Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

July 17, 2017

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Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats
Kevin P Forbes, Evguenia Kouranova, Daniel Tinker, Karen Janowski, Doug Cortner, Aaron McCoy and Xiaoxia Cui

Drug Metabolism and Disposition July 17, 2017, dmd.117.075788; DOI: https://doi.org/10.1124/dmd.117.075788

July 11, 2017

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Prediction of Clinically Relevant Herb-Drug Clearance Interactions Using a Whole Cell Approach: Schisandra sphenanthera case study
Jonathan P Jackson, Kimberly M Freeman, Weslyn W Friley, Ashley G Herman, Christopher B Black, Kenneth R Brouwer and Amy L Roe

Drug Metabolism and Disposition July 11, 2017, dmd.117.075408; DOI: https://doi.org/10.1124/dmd.117.075408
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Evaluation of expression and glycosylation status of UGT1A10 in Supersomes and intestinal epithelial cells with a novel specific UGT1A10 monoclonal antibody
Shingo Oda, Yukiko Kato, Masahiko Hatakeyama, Atsushi Iwamura, Tatsuki Fukami, Toshiyuki Kume, Tsuyoshi Yokoi and Miki Nakajima

Drug Metabolism and Disposition July 11, 2017, dmd.117.075291; DOI: https://doi.org/10.1124/dmd.117.075291
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Heme Modification Contributes to the Mechanism-Based Inactivation of Human Cytochrome P450 2J2 by Two Terminal Acetylenic Compounds
Hsia-lien Lin, Haoming Zhang, Vyvyca J. Walker, Jaime D'Agostino and Paul F. Hollenberg

Drug Metabolism and Disposition July 11, 2017, dmd.117.075846; DOI: https://doi.org/10.1124/dmd.117.075846

July 05, 2017

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The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates
Luc Raymond Albert Rougee, Michael A. Mohutsky, David W. Bedwell, Kenneth J. Ruterbories and Stephen D. Hall

Drug Metabolism and Disposition July 5, 2017, dmd.117.076331; DOI: https://doi.org/10.1124/dmd.117.076331

June 29, 2017

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Inhibitory effects of selected antituberculosis drugs on common human hepatic cytochrome P450 and UDP-glucuronosyltransferase enzymes
Lei Cao, David J. Greenblatt and Awewura Kwara

Drug Metabolism and Disposition June 29, 2017, dmd.117.076034; DOI: https://doi.org/10.1124/dmd.117.076034

June 23, 2017

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on Down-regulation, CYP2C Induction and CYP2B6 Positive Control
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley and Donald Tweedie

Drug Metabolism and Disposition June 23, 2017, dmd.116.074567; DOI: https://doi.org/10.1124/dmd.116.074567
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Identification of flavin-containing monooxygenase 5 (FMO5) as a regulator of glucose homeostasis and a potential sensor of gut bacteria
Flora Scott, Sandra G Gonzalez Malagon, Brett A O'Brien, Diede Fennema, Sunil Veeravalli, Clarissa R Coveney, Ian R Phillips and Elizabeth A. Shephard

Drug Metabolism and Disposition June 23, 2017, dmd.117.076612; DOI: https://doi.org/10.1124/dmd.117.076612
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Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases
Dustyn A Barnette, Bryce Johnson, Dakota L Pouncey, Robert Nshimiyimana, Linda Desrochers, Thomas E Goodwin and Grover Paul Miller

Drug Metabolism and Disposition June 23, 2017, dmd.117.075929; DOI: https://doi.org/10.1124/dmd.117.075929

June 12, 2017

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Age-dependent protein abundance of cytosolic alcohol and aldehyde dehydrogenases in human liver
Deepak Kumar Bhatt, Andrea Gaedigk, Robin E. Pearce, J. Steven Leeder and Bhagwat Prasad

Drug Metabolism and Disposition June 12, 2017, dmd.117.076463; DOI: https://doi.org/10.1124/dmd.117.076463

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