Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements

G Liang, MF Chan, Y Tomigahara, YC Tsai… - … and cellular biology, 2002 - Taylor & Francis
We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA
methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a and -3b …

Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation

…, K Sumida, T Sukata, Y Tomigahara… - Toxicological …, 2009 - academic.oup.com
Two-year treatment with high doses of Metofluthrin produced hepatocellular tumors in both
sexes of Wistar rats. To understand the mode of action (MOA) by which the tumors are …

[HTML][HTML] A novel small compound that promotes nuclear translocation of YB-1 ameliorates experimental hepatic fibrosis in mice

K Higashi, Y Tomigahara, H Shiraki, K Miyata… - Journal of biological …, 2011 - ASBMB
Transforming growth factor-β (TGF-β) is considered to be a major factor contributing to liver
fibrosis. We have previously shown that nuclear translocation of YB-1 antagonizes the TGF-β/…

Maternal exposure to anti-androgenic compounds, vinclozolin, flutamide and procymidone, has no effects on spermatogenesis and DNA methylation in male rats of …

…, M Kawabe, S Takahashi, Y Doi, Y Tomigahara… - Toxicology and Applied …, 2009 - Elsevier
To verify whether anti-androgens cause transgenerational effects on spermatogenesis and
DNA methylation in rats, gravid Crl:CD(SD) female rats (4 or 5/group, gestational day (GD) 0=…

A novel inhibitor of Smad‐dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis

…, M Horikawa, K Higashi, Y Tomigahara… - … : Official Journal of …, 2009 - Wiley Online Library
Objective Tissue fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc),
and an increasing number of promising molecular targets for antifibrotic therapies have …

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human …

…, H Nagahori, T Yamada, Y Deguchi, Y Tomigahara… - Toxicology, 2009 - Elsevier
High doses of Metofluthrin (MTF) have been shown to produce liver tumours in rats by a mode
of action (MOA) involving activation of the constitutive androstane receptor leading to liver …

Lack of Significant Estrogenic or Antiestrogenic Activity of Pyrethroid Insecticides in Three in Vitro Assays Based on Classic Estrogen Receptor α-Mediated …

K Saito, Y Tomigahara, N Ohe, N Isobe… - Toxicological …, 2000 - academic.oup.com
Estrogenic and antiestrogenic activity of pyrethroid insecticides (d-trans-allethrin, cypermethrin,
empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was …

[PDF][PDF] Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation

…, Y Yasuda, D Hagiwara, S Iwama, Y Tomigahara… - Stem Cell Reports, 2023 - cell.com
Pituitary organoids are promising graft sources for transplantation in treatment of
hypopituitarism. Building on development of self-organizing culture to generate pituitary-hypothalamic …

Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

K Harada, H Kubo, Y Tomigahara, K Nishioka… - Bioorganic & medicinal …, 2010 - Elsevier
The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17β-HSD3
inhibitors are discussed. The most potent compounds from this series exhibited low …

Identification of metabolism and excretion differences of procymidone between rats and humans using chimeric mice: Implications for differential developmental …

J Abe, Y Tomigahara, H Tarui, R Omori… - Journal of agricultural …, 2018 - ACS Publications
A metabolite of procymidone, hydroxylated-PCM, causes rat-specific developmental toxicity
due to higher exposure to it in rats than in rabbits or monkeys. When procymidone was …