Research ArticleMinireview
Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism
Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
Drug Metabolism and Disposition April 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
Andrew J. Annalora
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
Craig B. Marcus
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
Patrick L. Iversen
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon
In this issue
Research ArticleMinireview
Alternative P450 Splicing Redirects Human Drug Metabolism
Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen
Drug Metabolism and Disposition April 1, 2017, 45 (4) 375-389; DOI: https://doi.org/10.1124/dmd.116.073254
Jump to section
- Article
- Abstract
- Introduction
- Meta-Analysis of Alternative Gene Splicing in the Cytochrome P450 Superfamily
- Tissue-Specific Alternative Splicing of Cytochrome P450 Genes: Historical Perspective
- Transformation-Sensitive Alternative Splicing in the Cytochrome P450 Superfamily
- Trans-Splicing of Cytochrome P450 Gene Chimeras
- SNP-Sensitive Alternative Splicing in the Cytochrome P450 Superfamily
- Addressing Nontraditional P450 Function and Trafficking Events
- Shaping an Improved Roadmap toward Precision Medicine
- Acknowledgments
- Authorship Contributions
- Footnotes
- Abbreviations
- References
- Figures & Data
- Info & Metrics
- eLetters
- PDF + SI
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