MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate …
K Kajitani, H Yamaguchi, Y Dan, M Furuichi… - Journal of …, 2006 - Soc Neuroscience
Enhanced oxidative stress has been implicated in the excitotoxicity of the CNS, and 8-oxo-7,8-dihydro-guanine
(8-oxoG), a major type of oxidative damage in nucleic acids, was …
(8-oxoG), a major type of oxidative damage in nucleic acids, was …
Polymorphisms and linkage disequilibrium of the OATP8 (OATP1B3) gene in Japanese subjects
M Tsujimoto, S Hirata, Y Dan, H Ohtani… - Drug metabolism and …, 2006 - jstage.jst.go.jp
OATP8, a member of the organic anion-transporting polypeptide family, is expressed on the
sinusoidal membrane of hepatocytes, and transports endogenous organic anions, such as …
sinusoidal membrane of hepatocytes, and transports endogenous organic anions, such as …
Potentiation of domperidone‐induced catalepsy by a P‐glycoprotein inhibitor, cyclosporin A
K Tsujikawa, Y Dan, K Nogawa, H Sato… - … & drug disposition, 2003 - Wiley Online Library
The distribution of domperidone (DOM), a peripheral dopamine D 2 receptor antagonist, to
the brain is restricted by P‐glycoprotein (P‐gp) at the blood–brain barrier (BBB) and for this …
the brain is restricted by P‐glycoprotein (P‐gp) at the blood–brain barrier (BBB) and for this …
Distribution of domperidone into the rat brain is increased by brain ischaemia or treatment with the P-glycoprotein inhibitor verapamil
Y Dan, H Murakami, N Koyabu… - Journal of pharmacy …, 2002 - academic.oup.com
Domperidone (DOM), a peripheral dopamine D2 receptor antagonist, is a substrate of P-glycoprotein
(P-gp). Therefore, the transport of DOM into the brain may be restricted by P-gp …
(P-gp). Therefore, the transport of DOM into the brain may be restricted by P-gp …
Influence of SLCO1B3 gene polymorphism on the pharmacokinetics of digoxin in terminal renal failure
M Tsujimoto, Y Dan, S Hirata, H Ohtani… - Drug metabolism and …, 2008 - Elsevier
Digoxin (DX) is mainly excreted unchanged in the urine. In patients undergoing hemodialysis
(HD patients), the relative contribution of hepatic elimination is increased. DX is a substrate …
(HD patients), the relative contribution of hepatic elimination is increased. DX is a substrate …
Kinetic analysis of the transport of salicylic acid, a nonsteroidal anti-inflammatory drug, across human placenta
K Shintaku, Y Arima, Y Dan, T Takeda, K Kogushi… - Drug metabolism and …, 2007 - ASPET
The aim of this study was to develop a pharmacokinetic model to describe the transplacental
transfer of drugs, based on the human placental perfusion study. The maternal and fetal …
transfer of drugs, based on the human placental perfusion study. The maternal and fetal …
Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus
Y Dan, Y Ohta, D Tsuchimoto, M Ohno, Y Ide, M Sami… - dna repair, 2008 - Elsevier
A second class II AP endonuclease, APEX2, possesses strong 3′–5′ exonuclease and 3′-phosphodiesterase
activities but only very weak AP-endonuclease activity. APEX2 …
activities but only very weak AP-endonuclease activity. APEX2 …
Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys)
T Honda, Y Dan, N Koyabu, I Ieiri, K Otsubo… - Drug metabolism and …, 2002 - Elsevier
We discovered a novel single nucleotide polymorphism (SNP) at position 325 (G325A) in
exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. …
exon 5 of the multidrug-resistance 1 (MDR1) gene in a study of 37 healthy Japanese subjects. …
A randomized controlled trial of panretinal photocoagulation with and without intravitreal ranibizumab in treatment-naive eyes with non–high-risk proliferative diabetic …
…, Q dong Nguyen, W yukihiko Takahashi - Retina, 2015 - journals.lww.com
Purpose: To compare the efficacy of panretinal photocoagulation (PRP) and intravitreal
ranibizumab injection with PRP alone in patients with treatment-naive bilateral non–high-risk …
ranibizumab injection with PRP alone in patients with treatment-naive bilateral non–high-risk …
Clinical features of polycythemia vera and essential thrombocythemia in Japan: retrospective analysis of a nationwide survey by the Japanese Elderly Leukemia and …
K Dan, T Yamada, Y Kimura, N Usui, S Okamoto… - International journal of …, 2006 - Springer
We conducted the first nationwide survey to clarify the clinical features, treatment methods,
and prognoses for polycythemia vera (PV) and essential thrombocythemia (ET). A 1-page …
and prognoses for polycythemia vera (PV) and essential thrombocythemia (ET). A 1-page …