Potential role of CYP2D6 in the central nervous system

J Cheng, Y Zhen, S Miksys, D Beyoğlu, KW Krausz… - Xenobiotica, 2013 - Taylor & Francis
Cytochrome P450 2D6 (CYP2D6) is a pivotal enzyme responsible for a major drug oxidation
polymorphism in human populations. Distribution of CYP2D6 in brain and its role in …

Metabolomic and genetic analysis of biomarkers for peroxisome proliferator-activated receptor α expression and activation

Y Zhen, KW Krausz, C Chen, JR Idle… - Molecular …, 2007 - academic.oup.com
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor with manifold
effects on intermediary metabolism. To define a set of urinary biomarkers that could be used to …

[HTML][HTML] Control of steroid 21-oic acid synthesis by peroxisome proliferator-activated receptor α and role of the hypothalamic-pituitary-adrenal axis

T Wang, YM Shah, T Matsubara, Y Zhen… - Journal of biological …, 2010 - ASBMB
A previous study identified the peroxisome proliferator-activated receptor α (PPARα) activation
biomarkers 21-steroid carboxylic acids 11β-hydroxy-3,20-dioxopregn-4-en-21-oic acid (…

3, 4-Dehydrodebrisoquine, a novel debrisoquine metabolite formed from 4-hydroxydebrisoquine that affects the CYP2D6 metabolic ratio

Y Zhen, O Slanař, KW Krausz, C Chen, J Slavík… - Drug metabolism and …, 2006 - ASPET
Considerable unexplained intersubject variability in the debrisoquine metabolic ratio (urinary
debrisoquine/4-hydroxydebrisoquine) exists within individual CYP2D6 genotypes. We …

A novel assay of cell rubidium uptake using graphite furnace atomic absorption: application to rats on a magnesium-deficient diet

Y Zhen, KB Franz, SW Graves - The Journal of nutritional biochemistry, 2005 - Elsevier
The [Na,K]ATPase or sodium pump (SP) is a ubiquitous membrane cation transport system.
Because of its potential participation in the pathophysiology of essential hypertension and …

[HTML][HTML] A phase I study of Hemay022, an irreversible dual EGFR/HER2 tyrosine kinase inhibitor in Chinese patients with HER2-positive advanced breast cancer

P Zhang, L Wang, Y Zhen, Z Wang… - Chinese Journal of …, 2024 - ncbi.nlm.nih.gov
Objective Hemay022 is a novel small-molecule and an irreversible tyrosine kinase inhibitor
with the target of epidermal growth factor receptor (EGFR)/human epidermal growth factor …

[BOOK][B] Characterization of the interaction of the human sodium pump with naturally occurring and synthetic novel inhibitors

Y Zhen - 2004 - search.proquest.com
The [Na, K]-ATPase or sodium pump (SP) is a ubiquitous membrane cation transport system.
Because of its potential participation in the pathophysiology of essential hypertension and …

Standing passenger space on a bus based on passenger satisfaction

HUO Yue-ying, LI Xiao-juan, YAN Zhen-ying… - Journal of …, 2019 - tseit.org.cn
Abstract: Standing passenger space is a key measure that influences passenger satisfaction
during riding on the bus in public transit. Standing passenger space that makes passenger’…

The R132H mutation in IDH 1 promotes the recruitment of NK cells through CX 3 CL 1/CX 3 CR 1 chemotaxis and is correlated with a better prognosis in gliomas

F Ren, Q Zhao, L Huang, Y Zheng, L Li… - Immunology and cell …, 2019 - Wiley Online Library
Mutations in the isocitrate dehydrogenase ( IDH ) 1 gene, especially the R132H mutation,
have been reported to be associated with a better prognosis in glioma patients. However, the …

Occurrence law of coal seam gas under influence of normal fault zone in coal measures

…, HAN Kai, GAO Zhen, C Yueying - Coal Geology & …, 2022 - cge.researchcommons.org
The coal measure fault zone generated by the superimposition of the polytropic movement
and multiple structure has important effects on the coal seam gas occurrence. The method of …