Potential role of CYP2D6 in the central nervous system
J Cheng, Y Zhen, S Miksys, D Beyoğlu, KW Krausz… - Xenobiotica, 2013 - Taylor & Francis
Cytochrome P450 2D6 (CYP2D6) is a pivotal enzyme responsible for a major drug oxidation
polymorphism in human populations. Distribution of CYP2D6 in brain and its role in …
polymorphism in human populations. Distribution of CYP2D6 in brain and its role in …
Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor α expression and activation
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor with manifold
effects on intermediary metabolism. To define a set of urinary biomarkers that could be used to …
effects on intermediary metabolism. To define a set of urinary biomarkers that could be used to …
[HTML][HTML] Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor α and role of the hypothalamic-pituitary-adrenal axis
T Wang, YM Shah, T Matsubara, Y Zhen… - Journal of biological …, 2010 - ASBMB
A previous study identified the peroxisome proliferator-activated receptor α (PPARα) activation
biomarkers 21-steroid carboxylic acids 11β-hydroxy-3,20-dioxopregn-4-en-21-oic acid (…
biomarkers 21-steroid carboxylic acids 11β-hydroxy-3,20-dioxopregn-4-en-21-oic acid (…
3, 4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio
Y Zhen, O Slanař, KW Krausz, C Chen, J Slavík… - Drug metabolism and …, 2006 - ASPET
Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary
debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We …
debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We …
A novel assay of cell rubidium uptake using graphite furnace atomic absorption: application to rats on a magnesium-deficient diet
Y Zhen, KB Franz, SW Graves - The Journal of nutritional biochemistry, 2005 - Elsevier
The [Na,K]ATPase or sodium pump (SP) is a ubiquitous membrane cation transport system.
Because of its potential participation in the pathophysiology of essential hypertension and …
Because of its potential participation in the pathophysiology of essential hypertension and …
[HTML][HTML] A phase I study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer
P Zhang, L Wang, Y Zhen, Z Wang… - Chinese Journal of …, 2024 - ncbi.nlm.nih.gov
Objective Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor
with the target of epidermal growth factor receptor (EGFR)/human epidermal growth factor …
with the target of epidermal growth factor receptor (EGFR)/human epidermal growth factor …
[BOOK][B] Characterization of the interaction of the human sodium pump with naturally occurring and synthetic novel inhibitors
Y Zhen - 2004 - search.proquest.com
The [Na, K]-ATPase or sodium pump (SP) is a ubiquitous membrane cation transport system.
Because of its potential participation in the pathophysiology of essential hypertension and …
Because of its potential participation in the pathophysiology of essential hypertension and …
Standing passenger space on a bus based on passenger satisfaction
HUO Yue-ying, LI Xiao-juan, YAN Zhen-ying… - Journal of …, 2019 - tseit.org.cn
Abstract: Standing passenger space is a key measure that influences passenger satisfaction
during riding on the bus in public transit. Standing passenger space that makes passenger’…
during riding on the bus in public transit. Standing passenger space that makes passenger’…
The R132H mutation in IDH 1 promotes the recruitment of NK cells through CX 3 CL 1/CX 3 CR 1 chemotaxis and is correlated with a better prognosis in gliomas
F Ren, Q Zhao, L Huang, Y Zheng, L Li… - Immunology and cell …, 2019 - Wiley Online Library
Mutations in the isocitrate dehydrogenase ( IDH ) 1 gene, especially the R132H mutation,
have been reported to be associated with a better prognosis in glioma patients. However, the …
have been reported to be associated with a better prognosis in glioma patients. However, the …
Occurrence law of coal seam gas under influence of normal fault zone in coal measures
…, HAN Kai, GAO Zhen, C Yueying - Coal Geology & …, 2022 - cge.researchcommons.org
The coal measure fault zone generated by the superimposition of the polytropic movement
and multiple structure has important effects on the coal seam gas occurrence. The method of …
and multiple structure has important effects on the coal seam gas occurrence. The method of …