Mitochondrial biogenesis and dynamics in the developing and diseased heart
- 1Center for Pharmacogenomics, Washington University in St. Louis, St. Louis, Missouri 63110, USA;
- 2Cardiovascular Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827, USA
- Corresponding author: dkelly{at}sbpdiscovery.org
Abstract
The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.269894.115.
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