The retinoids are a class of compounds that are structurally related to vitamin A. Retinoic
acid, which is the active metabolite of retinol, regulates a wide range of biological processes …

A large number of physiological processes in the adult liver are regulated by nuclear receptors
that require heterodimerization with retinoid X receptors (RXRs). In this study, we have …

AIM: To investigate Fusobacterium nucleatum (F. nucleatum) abundance in colorectal cancer
(CRC) tissues and its association with CRC invasiveness in Chinese patients. METHODS: …

BACKGROUND: The short (S) allele of the serotonin transporter gene-linked polymorphic
region (5HTTLPR) has been associated with poorer antidepressant response in major …

Carboxylesterases hydrolyze chemicals containing such functional groups as a carboxylic
acid ester, amide and thioester. The liver contains the highest carboxylesterase activity and …

Studies examining the mechanisms by which the liver incurs injury and then regenerates
usually focus on factors and pathways directly within the liver, neglecting the signaling derived …

This study was done to determine if a relationship exists between CYP2E1 induction by
ethanol, lipid peroxidation, and liver pathology in experimental alcohol-induced liver disease in …

This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis
induced by diet and farnesoid X receptor (FXR) deficiency in both genders. A control diet (CD…

Dysregulated bile acid (BA) synthesis or reduced farnesoid X receptor (FXR) levels are found
in patients having metabolic diseases, autoimmune hepatitis, and liver cirrhosis or cancer. …

Identification of genetic variation predictive of clearance rate of a wide variety of prescription
drugs could lead to cost-effective personalized medicine. Here we identify regulatory genes …