Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 20, 2020

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Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine
Narciso Couto, Zubida Al-Majdoub, Stephanie Gibson, Pamela Davies, Brahim Achour, Matthew D Harwood, Gordon Carlson, Jill Barber, Amin Rostami-Hodjegan and Geoffrey Warhurst

Drug Metabolism and Disposition January 20, 2020, dmd.119.089656; DOI: https://doi.org/10.1124/dmd.119.089656

January 18, 2020

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Carbonyl reductase 1 plays a significant role in converting doxorubicin to cardiotoxic doxorubicinol in mouse liver, but the majority of the doxorubicinol-forming activity remains unidentified
Daniel H Breysse, Ryan M Boone, Cameron M Long, Miranda E Merrill, Christopher M Schaupp, Collin C White, Terrance J Kavanagh, Edward E Schmidt and Gary Frederic Merrill

Drug Metabolism and Disposition January 18, 2020, dmd.119.089326; DOI: https://doi.org/10.1124/dmd.119.089326

January 07, 2020

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Biotransformation Pathways and Metabolite Profiles of Oral [14C]-Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors
Sandeepraj Pusalkar, Xiaofei Zhou, Yuexian Li, Lawrence Cohen, Jun Johnny Yang, Suresh K. Balani, Cindy Xia, Wen Chyi Shyu, Chuang Lu, Karthik Venkatakrishnan and Swapan K. Chowdhury

Drug Metabolism and Disposition January 7, 2020, dmd.119.087338; DOI: https://doi.org/10.1124/dmd.119.087338

January 03, 2020

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MRP3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie

Drug Metabolism and Disposition January 3, 2020, dmd.119.089193; DOI: https://doi.org/10.1124/dmd.119.089193

December 31, 2019

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The Human UGT2B7 Nanodisc
Ian Cook, Ana B. Asenjo, Hernando Sosa and Thomas S. Leyh

Drug Metabolism and Disposition December 31, 2019, dmd.119.089946; DOI: https://doi.org/10.1124/dmd.119.089946

December 30, 2019

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Influence of UGT1A1 and SLCO1B1 Polymorphisms and Efavirenz on Bilirubin Disposition in Healthy Volunteers
Kimberly S. Collins, Ingrid F. Metzger, Brandon T. Gufford, Jessica Lu, Elizabeth B. Medeiros, Victoria M. Pratt, Todd C. Skaar and Zeruesenay Desta

Drug Metabolism and Disposition December 30, 2019, dmd.119.089052; DOI: https://doi.org/10.1124/dmd.119.089052

December 26, 2019

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Induction of Human Intestinal and Hepatic Organic Anion Transporting Polypeptides; Where is the Evidence for its Relevance in Drug-Drug Interactions?
A. David Rodrigues, Yurong Lai, Hong Shen, Manthena V.S. Varma, Andrew Rowland and Stefan Oswald

Drug Metabolism and Disposition December 26, 2019, dmd.119.089615; DOI: https://doi.org/10.1124/dmd.119.089615

December 23, 2019

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Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines
Tormod K Bjånes, Lars Petter Jordheim, Jan Schjøtt, Tina Kamceva, Emeline Cros-Perrial, Anika Langer, Gorka Ruiz de Garibay, Spiros Kotopoulis, Emmet McCormack and Bettina Riedel

Drug Metabolism and Disposition December 23, 2019, dmd.119.089334; DOI: https://doi.org/10.1124/dmd.119.089334
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Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Non-Genetic Regulators
Lucy Her and Hao-Jie Zhu

Drug Metabolism and Disposition December 23, 2019, dmd.119.089680; DOI: https://doi.org/10.1124/dmd.119.089680

December 17, 2019

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UDP-glycosyltransferase 3A (UGT3A) metabolism of polycyclic aromatic hydrocarbons: potential importance in aerodigestive tract tissues
Ana G. Vergara, Christy J.W. Watson, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 17, 2019, dmd.119.089284; DOI: https://doi.org/10.1124/dmd.119.089284

December 15, 2019

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Use of Phenotypically Poor Metabolizer Individual Donor Human Liver Microsomes to Identify Selective Substrates of UGT2B10
Nicolo Milani, Nahong Qiu, Birgit Molitor, Justine Badée, Gabriele Cruciani and Stephen Fowler

Drug Metabolism and Disposition December 15, 2019, dmd.119.089482; DOI: https://doi.org/10.1124/dmd.119.089482

December 13, 2019

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Identification and characterization of a new carboxylesterase 2 isozyme, mfCES2C, in the small intestine of cynomolgus monkeys
Kayoko Ohura, Yoshiyuki Igawa, Maori Tanaka, Kana Matsumoto, Akiko Kasahara, Naoya Wada, Kazuishi Kubota, Yasuhiro Uno and Teruko Imai

Drug Metabolism and Disposition December 13, 2019, dmd.119.089011; DOI: https://doi.org/10.1124/dmd.119.089011

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