To understand the DNA recognition mechanism of zinc finger motifs of transcription factor
Sp1, we have determined the solution structure of DNA-binding domain of the Sp1 by solution …

Engineered cysteine residues are particularly convenient for site-specific conjugation of
antibody–drug conjugates (ADC), because no cell engineering and additives are required. …

Human transcription factor Sp1 contains three contiguous repeats of the C 2 H 2 -type zinc
finger motif and binds to the decanucleotide sequence 5′‐(G/T)GGGCGG(G/A)(G/A)(C/T)-3…

The addition of a new function to native proteins is one of the most attractive protein-based
designs. In this study, we have converted a C 2 H 2 -type zinc finger as a DNA-binding motif …

The site-specific chemical conjugation of proteins, following synthesis with an expanded
genetic code, promises to advance antibody-based technologies, including antibody drug …

Engineered cysteine residues are currently used for the site-specific conjugation of antibody–drug
conjugates (ADC). In general, positions on the protein surface have been selected for …

Carcinoembryonic antigen (CEA) is a classic tumor‐specific antigen that is overexpressed
in several cancers, including gastric cancer. Although some anti‐CEA antibodies have been …

The unique linker sequence of the native nine zinc finger transcription factor IIIA (TFIIIA)
appears to significantly affect its novel DNA recognition mode. An artificial new nine zinc finger …

The recent design strategy of zinc finger peptides has mainly focused on the α-helix region,
which plays a direct role in DNA recognition. On the other hand, the study of non-DNA-…

We have developed 10‐inch RGBW LCD with edge‐lit 2D local dimming backlight system
for automotive applications. This prototype system has power consumption reduction …