Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 10, 2019

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Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans
Matti K Itkonen, Aleksi Tornio, Mikko Neuvonen, Pertti J Neuvonen, Mikko Niemi and Janne T. Backman

Drug Metabolism and Disposition January 10, 2019, dmd.118.084665; DOI: https://doi.org/10.1124/dmd.118.084665

January 08, 2019

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A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes vs. Human Liver Tissue Using Quantitative Targeted Proteomics and Cell-Surface Biotinylation
Vineet Kumar, Laurent Salphati, Cornelis E. C. A. Hop, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Scott Heyward and Jashvant D. Unadkat

Drug Metabolism and Disposition January 8, 2019, dmd.118.084988; DOI: https://doi.org/10.1124/dmd.118.084988
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Effect of Osmolality on the Pharmacokinetic Interaction Between Apple Juice and Atenolol in Rats
Yuta Funai, Yoshiyuki Shirasaka, Marika Ishihara, Miyuki Takemura, Kazuki Ichijo, Hisanao Kishimoto and Katsuhisa Inoue

Drug Metabolism and Disposition January 8, 2019, dmd.118.084483; DOI: https://doi.org/10.1124/dmd.118.084483

January 04, 2019

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Use of segregated hepatocyte scaling factors and cross-species relationship to resolve clearance-dependency in prediction of human hepatic clearance
David Hallifax and James Brian Houston

Drug Metabolism and Disposition January 4, 2019, dmd.118.085191; DOI: https://doi.org/10.1124/dmd.118.085191

January 03, 2019

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Continuum of Host-Gut Microbial Co-metabolism: Host CYP3A4/3A7 Are Responsible for Tertiary Oxidations of Deoxycholate Species
Jian Zhang, Ling-Zhi Gao, Yu-Jie Chen, Ping-Ping Zhu, Shan-Shan Yin, Ming-Ming Su, Yan Ni, Jia Miao, Wen-lin Wu, Hong Chen, Kim L.R. Brouwer, Chang-Xiao Liu, Liang Xu, Wei Jia and Ke Lan

Drug Metabolism and Disposition January 3, 2019, dmd.118.085670; DOI: https://doi.org/10.1124/dmd.118.085670
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The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 protein expression During Cell Differentiation.
Misgana Idris, Neville J Butcher and Rodney F Minchin

Drug Metabolism and Disposition January 3, 2019, dmd.118.085290; DOI: https://doi.org/10.1124/dmd.118.085290

January 02, 2019

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Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-glucuronide and 4-Methylesculetin-7-O-glucuronide
Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu and Lijun Zhu

Drug Metabolism and Disposition January 2, 2019, dmd.118.083493; DOI: https://doi.org/10.1124/dmd.118.083493

December 31, 2018

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Commensal gut bacteria convert the immunosuppressant tacrolimus to less potent metabolites
Yukuang Guo, Camila Manoel Crnkovic, Kyoung-Jae Won, Xiaotong Yang, John Richard Lee, Jimmy Orjala, Hyunwoo Lee and Hyunyoung Jeong

Drug Metabolism and Disposition December 31, 2018, dmd.118.084772; DOI: https://doi.org/10.1124/dmd.118.084772

December 28, 2018

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In Silico Prediction of the Absorption and Disposition of Cefadroxil in Humans using an Intestinal Permeability Method Scaled from Humanized PepT1 Mice
Yongjun Hu and David E Smith

Drug Metabolism and Disposition December 28, 2018, dmd.118.084236; DOI: https://doi.org/10.1124/dmd.118.084236
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Hepatic OATP-mediated clearance in the Beagle dog: assessing in vitro-in vivo relationships and applying cross species empirical scaling factors to improve prediction of human clearance
Norikazu Matsunaga, Ayse Ufuk, Bridget L Morse, David W Bedwell, Jingqi Bao, Michael A Mohutsky, Kathleen M Hillgren, Stephen D Hall, James Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition December 28, 2018, dmd.118.084194; DOI: https://doi.org/10.1124/dmd.118.084194
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Regulation of Hepatic Long Non-coding RNAs by PXR and CAR Agonists in Mouse Liver
Joseph L Dempsey and Julia Yue Cui

Drug Metabolism and Disposition December 28, 2018, dmd.118.085142; DOI: https://doi.org/10.1124/dmd.118.085142

