User profiles for Xiaoyun Wu
Xiaoyun WuResearch Data Scientist, National Policing Institute Verified email at gmu.edu Cited by 427 |
Antibody neutralization and escape by HIV-1
X Wei, JM Decker, S Wang, H Hui, JC Kappes, X Wu… - Nature, 2003 - nature.com
Neutralizing antibodies (Nab) are a principal component of an effective human immune
response to many pathogens, yet their role in HIV-1 infection is unclear 1 , 2 , 3 , 4 , 5 , 6 . To gain …
response to many pathogens, yet their role in HIV-1 infection is unclear 1 , 2 , 3 , 4 , 5 , 6 . To gain …
[HTML][HTML] A next generation connectivity map: L1000 platform and the first 1,000,000 profiles
…, S Silver, X Wu, WN Zhao, W Read-Button, X Wu… - Cell, 2017 - Elsevier
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and
disease states are connected by virtue of common gene-expression signatures. Here, we …
disease states are connected by virtue of common gene-expression signatures. Here, we …
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
…, RB Arani, JM Kilby, MS Saag, X Wu… - Antimicrobial agents …, 2002 - Am Soc Microbiol
The synthetic peptide T-20 (enfuvirtide) represents the first of a new class of antiretroviral
compounds to demonstrate in vivo potency by targeting a step in viral entry. T-20 inhibits a …
compounds to demonstrate in vivo potency by targeting a step in viral entry. T-20 inhibits a …
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
…, S Chen, ZV Boskovic, S Javaid, C Huang, X Wu… - Nature, 2017 - nature.com
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120
CA Derdeyn, JM Decker, JN Sfakianos, X Wu… - Journal of …, 2000 - Am Soc Microbiol
T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency
virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion …
virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion …
Feature selection for text categorization on imbalanced data
Z Zheng, X Wu, R Srihari - ACM Sigkdd Explorations Newsletter, 2004 - dl.acm.org
A number of feature selection metrics have been explored in text categorization, among
which information gain (IG), chi-square (CHI), correlation coefficient (CC) and odds ratios (OR) …
which information gain (IG), chi-square (CHI), correlation coefficient (CC) and odds ratios (OR) …
An STS-based map of the human genome
…, C Rosenberg, MP Reeve-Daly, S Rozen, L Hui, X Wu… - Science, 1995 - science.org
A physical map has been constructed of the human genome containing 15,086 sequence-tagged
sites (STSs), with an average spacing of 199 kilobases. The project involved assembly …
sites (STSs), with an average spacing of 199 kilobases. The project involved assembly …
Non-negative matrix factorization on manifold
Recently non-negative matrix factorization (NMF) has received a lot of attentions in
information retrieval, computer vision and pattern recognition. NMF aims to find two non-negative …
information retrieval, computer vision and pattern recognition. NMF aims to find two non-negative …
Discovering the anticancer potential of non-oncology drugs by systematic viability profiling
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth-…
have been serendipitous. We sought to create a public resource containing the growth-…
Spectral clustering for multi-type relational data
Clustering on multi-type relational data has attracted more and more attention in recent
years due to its high impact on various important applications, such as Web mining, e-commerce …
years due to its high impact on various important applications, such as Web mining, e-commerce …