Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

May 20, 2020

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Crystalline Sponges as a sensitive and fast method for metabolite identification: Application to gemfibrozil and its phase I and II metabolites
Lara Rosenberger, Carolina von Essen, Anupam Khutia, Clemens Kuehn, Klaus Urbahns, Katrin Georgi, Rolf W Hartmann and Lassina Badolo

Drug Metabolism and Disposition May 20, 2020, dmd.120.091140; DOI: https://doi.org/10.1124/dmd.120.091140

May 11, 2020

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Investigating the role of altered systemic albumin concentration on the disposition of theophylline in adult and pediatric asthma patients by using the physiologically based pharmacokinetic approach
Muhammad Fawad Rasool, Ramsha Khalid, Imran Imran, Abdul Majeed, Hamid Saeed, Fawaz Fayez Alasmari, Mohammed Mufadhe Alanazi and Faleh Alqahtani

Drug Metabolism and Disposition May 11, 2020, dmd.120.090969; DOI: https://doi.org/10.1124/dmd.120.090969
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Nucleoside Reverse Transcriptase Inhibitor (NRTI) Interaction with Human Equilibrative Nucleoside Transporters 1 and 2
Siennah R Miller, Raymond K Hau, Joseph L Jilek, Mark N Morales, Stephen H Wright and Nathan J Cherrington

Drug Metabolism and Disposition May 11, 2020, dmd.120.090720; DOI: https://doi.org/10.1124/dmd.120.090720

May 01, 2020

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Concentration dependency of the unbound partition coefficient Kp_uu and its application to correct for exposure related discrepancies between biochemical and cellular potency of KAT6A inhibitors
Cornelius Trünkle, Christian Lechner, Daniel Korr, Léa Bouché, Naomi Barak, Amaury Fernández-Montalván, Roderich D Süssmuth and Andreas Reichel

Drug Metabolism and Disposition May 1, 2020, dmd.120.090563; DOI: https://doi.org/10.1124/dmd.120.090563
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Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki and Hiroshi Suemizu

Drug Metabolism and Disposition May 1, 2020, dmd.120.091090; DOI: https://doi.org/10.1124/dmd.120.091090
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Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes
Stephan Jahn, Lauren Gay, Claire Weaver, Rolf Renne, Taimour Y Langaee, Peter W Stacpoole and Margaret O. James

Drug Metabolism and Disposition May 1, 2020, dmd.120.090639; DOI: https://doi.org/10.1124/dmd.120.090639

April 29, 2020

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Regional proteomic quantification of clinically relevant non-cytochrome P450 enzymes along the human small intestine
Haeyoung Zhang, Chris Wolford, Abdul Basit, Albert P Li, Peter W Fan, Ryan H Takahashi, S. Cyrus Khojasteh, Bill J Smith, Bernard P Murray, Kenneth Thummel and Bhagwat Prasad

Drug Metabolism and Disposition April 29, 2020, dmd.120.090738; DOI: https://doi.org/10.1124/dmd.120.090738
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Nitric Oxide Mediated Degradation of CYP2A6 via the Ubiquitin-Proteasome Pathway in Human Hepatoma Cells
John Cerrone, Choon-Myung Lee, Tian Mi and Edward T Morgan

Drug Metabolism and Disposition April 29, 2020, dmd.119.089961; DOI: https://doi.org/10.1124/dmd.119.089961
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Enrichment-free high throughput LC-MRM quantification of cytochrome P450 proteins in plated human hepatocytes direct from 96-well plates enables routine protein induction measurements
John Savaryn, Ning Liu, Jun Sun, Junli Ma, David M Stresser and Gary Jenkins

Drug Metabolism and Disposition April 29, 2020, dmd.120.090480; DOI: https://doi.org/10.1124/dmd.120.090480

April 17, 2020

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Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination?
Jasleen K. Sodhi, Hong-Jaan Wang and Leslie Z. Benet

Drug Metabolism and Disposition April 17, 2020, dmd.120.090530; DOI: https://doi.org/10.1124/dmd.120.090530

January 03, 2020

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MRP3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie

Drug Metabolism and Disposition January 3, 2020, dmd.119.089193; DOI: https://doi.org/10.1124/dmd.119.089193

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