The taxanes paclitaxel and docetaxel represent a novel class of antlneoplastic agents. A
major problem of both drugs is their low aqueous solubility and the design of suitable …

In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause
multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins …

Life‐style has a major influence on the incidence of breast cancer. To evaluate the effects of
life‐style related metabolic‐endocrine factors on breast cancer risk we conducted a case‐…

Studies in humans and mice have demonstrated a nonlinear pharmacokinetic behavior of
paclitaxel. Because of its poor water solubility, the drug is formulated in a mixture of …

The non-linear plasma pharmacokinetics of paclitaxel in patients has been well established,
however, the exact underlying mechanism remains to be elucidated. We have previously …

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein
substrate drugs. We show here a 10-fold increased oral bioavailability of …

So far, all animal pharmacokinetic studies of paclitaxel, which used analytical procedures
based on HPLC, have not been sensitive enough to quantify drug levels below 500 ng/ml. …

Background: P-glycoprotein (Pgp) is a membrane protein that acts as an extrusion pump for
many cytotoxic drugs. Pgp is expressed in normal tissues, and its (over)expression in tumor …

We have developed and validated an analytical methodology for the quantification of
docetaxel and its four major human oxidation metabolites in mouse plasma. We have used this …

Purpose To determine the feasibility, toxicity, and immunologic effects of vaccination with
autologous tumor cells retrovirally transduced with the GM-CSF gene, we performed a …