December 21, 2018

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A recombinant humanized anti-cocaine monoclonal antibody alters the urinary clearance of cocaine and its metabolites in rats
Jordan Marckel, Hanna Wetzel, Sihame Amlal, Hassane Amlal and Andrew Norman

Drug Metabolism and Disposition December 21, 2018, dmd.118.083857; DOI: https://doi.org/10.1124/dmd.118.083857

December 20, 2018

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Suppression of hepatic CYP3A4 expression and activity by 3-methylcholanthrene in humanized PXR-CAR-CYP3A4/3A7 mice
Michael Crosby and David S. Riddick

Drug Metabolism and Disposition December 20, 2018, dmd.118.084509; DOI: https://doi.org/10.1124/dmd.118.084509
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Kinetics of Cyclophosphamide Metabolism in Human, Dog, Cat, and Mouse and Relationship to Cytotoxic Activity and Pharmacokinetics
Dominique A Ramirez, Keagan P Collins, Allister E Aradi, Katherine A Conger and Daniel L Gustafson

Drug Metabolism and Disposition December 20, 2018, dmd.118.083766; DOI: https://doi.org/10.1124/dmd.118.083766

December 19, 2018

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Hepatic enzymes relevant to the disposition of (-)-Δ⁹-tetrahydrocannabinol (THC) and its psychoactive metabolite, 11-OH-THC
Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat

Drug Metabolism and Disposition December 19, 2018, dmd.118.085548; DOI: https://doi.org/10.1124/dmd.118.085548
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Gas-phase rearrangement of the O-glucuronide of Vildagliptin forms product ion fragments suggesting wrongly an N-glucuronide
Andreas Fredenhagen, Jurgen Kuhnol, Matthias Kittelmann and Lukas Oberer

Drug Metabolism and Disposition December 19, 2018, dmd.118.085597; DOI: https://doi.org/10.1124/dmd.118.085597
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Physiology of the neonatal gastrointestinal system relevant to the disposition of orally administered medications
April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota and Wendy Halpern

Drug Metabolism and Disposition December 19, 2018, dmd.118.084418; DOI: https://doi.org/10.1124/dmd.118.084418
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Characterization of anacetrapib distribution into the lipid droplet of adipose tissue in mice and human cultured adipocytes
Douglas G. Johns, Lauretta LeVoci, Mihajlo Krsmanovic, Min Lu, Georgy Hartmann, Suoyu Xu, Sheng-Ping Wang, Ying Chen, Thomas Bateman and Robert O. Blaustein

Drug Metabolism and Disposition December 19, 2018, dmd.118.084525; DOI: https://doi.org/10.1124/dmd.118.084525

December 12, 2018

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Drug and chemical glucosidation by control SupersomesTM and membranes from Spodoptera frugiperda (Sf) 9 cells: Implications for the apparent glucuronidation of xenobiotics by UDP-glucuronosyltransferase 1A5
Nuy Chau, Leyla Kaya, Benjamin C Lewis, Peter I Mackenzie and John O Miners

Drug Metabolism and Disposition December 12, 2018, dmd.118.084947; DOI: https://doi.org/10.1124/dmd.118.084947
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Pharmacokinetics, Metabolism, and Excretion of [14C]Esaxerenone, a Novel Mineralocorticoid Receptor Blocker in Humans
Makiko Yamada, Jeanne Mendell, Hideo Takakusa, Takako Shimizu and Osamu Ando

Drug Metabolism and Disposition December 12, 2018, dmd.118.084897; DOI: https://doi.org/10.1124/dmd.118.084897

December 10, 2018

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Hydrolytic Metabolism of Cyanopyrrolidine DPP-4 Inhibitors Mediated by Dipeptidyl Peptidases
Fandi Kong, Xiaoyan Pang, Jihui Zhao, Pan Deng, Mingyue Zheng, Dafang Zhong and Xiaoyan Chen

Drug Metabolism and Disposition December 10, 2018, dmd.118.084640; DOI: https://doi.org/10.1124/dmd.118.084640

December 06, 2018

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Age-Dependency of Blood-Brain Barrier Penetration by cis- and trans-Permethrin in the Rat
Tanzir Mortuza, Gaylen L Edwards, Catherine A White, Vandan Patel, Brian S Cummings and James V Bruckner

Drug Metabolism and Disposition December 6, 2018, dmd.118.084822; DOI: https://doi.org/10.1124/dmd.118.084822

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