Although AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a central
member of possibly the most frequently activated proliferation and survival pathway in cancer, …

The RB gene product is a nuclear phosphoprotein that undergoes cell cycle-dependent
changes in its phosphorylation status. To test whether RB regulates cell cycle progression, …

THE growth suppression function of the retinoblastoma protein (Rb) is thought to be
mediated by Rb binding to cellular proteins 1 . p48 is one of the major proteins that binds to a …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low
density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, …

Background: Proprotein convertase subtilisin kexin type 9 (PCSK9) is gaining attention as a
key regulator of serum LDL-cholesterol (LDLC). This novel serine protease causes the …

Transmembrane AMPA receptor regulatory proteins (TARPs) and cornichon proteins (CNIH-2/3)
independently modulate AMPA receptor trafficking and gating. However, the potential …

Entry into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which
dephosphorylates and activates the cyclin B-Cdc2 complex. Previous work has shown that …

AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family
that appears to be important in triglyceride biosynthesis in several tissues, but the precise …

Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and
reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how …

Background: During oocyte maturation in Xenopus, progesterone induces entry into meiosis
I, and the M phases of meiosis I and II occur consecutively without an intervening S phase. …