User profiles for Yasuhiro Tateishi
Yasuhiro TateishiVanderbilt University, Postdoctral Scholar Verified email at vanderbilt.edu Cited by 72 |
[HTML][HTML] Stepwise binding of inhibitors to human cytochrome P450 17A1 and rapid kinetics of inhibition of androgen biosynthesis
…, KD McCarty, JG Chapman, Y Tateishi - Journal of Biological …, 2021 - ASBMB
Cytochrome P450 (P450) 17A1 catalyzes the 17α-hydroxylation of progesterone and
pregnenolone as well as the subsequent lyase cleavage of both products to generate androgens. …
pregnenolone as well as the subsequent lyase cleavage of both products to generate androgens. …
Development of novel diclofenac analogs designed to avoid metabolic activation and hepatocyte toxicity
Y Tateishi, T Ohe, M Ogawa, K Takahashi… - ACS …, 2020 - ACS Publications
Diclofenac (DCF) is widely used as a nonsteroidal anti-inflammatory drug; however, it is
associated with severe liver injury. This adverse reaction is thought to be related to the reactive …
associated with severe liver injury. This adverse reaction is thought to be related to the reactive …
Synthesis and evaluation of nevirapine analogs to study the metabolic activation of nevirapine
Y Tateishi, T Ohe, D Yasuda, K Takahashi… - Drug Metabolism and …, 2020 - Elsevier
Nevirapine (NVP) is widely used as a non-nucleoside reverse transcriptase inhibitor of HIV-1,
however, it is associated with severe skin and liver injury. The mechanisms of these …
however, it is associated with severe skin and liver injury. The mechanisms of these …
[HTML][HTML] Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1
KD McCarty, ME Sullivan, Y Tateishi… - Journal of Biological …, 2023 - ASBMB
Cytochrome P450 (P450, CYP) family 51 enzymes catalyze the 14α-demethylation of sterols,
leading to critical products used for membranes and the production of steroids, as well as …
leading to critical products used for membranes and the production of steroids, as well as …
Oxygen‐18 Labeling Reveals a Mixed Fe− O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation
KD McCarty, Y Tateishi, TY Hargrove… - Angewandte …, 2024 - Wiley Online Library
The 14α‐demethylation step is critical in eukaryotic sterol biosynthesis, catalyzed by
cytochrome P450 (P450) Family 51 enzymes, for example, with lanosterol in mammals. This …
cytochrome P450 (P450) Family 51 enzymes, for example, with lanosterol in mammals. This …
[HTML][HTML] The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive
KD McCarty, L Liu, Y Tateishi… - Journal of Biological …, 2024 - ASBMB
Cytochrome P450 (P450, CYP) 11A1 is the classical cholesterol side chain cleavage enzyme
(P450 scc ) that removes six carbons of the side chain, the first and rate-limiting step in the …
(P450 scc ) that removes six carbons of the side chain, the first and rate-limiting step in the …
Characterization of impact damage resistance of CF/PEEK and CF/toughened epoxy laminates under low and high velocity impact tests
H Morita, T Adachi, Y Tateishi, H Matsumoto - 1995 - osti.gov
In order to use composite materials in aeronautical turbo engines, their resistance to impact
damage must be understood. In this work the subperforation flat-wise impact resistance of …
damage must be understood. In this work the subperforation flat-wise impact resistance of …
Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease
…, Y Ishikawa, K Furukawa, Y Tateishi… - Bioorganic & Medicinal …, 2021 - Elsevier
In the present study, we newly synthesized three types of novel fullerene derivatives:
pyridinium-type derivatives trans-3a and 4a-5b, piperidinium-type derivative 9, and proline-type …
pyridinium-type derivatives trans-3a and 4a-5b, piperidinium-type derivative 9, and proline-type …
Oxygen-18 Labeling Defines a Ferric Peroxide (Compound 0) Mechanism in the Oxidative Deformylation of Aldehydes by Cytochrome P450 2B4
Y Tateishi, KD McCarty, MV Martin… - ACS catalysis, 2024 - ACS Publications
Most cytochrome P450 (P450) oxidations are considered to occur with the active oxidant
being a perferryl oxygen (FeO 3+ , Compound I). However, a ferric peroxide (FeO 2 ̅ , …
being a perferryl oxygen (FeO 3+ , Compound I). However, a ferric peroxide (FeO 2 ̅ , …
3, 4-Desaturation of retinoic acid by cytochrome P450 27C1 prevents P450-mediated catabolism
Cytochrome P450 (P450, CYP) 27C1 is expressed in human skin and catalyzes the 3,4-desaturation
of retinoids. The enzyme has a relatively high specificity constant (k cat /K m ), and …
of retinoids. The enzyme has a relatively high specificity constant (k cat /K m ), and …