Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

D Fulton, JP Gratton, TJ McCabe, J Fontana, Y Fujio… - Nature, 1999 - nature.com
Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for
maintaining systemic blood pressure, vascular remodelling and angiogenesis 1 , 2 , 3 , 4 . …

Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies

M Zhang, D Methot, V Poppa, Y Fujio, K Walsh… - Journal of molecular and …, 2001 - Elsevier
M. Zhang, D. Methot, V. Poppa, Y. Fujio, K. Walsh and CE Murry. Cardiomyocyte Grafting for
Cardiac Repair: Graft Cell Death and Anti-Death Strategies. Journal of Molecular and …

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart

Y Fujio, T Nguyen, D Wencker, RN Kitsis, K Walsh - Circulation, 2000 - Am Heart Assoc
Background—IGF-1 has been shown to protect myocardium against death in animal models
of infarct and ischemia-reperfusion injury. In the present study, we investigated the role of …

[HTML][HTML] Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner

Y Fujio, K Walsh - Journal of Biological Chemistry, 1999 - ASBMB
Regulation of endothelial cell apoptosis is a critical modulator of normal and pathological
angiogenesis. In this study, we examined the role of the protein kinase Akt/PKB in endothelial …

[HTML][HTML] Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells

…, RW Alexander, M Akers, QQ Yin, Y Fujio… - Journal of Biological …, 1999 - ASBMB
Angiotensin II, a hypertrophic/anti-apoptotic hormone, utilizes reactive oxygen species (ROS)
as growth-related signaling molecules in vascular smooth muscle cells (VSMCs). Recently, …

Vascular endothelial growth factor–stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt

…, D Fulton, G Sowa, LR Languino, Y Fujio… - Circulation …, 2000 - Am Heart Assoc
Vascular endothelial growth factor (VEGF) induces endothelial cell proliferation, migration,
and actin reorganization, all necessary components of an angiogenic response. However, the …

Taurine depletion caused by knocking out the taurine transporter gene leads to cardiomyopathy with cardiac atrophy

…, M Ikawa, M Okabe, SW Schaffer, Y Fujio… - Journal of molecular and …, 2008 - Elsevier
The sulfur-containing β-amino acid, taurine, is the most abundant free amino acid in cardiac
and skeletal muscle. Although its physiological function has not been established, it is …

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

…, Y Yoshioka, Y Torisawa, H Date, Y Fujio… - Science …, 2022 - science.org
In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers to …

Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation …

S Negoro, K Kunisada, Y Fujio, M Funamoto… - Circulation, 2001 - Am Heart Assoc
Background Mice with cardiac-specific overexpression of signal transducer and activator of
transcription 3 (STAT3) are resistant to doxorubicin-induced damage. The STAT3 signal may …

Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon …

…, GZ Rassidakis, W Zhang, Y Fujio… - The American journal of …, 2005 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) has oncogenic potential. The
biological effects of STAT3 have not been studied extensively in the pathogenesis of colon …