Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

October 16, 2019

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Brain distributional kinetics of a novel MDM2 inhibitor SAR405838: Implications for use in brain tumor therapy.
Minjee Kim, Janice K Laramy, Gautham Gampa, Karen E Parrish, Richard C Brundage, Jann N. Sarkaria and William F. Elmquist

Drug Metabolism and Disposition October 16, 2019, dmd.119.088716; DOI: https://doi.org/10.1124/dmd.119.088716

October 08, 2019

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Toxicokinetic interaction between hepatic disposition and pulmonary bioactivation of inhaled naphthalene studied using Cyp2abfgs-null and CYP2A13/2F1-humanized mice with deficient hepatic cytochrome P450 activity
Nataliia Kovalchuk, Qing-Yu Zhang, Jacklyn Kelty, Laura S Van Winkle and Xinxin Ding

Drug Metabolism and Disposition October 8, 2019, dmd.119.088930; DOI: https://doi.org/10.1124/dmd.119.088930

October 03, 2019

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Organic anion transporting polypeptide (OATP) genes are not induced by the pregnane X receptor (PXR) activator rifampin: studies in hepatocytes in vitro and in monkeys in vivo
Congrong Niu, Yujin Wang, Xiaofeng Zhao, Sam Tep, Eisuke Murakami, Raju Subramanian, Bill Smith and Yurong Lai

Drug Metabolism and Disposition October 3, 2019, dmd.119.088922; DOI: https://doi.org/10.1124/dmd.119.088922

October 02, 2019

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The role of L- and D-menthol in the glucuronidation and detoxification of the major lung carcinogen, NNAL
Shannon Kozlovich, Gang Chen, Christy JW Watson, William J Blot and Philip Lazarus

Drug Metabolism and Disposition October 2, 2019, dmd.119.088351; DOI: https://doi.org/10.1124/dmd.119.088351
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An Accurate In Vitro Prediction of Human VDss Based on the ØIE-TOZER Equation and Primary Physicochemical Descriptors. 3. Analysis and Assessment of Predictivity on a Large Dataset.
Giuliano Berellini and Franco Lombardo

Drug Metabolism and Disposition October 2, 2019, dmd.119.088914; DOI: https://doi.org/10.1124/dmd.119.088914
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Ginsenoside Rc is a new selective UGT1A9 inhibitor in human liver microsomes and recombinant human UGT isoforms
Hyunyoung Lee, Jae-Kyung Heo, Ga-Hyun Lee, So-Young Park, Su Nyeoung Jang, Hyun-Ji Kim, Mi Jeong Kwon, Im-Sook Song and Kwang-Hyeon Liu

Drug Metabolism and Disposition October 2, 2019, dmd.119.087965; DOI: https://doi.org/10.1124/dmd.119.087965

September 28, 2019

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Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation
Hong-Jaan Wang and Leslie Z. Benet

Drug Metabolism and Disposition September 28, 2019, dmd.119.088872; DOI: https://doi.org/10.1124/dmd.119.088872

September 24, 2019

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In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly
Christine M Bowman and Leslie Z. Benet

Drug Metabolism and Disposition September 24, 2019, dmd.119.088427; DOI: https://doi.org/10.1124/dmd.119.088427

August 19, 2019

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Enhanced and Persistent Inhibition of Organic Cation Transporter 1 (OCT1) Activity by Preincubation of Cyclosporine A
Erika Panfen, Weiqi Chen, Yueping Zhang, Michael Sinz, Punit Marathe, Jinping Gan and Hong Shen

Drug Metabolism and Disposition August 19, 2019, dmd.119.087197; DOI: https://doi.org/10.1124/dmd.119.087197

July 19, 2019

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Development of a gold nanoparticle-functionalized surface plasmon resonance assay for the sensitive detection of monoclonal antibodies and its application in pharmacokinetics
Haihong Bai, Mei Yuan, Xiaojing Wang, Xinghe Wang and Jinjing Che

Drug Metabolism and Disposition July 19, 2019, dmd.119.086249; DOI: https://doi.org/10.1124/dmd.119.086249

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