Approach to the comprehensive analysis of glycoproteins isolated from human serum using a multi-lectin affinity column
Z Yang, WS Hancock - Journal of chromatography A, 2004 - Elsevier
Glycosylation is one the most common post-translational modifications (PTM) and glycoproteins
play fundamental roles in a diversity of biological processes. The development of an …
play fundamental roles in a diversity of biological processes. The development of an …
Recommendations for validation of LC-MS/MS bioanalytical methods for protein biotherapeutics
…, F Garofolo, S Kaur, GA Schultz, K Xu, Z Yang… - The AAPS journal, 2015 - Springer
This paper represents the consensus views of a cross-section of companies and
organizations from the USA and Canada regarding the validation and application of liquid …
organizations from the USA and Canada regarding the validation and application of liquid …
MDR1 haplotypes significantly minimize intracellular uptake and transcellular P‐gp substrate transport in recombinant LLC‐PK1 cells
NN Salama, Z Yang, T Bui, RJY Ho - Journal of pharmaceutical sciences, 2006 - Elsevier
To date, research on the effect of single nucleotide polymorphisms (SNPs) on P‐glycoprotein
(P‐gp) expression and functionality has rendered inconsistent results. This study …
(P‐gp) expression and functionality has rendered inconsistent results. This study …
LC− MS/MS Approach for Quantification of Therapeutic Proteins in Plasma Using a Protein Internal Standard and 2D-Solid-Phase Extraction Cleanup
Z Yang, M Hayes, X Fang, MP Daley… - Analytical …, 2007 - ACS Publications
The bioanalysis of plasma samples generated from in vivo studies of therapeutic proteins is
of increasing interesting in the biopharmaceutical industry. The conventional ELISA …
of increasing interesting in the biopharmaceutical industry. The conventional ELISA …
Multilectin affinity chromatography for characterization of multiple glycoprotein biomarker candidates in serum from breast cancer patients
Z Yang, LE Harris, DE Palmer-Toy… - Clinical …, 2006 - academic.oup.com
Background: Glycoproteins are often associated with cancer and are important in serum
studies, for which glycosylation is a common posttranslational modification. Methods: We used …
studies, for which glycosylation is a common posttranslational modification. Methods: We used …
Monitoring glycosylation pattern changes of glycoproteins using multi-lectin affinity chromatography
Z Yang, WS Hancock - Journal of Chromatography A, 2005 - Elsevier
Previously, we reported that the distribution of glycoproteins into the lectin displacement
fractions of a multi-lectin affinity column was determined by the glycosylation patterns of the …
fractions of a multi-lectin affinity column was determined by the glycosylation patterns of the …
Vulnerability of small-cell lung cancer to apoptosis induced by the combination of BET bromodomain proteins and BCL2 inhibitors
LT Lam, X Lin, EJ Faivre, Z Yang, X Huang… - Molecular cancer …, 2017 - AACR
Ten percent to 15% of all lung cancers are small-cell lung cancer (SCLC). SCLC usually
grows and metastasizes before it is diagnosed and relapses rapidly upon treatment. …
grows and metastasizes before it is diagnosed and relapses rapidly upon treatment. …
Deformable ferrofluid-based millirobot with high motion accuracy and high output force
The magnetically actuated robot has valuable potential in biomedicine, bioengineering, and
biophysics for its capability to precisely manipulate particles or biological tissues. However, …
biophysics for its capability to precisely manipulate particles or biological tissues. However, …
Targeting lineage-specific MITF pathway in human melanoma cell lines by A-485, the selective small-molecule inhibitor of p300/CBP
R Wang, Y He, V Robinson, Z Yang, P Hessler… - Molecular cancer …, 2018 - AACR
Metastatic melanoma is responsible for approximately 80% of deaths from skin cancer.
Microphthalmia-associated transcription factor (MITF) is a melanocyte-specific transcription factor …
Microphthalmia-associated transcription factor (MITF) is a melanocyte-specific transcription factor …
A study of glycoproteins in human serum and plasma reference standards (HUPO) using multilectin affinity chromatography coupled with RPLC‐MS/MS
Z Yang, WS Hancock, TR Chew, L Bonilla - Proteomics, 2005 - Wiley Online Library
The glycoproteome is a major subproteome present in human plasma. In this study, we isolated
and characterized approximately 150 glycoproteins from the human plasma and serum …
and characterized approximately 150 glycoproteins from the human plasma and serum …