Abstract
By measurement of concentrations of the drugs in plasma, a study has been made of the effect of partial hepatectomy on the metabolic disposition of mephobarbital and phenobarbital in the rat.
Partial hepatectomy has such a large effect on the rate of disappearance of mephobarbital and on the rate of production of phenobarbital from mephobarbital as to suggest that the liver is the principal, if not the only, site of the demethylation of mephobarbital.
Mephobarbital is not as completely converted to phenobarbital in the rat as in the dog.
Footnotes
- Received August 20, 1952.