[PDF][PDF] Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis

H Hao, L Cao, C Jiang, Y Che, S Zhang, S Takahashi… - Cell metabolism, 2017 - cell.com
Cholestasis is a common complication of sepsis, and the increased plasma levels of bile
acids are predictive of sepsis-associated mortality. However, the exact mechanism by which …

Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function

J Hu, H Huang, Y Che, C Ding, L Zhang, Y Wang… - Journal of …, 2021 - Elsevier
Yuan Che: Formal analysis, Data curation, assisted to perform the experiments and analyze
and interpret data, perform statistical analysis. Chujie Ding: Formal analysis, Data curation, …

[PDF][PDF] Apaf-1 pyroptosome senses mitochondrial permeability transition

W Xu, Y Che, Q Zhang, H Huang, C Ding, Y Wang… - Cell metabolism, 2021 - cell.com
Caspase-4 is an intracellular sensor for cytosolic bacterial lipopolysaccharide (LPS) and
underlies infection-elicited pyroptosis. It is unclear whether and how caspase-4 detects host-…

Palladium‐Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

YY Che, Y Yue, LZ Lin, B Pei, X Deng… - Angewandte Chemie …, 2020 - Wiley Online Library
Herein, we report a highly efficient and practical method for pyridine‐derived heterobiaryl
synthesis through palladium‐catalyzed electrophilic functionalization of easily available …

Kynurenic acid/GPR35 axis restricts NLRP3 inflammasome activation and exacerbates colitis in mice with social stress

X Zheng, M Hu, X Zang, Q Fan, Y Liu, Y Che… - Brain, Behavior, and …, 2019 - Elsevier
Psychological stress is well known to increase colitis susceptibility and promote relapse.
Metabolic changes are commonly observed under psychological stress, but little is known how …

Glycyrrhizin protects against acetaminophen-induced acute liver injury via alleviating tumor necrosis factor α–mediated apoptosis

…, KW Krausz, C Xie, X Cheng, J Zhang, Y Che… - Drug Metabolism and …, 2016 - ASPET
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in
Western countries. Glycyrrhizin (GL), a potent hepatoprotective constituent extracted from the …

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure

W Xu, Q Zhang, C Ding, H Sun, Y Che… - Acta Pharmacologica …, 2021 - nature.com
Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is
involved in various organ dysfunction syndromes. Recent studies have revealed that a …

Improved drug delivery and anti-tumor efficacy of combinatorial liposomal formulation of genistein and plumbagin by targeting Glut1 and Akt3 proteins in mice bearing …

YY Song, Y Yuan, X Shi, YY Che - Colloids and Surfaces B: Biointerfaces, 2020 - Elsevier
Despite the plethora of significant research progress made to develop novel strategies for
the treatment of prostate cancer, this disease remains one of the major global health …

Research on government logistics subsidies for poverty alleviation with non-uniform distribution of consumers

Y Zhou, Y Che - Omega, 2021 - Elsevier
We develop a Hotelling model with an asymmetric triangular distribution of consumer density
to analyze the influence of the agricultural product upstream logistics subsidy (PUS) and …

[HTML][HTML] Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells

Z Pu, Y Che, W Zhang, H Sun… - International …, 2019 - spandidos-publications.com
The main aim of the present study was to investigate the dual roles and mechanism of interleukin
(IL)‑18 in dextran sulfate sodium (DSS)‑induced colitis. Firstly, meta‑analysis was used …