A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

Y Matsumura, H Maeda - Cancer research, 1986 - AACR
We previously found that a polymer conjugated to the anticancer protein neocarzinostatin,
named smancs, accumulated more in tumor tissues than did neocarzinostatin. To determine …

Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery

…, N Yamada, T Ogura, MR Kano, Y Matsumura… - Nature …, 2016 - nature.com
Enhanced permeability in tumours is thought to result from malformed vascular walls with
leaky cell-to-cell junctions 1 , 2 . This assertion is backed by studies using electron microscopy …

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

H Maeda, J Wu, T Sawa, Y Matsumura… - Journal of controlled …, 2000 - Elsevier
Most solid tumors possess unique pathophysiological characteristics that are not observed
in normal tissues or organs, such as extensive angiogenesis and hence hypervasculature, …

Preclinical and clinical studies of anticancer agent‐incorporating polymer micelles

Y Matsumura, K Kataoka - Cancer science, 2009 - Wiley Online Library
The size of anticancer agent‐incorporating micelles can be controlled within the diameter
range of 20–100 nm to ensure that they do not penetrate normal vessel walls. With this …

Significance of CD44 gene products for cancer diagnosis and disease evaluation

Y Matsumura, D Tarin - The Lancet, 1992 - Elsevier
With increasing emphasis on the early detection of cancer, the search is on for reliable markers
that will be clinically helpful in the diagnosis of small tumours and in the assessment of …

Cancer stromal targeting (CAST) therapy

Y Matsumura - Advanced drug delivery reviews, 2012 - Elsevier
Despite great advances in cell and molecular biology, pharmacology and medicine, there is
to date no antitumor drug available which can specifically kill tumor cells in the human body …

Toxic effects of ultraviolet radiation on the skin

Y Matsumura, HN Ananthaswamy - Toxicology and applied pharmacology, 2004 - Elsevier
Ultraviolet (UV) irradiation present in sunlight is an environmental human carcinogen. The
toxic effects of UV from natural sunlight and therapeutic artificial lamps are a major concern for …

Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice

…, Y Kato, Y Sugiyama, K Nishio, Y Matsumura… - Cancer research, 2003 - AACR
Polymeric micelles incorporating cisplatin (CDDP) were prepared through the polymer-metal
complex formation between CDDP and poly(ethylene glycol)-poly(glutamic acid) block …

Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled …

…, S Fukushima, H Koyama, M Yasuhiro… - Bioconjugate …, 2005 - ACS Publications
A novel intracellular pH-sensitive polymeric micelle drug carrier that controls the systemic,
local, and subcellular distributions of pharmacologically active drugs has been developed in …

[HTML][HTML] NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel

T Hamaguchi, Y Matsumura, M Suzuki… - British journal of …, 2005 - nature.com
Paclitaxel (PTX) is one of the most effective anticancer agents. In clinical practice, however,
high incidences of adverse reactions of the drug, for example, neurotoxicity, …