Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a and -3b …
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a and -3b …
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation
…, K Sumida, T Sukata, Y Tomigahara… - Toxicological …, 2009 - academic.oup.com
Two-year treatment with high doses of Metofluthrin produced hepatocellular tumors in both
sexes of Wistar rats. To understand the mode of action (MOA) by which the tumors are …
sexes of Wistar rats. To understand the mode of action (MOA) by which the tumors are …
[HTML][HTML] A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice
K Higashi, Y Tomigahara, H Shiraki, K Miyata… - Journal of biological …, 2011 - ASBMB
Transforming growth factor-β (TGF-β) is considered to be a major factor contributing to liver
fibrosis. We have previously shown that nuclear translocation of YB-1 antagonizes the TGF-β/…
fibrosis. We have previously shown that nuclear translocation of YB-1 antagonizes the TGF-β/…
Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of …
…, M Kawabe, S Takahashi, Y Doi, Y Tomigahara… - Toxicology and Applied …, 2009 - Elsevier
To verify whether anti-androgens cause transgenerational effects on spermatogenesis and
DNA methylation in rats, gravid Crl:CD(SD) female rats (4 or 5/group, gestational day (GD) 0=…
DNA methylation in rats, gravid Crl:CD(SD) female rats (4 or 5/group, gestational day (GD) 0=…
A novel inhibitor of Smad‐dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis
…, M Horikawa, K Higashi, Y Tomigahara… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc),
and an increasing number of promising molecular targets for antifibrotic therapies have …
and an increasing number of promising molecular targets for antifibrotic therapies have …
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human …
…, H Nagahori, T Yamada, Y Deguchi, Y Tomigahara… - Toxicology, 2009 - Elsevier
High doses of Metofluthrin (MTF) have been shown to produce liver tumours in rats by a mode
of action (MOA) involving activation of the constitutive androstane receptor leading to liver …
of action (MOA) involving activation of the constitutive androstane receptor leading to liver …
Lack of Significant Estrogenic or Antiestrogenic Activity of Pyrethroid Insecticides in Three in Vitro Assays Based on Classic Estrogen Receptor α-Mediated …
K Saito, Y Tomigahara, N Ohe, N Isobe… - Toxicological …, 2000 - academic.oup.com
Estrogenic and antiestrogenic activity of pyrethroid insecticides (d-trans-allethrin, cypermethrin,
empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was …
empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was …
[PDF][PDF] Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation
…, Y Yasuda, D Hagiwara, S Iwama, Y Tomigahara… - Stem Cell Reports, 2023 - cell.com
Pituitary organoids are promising graft sources for transplantation in treatment of
hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic …
hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic …
Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer
K Harada, H Kubo, Y Tomigahara, K Nishioka… - Bioorganic & medicinal …, 2010 - Elsevier
The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17β-HSD3
inhibitors are discussed. The most potent compounds from this series exhibited low …
inhibitors are discussed. The most potent compounds from this series exhibited low …
Identification of metabolism and excretion differences of procymidone between rats and humans using chimeric mice: Implications for differential developmental …
J Abe, Y Tomigahara, H Tarui, R Omori… - Journal of agricultural …, 2018 - ACS Publications
A metabolite of procymidone, hydroxylated-PCM, causes rat-specific developmental toxicity
due to higher exposure to it in rats than in rabbits or monkeys. When procymidone was …
due to higher exposure to it in rats than in rabbits or monkeys. When procymidone was …