…

Long-term usage of the selective estrogen receptor modulator (SERM) tamoxifen has been
associated with an increased risk of endometrial cancer. One potential mechanism of …

DNA damage by metabolites of a food additive, butylated hydroxytoluene (BHT), was investigated
as a potential mechanism of carcinogenicity. The mechanism of DNA damage by 2,6-di…

Sphingobium xenophagum Bayram is capable of metabolizing 4‐alkoxyphenols and
endocrine disruptive α‐quaternary 4‐nonylphenols by an ipso‐substitution mechanism that …

Publisher Summary This chapter focuses on the role of quinoids in the DNA damage
induced by estrogens and antiestrogen metabolites. Selective estrogen receptor modulators (…