Oxidative stress has been proposed as an important promoter of the progression of fatty liver
diseases. The current study investigates the potential functions of the Nrf2–Keap1 signaling …

Temporal coordination of hepatic drug-processing gene (DPG) expression facilitates absorption,
biotransformation, and excretion of exogenous and endogenous compounds. To further …

Background Diurnal fluctuation of bile acid (BA) concentrations in the enterohepatic system
of mammals has been known for a long time. Recently, BAs have been recognized as …

Acute fasting causes elevated oxidative stress. The current study investigated the effects of
the nuclear factor erythoid 2-related factor 2 (Nrf2), the sensor of oxidative stress in cells, on …

Sex differences and circadian variation are two major factors that affect the expression of
drug-processing genes. This study aimed to examine sex differences in the circadian variation …

Nrf2, a master regulator of intracellular redox homeostasis, is indicated to participate in fatty
acid metabolism in liver. However, its role in diet-induced obesity remains controversial. In …

The mammalian clock regulates major aspects of energy metabolism, including glucose and
lipid homoeostasis as well as mitochondrial oxidative metabolism. This study is to identify …

Metallothionein (MT) is a small, cysteine-rich, metal-binding protein that plays an important
role in protecting against toxicity of heavy metal and chemicals. This study was aimed to …

Liver is the major organ that eliminates xenobiotics from the body, a process that is accomplished
by a series of drug-processing genes (DPGs). These genes encode transporters on …

The nuclear receptor constitutive androstane receptor (CAR) is a key regulator for drug
metabolism in liver. Human CAR (hCAR) transcripts are subjected to alternative splicing. Some …