Alendronate is a nitrogen-containing bisphosphonate that is widely used for the treatment of
osteoporosis. In this study, we developed a novel self-dissolving micron-size needle array (…

Bisphosphonates are widely used for the treatment and prevention of bone diseases, including
Paget disease, hypercalcemia of malignancy, and postmenopausal osteoporosis. In this …

Interferon alpha (IFNα) is one of the most famous drugs for the treatment of chronic hepatitis
C and various types of human malignancy. Protein drugs, including IFNα, are generally …

Predicting major clearance pathways of drugs is important in understanding their pharmacokinetic
properties in clinical use, such as drug-drug interactions and genetic polymorphisms, …

Background: Prediction and management of drug safety is a global regulatory issue. Safety-related
regulatory actions (SRRAs) are taken mostly when unexpected adverse drug …

Background Emotional intelligence (EI) refers to a person’s ability to acknowledge the
feelings of oneself and others, and to control those feelings so as to behave in a socially …

Background: The purpose of this study was to develop a scale to assess the clinical judgment
of nurses based on the clinical judgment process. Method: Based on a qualitative analysis …

OBJECTIVES: The launch delay of new drugs has been a major public concern in Japan.
Although it is recognized that the delay results from industrial R&D behaviors and regulatory …

We report two cases of eyebrow granulomas in patients who underwent a permanent eye
makeup procedure. A rash was observed 16 months after the procedure in Case 1, and 10 …

| MATERIALS AND METHODS Chemicals The materials used for this experiment were as
follows: 2-pyridinecarboxylic acid (1), 2-pyridinecarboxylic acid methyl ester (2), 2-…