[HTML][HTML] DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain

T Takizawa, K Nakashima, M Namihira, W Ochiai… - Developmental cell, 2001 - cell.com
Astrocyte differentiation, which occurs late in brain development, is largely dependent on
the activation of a transcription factor, STAT3. We show that astrocytes, as judged by glial …

BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis

K Nakashima, T Takizawa, W Ochiai… - Proceedings of the …, 2001 - National Acad Sciences
We show that when telencephalic neural progenitors are briefly exposed to bone morphogenetic
protein 2 (BMP2) in culture, their developmental fate is changed from neuronal cells to …

Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor

…, T Takizawa, M Yanagisawa, W Ochiai… - Experimental …, 2004 - Elsevier
Spontaneous recovery after spinal cord injury is limited. Transplantation of neural precursor
cells (NPCs) into lesioned adult rat spinal cord results in only partial functional recovery, and …

[HTML][HTML] Anti-obesity and anti-diabetic effects of acacia polyphenol in obese diabetic KKAy mice fed high-fat diet

N Ikarashi, T Toda, T Okaniwa, K Ito, W Ochiai… - Evidence-Based …, 2011 - hindawi.com
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia meansii) is
rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. The present …

The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages

…, A Mimura, T Toda, M Ishii, W Ochiai… - American Journal …, 2011 - journals.physiology.org
The purpose of this study was to investigate the role of aquaporin3 (AQP3) in the colon in
the laxative effect of bisacodyl. After oral administration of bisacodyl to rats, AQP3, …

Enhanced gene activation by Notch and BMP signaling cross‐talk

T Takizawa, W Ochiai, K Nakashima… - Nucleic acids …, 2003 - academic.oup.com
The signaling systems of Notch and bone morphogenetic protein (BMP) are highly conserved
from flies to mammals and have been shown to be important in the development of …

Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb …

…, Y Kusunoki, M Ishii, H Ueda, W Ochiai… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Aquaporin-3 (AQP3) is expressed in mucosal epithelial
cells in the colon and is important for regulating fecal water content. We examined the role of …

[HTML][HTML] The inhibition of lipase and glucosidase activities by acacia polyphenol

N Ikarashi, R Takeda, K Ito, W Ochiai… - Evidence-Based …, 2011 - hindawi.com
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia mearnsii) is
rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. In an in vitro …

Inhibition of aquaporin-3 water channel in the colon induces diarrhea

…, T Toda, M Ishii, M Hoshino, W Ochiai… - Biological and …, 2012 - jstage.jst.go.jp
Aquaporin (AQP) 3, which is predominantly expressed in the colon, is considered to play an
important role in regulating the fecal water content in the colon. In this study, the role of …

Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells

W Ochiai, S Nakatani, T Takahara, M Kainuma… - Molecular and Cellular …, 2009 - Elsevier
To understand the cellular and molecular mechanisms regulating cytogenesis within the
neocortical ventricular zone, we examined at high resolution the spatiotemporal expression …