User profiles for Xiaoyun Wu

Xiaoyun Wu

Research Data Scientist, National Policing Institute
Verified email at gmu.edu
Cited by 427

Antibody neutralization and escape by HIV-1

X Wei, JM Decker, S Wang, H Hui, JC Kappes, X Wu… - Nature, 2003 - nature.com
Neutralizing antibodies (Nab) are a principal component of an effective human immune
response to many pathogens, yet their role in HIV-1 infection is unclear 1 , 2 , 3 , 4 , 5 , 6 . To gain …

[HTML][HTML] A next generation connectivity map: L1000 platform and the first 1,000,000 profiles

…, S Silver, X Wu, WN Zhao, W Read-Button, X Wu… - Cell, 2017 - Elsevier
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and
disease states are connected by virtue of common gene-expression signatures. Here, we …

Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy

…, RB Arani, JM Kilby, MS Saag, X Wu… - Antimicrobial agents …, 2002 - Am Soc Microbiol
The synthetic peptide T-20 (enfuvirtide) represents the first of a new class of antiretroviral
compounds to demonstrate in vivo potency by targeting a step in viral entry. T-20 inhibits a …

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

…, S Chen, ZV Boskovic, S Javaid, C Huang, X Wu… - Nature, 2017 - nature.com
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer
therapies, thereby limiting their effectiveness 1 , 2 , 3 , 4 . A high-mesenchymal cell state …

Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120

CA Derdeyn, JM Decker, JN Sfakianos, X Wu… - Journal of …, 2000 - Am Soc Microbiol
T-20 is a synthetic peptide that potently inhibits replication of human immunodeficiency
virus type 1 by interfering with the transition of the transmembrane protein, gp41, to a fusion …

Feature selection for text categorization on imbalanced data

Z Zheng, X Wu, R Srihari - ACM Sigkdd Explorations Newsletter, 2004 - dl.acm.org
A number of feature selection metrics have been explored in text categorization, among
which information gain (IG), chi-square (CHI), correlation coefficient (CC) and odds ratios (OR) …

An STS-based map of the human genome

…, C Rosenberg, MP Reeve-Daly, S Rozen, L Hui, X Wu… - Science, 1995 - science.org
A physical map has been constructed of the human genome containing 15,086 sequence-tagged
sites (STSs), with an average spacing of 199 kilobases. The project involved assembly …

Non-negative matrix factorization on manifold

D Cai, X He, X Wu, J Han - 2008 eighth IEEE international …, 2008 - ieeexplore.ieee.org
Recently non-negative matrix factorization (NMF) has received a lot of attentions in
information retrieval, computer vision and pattern recognition. NMF aims to find two non-negative …

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

…, M Kocak, JG Bryan, R Humeidi, D Peck, X Wu… - Nature cancer, 2020 - nature.com
Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth-…

Spectral clustering for multi-type relational data

B Long, Z Zhang, X Wu, PS Yu - … of the 23rd international conference on …, 2006 - dl.acm.org
Clustering on multi-type relational data has attracted more and more attention in recent
years due to its high impact on various important applications, such as Web mining, e-commerce …