Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors evaluated …

Context Hippocampal volume is lower than expected in patients with schizophrenia; however,
whether this represents a fixed deficit is uncertain. Exercise is a stimulus to hippocampal …

The psychostimulant methamphetamine (MA) is a highly addictive drug that has surged in
popularity over the last decade in North America. A burgeoning number of clandestine drug …

Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic
etiology. Despite this, prior attempts to localize susceptibility loci have produced …

Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients
with Alzheimer's disease. We measured the concentrations of two glucose transporters, …

Whether hippocampal neurogenesis persists throughout life in the human brain is not fully
resolved. Here, we demonstrate that hippocampal neurogenesis is persistent through the …

Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects
the monoamine neurotransmitter systems of the brain and results in feelings of alertness, …

Background The treatment of schizophrenia with multiple antipsychotic drugs is common,
but the benefits and risks are not known. Methods In a randomized, double-blind study, we …

Objective The pathologic indices of Alzheimer disease, cerebrovascular disease, and Lewy
body disease accumulate in the brains of older persons with and without dementia, but the …

Background Synaptic degeneration is an early pathogenic event in Alzheimer’s disease,
associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers …