Multidrug resistance conferred to cancer cells is often mediated by the expression of efflux
transporter “pumps”. It is also believed that many of the same transporters are involved in drug …

Using a representative powder blend containing ibuprofen, the applicability of coating with
silica nanoparticles using a dry comilling process to effectively enhance flowability of …

Many boronic acid‐containing molecules are currently under investigation as possible
therapeutics. An increase in the knowledge of the physical and chemical properties of these …

The goal of this work was to quantitate ester formation between alkyl and aryl boronic acids
and vicinal-diols or 1,2-diols in aqueous solution. As used here, 1,2-diols includes polyols …

The purpose of this study was to determine the aqueous solubility of a model phenyl boronic
acid, 4-methoxybenzeneboronic acid, as a function of pH both in the absence and in the …

In this chapter the term “macromolecular prodrug” will refer to a type of therapeutic agent in
which multiple pharmacologically active small molecules (drugs) are covalently, yet reversibly…

The research described in this dissertation was undertaken in order to better understand the
formulation relevant properties of boronic acids. Many boronic acid containing molecules …

Lipid-based formulations (LBF) have emerged as an attractive formulation strategy to deliver
poorly water-soluble drug molecules. The final dosage form, which can be either a liquid or …

Mycophenolate mofetil (MMF) is an orally bioavailable prodrug of mycophenolic acid (MPA),
a potent immunosuppressive agent. MPA acts by inhibiting inosine monophosphate …

… Special thanks to William Marinaro, a first year graduate student in Dr. Stella's Laboratory,
for his help in dosing and preparing the plasma samples during the pharmacokinetic studies. …