Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe
the endocannabinoid system and as novel pharmacotherapies, but are now highly abused. …

Metabolite identification plays a critical role in the phases during drug development. Drug
metabolites can contribute to efficacy, toxicity, and drug-drug interaction. Thus, the correct …

Regulating SOS1 functions may result in targeted pan-KRAS therapies. Small-molecule
SOS1 inhibitors showed promising anticancer potential, and the most advanced inhibitor BI …

3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral
ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and …

Rationale AMB (methyl (1‐pentyl‐1H‐indazole‐3‐carbonyl)‐L‐valinate)) and its fluoro analog
5F‐AMB (methyl (1‐(5‐fluoropentyl)‐1H‐indazole‐3‐carbonyl)‐L‐valinate) are two new …

BACKGROUND Despite increasing prevalence of novel psychoactive substances, no human
metabolism data are currently available, complicating laboratory documentation of intake …

Direct chemical modification of native antibodies in a site‐specific manner remains a great
challenge. Ligand‐directed conjugation can achieve the selective modification of antibodies, …

Background and Purpose Famitinib is a novel multi‐targeted receptor tyrosine kinase inhibitor
under development for cancer treatment. This study aims to characterize the metabolic …

Pyrotinib is a novel irreversible tyrosine kinase inhibitor developed for the treatment of human
epidermal growth factor receptor 2 (HER2)-positive breast cancer. The results of phase I …

Elemental sulfur-driven autotrophic denitrification (S 0 dAD) was applied in a packed-bed
reactor to remove residual nitrogen from raw mature landfill leachate after partial nitritation and …