Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

June 23, 2017

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on Down-regulation, CYP2C Induction and CYP2B6 Positive Control
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley and Donald Tweedie

Drug Metabolism and Disposition June 23, 2017, dmd.116.074567; DOI: https://doi.org/10.1124/dmd.116.074567
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Identification of flavin-containing monooxygenase 5 (FMO5) as a regulator of glucose homeostasis and a potential sensor of gut bacteria
Flora Scott, Sandra G Gonzalez Malagon, Brett A O'Brien, Diede Fennema, Sunil Veeravalli, Clarissa R Coveney, Ian R Phillips and Elizabeth A. Shephard

Drug Metabolism and Disposition June 23, 2017, dmd.117.076612; DOI: https://doi.org/10.1124/dmd.117.076612
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Stereospecific Metabolism of R- and S-Warfarin by Human Hepatic Cytosolic Reductases
Dustyn A Barnette, Bryce Johnson, Dakota L Pouncey, Robert Nshimiyimana, Linda Desrochers, Thomas E Goodwin and Grover Paul Miller

Drug Metabolism and Disposition June 23, 2017, dmd.117.075929; DOI: https://doi.org/10.1124/dmd.117.075929

June 12, 2017

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Age-dependent protein abundance of cytosolic alcohol and aldehyde dehydrogenases in human liver
Deepak Kumar Bhatt, Andrea Gaedigk, Robin E. Pearce, J. Steven Leeder and Bhagwat Prasad

Drug Metabolism and Disposition June 12, 2017, dmd.117.076463; DOI: https://doi.org/10.1124/dmd.117.076463

June 09, 2017

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Oxetane Substrates of Human Microsomal Epoxide Hydrolase
Francesca Toselli, Marlene Fredenwall, Peder Svensson, Xue-Qing Li, Anders Johansson, Lars Weidolf and Martin A. Hayes

Drug Metabolism and Disposition June 9, 2017, dmd.117.076489; DOI: https://doi.org/10.1124/dmd.117.076489

June 06, 2017

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Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses
Zufei Zhang, Marjorie Z. Imperial, Gabriela I. Patilea-Vrana, Janak Wedagedera, Lu Gaohua and Jashvant D. Unadkat

Drug Metabolism and Disposition June 6, 2017, dmd.117.075192; DOI: https://doi.org/10.1124/dmd.117.075192

June 02, 2017

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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects
Hong Shen, Weiqi Chen, Dieter M Drexler, Sandhya Mandlekar, Vinay K Holenarsipur, Eric E Shields, Robert Langish, Kurex Sidik, Jinping Gan, W Griffith Humphreys, Punit Marathe and Yurong Lai

Drug Metabolism and Disposition June 2, 2017, dmd.117.075531; DOI: https://doi.org/10.1124/dmd.117.075531

June 01, 2017

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PKC/Nedd4-2 Signaling Pathway Regulates the Cell Surface Expression of Drug Transporter hOAT1
Da Xu, Jinghui Zhang, Qiang Zhang, Yunzhou Fan, Chenchang Liu and Guofeng You

Drug Metabolism and Disposition June 1, 2017, dmd.117.075861; DOI: https://doi.org/10.1124/dmd.117.075861

May 31, 2017

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Comparison of 19F-NMR and 14C measurements for the assessment of ADME of BYL719 (Alpelisib) in humans
Alexander D James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner and Gian Camenisch

Drug Metabolism and Disposition May 31, 2017, dmd.117.075424; DOI: https://doi.org/10.1124/dmd.117.075424

May 25, 2017

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Role of CYP2B in Phenobarbital-induced Hepatocyte Proliferation in Mice
Lei Li, Xiaochen Bao, Qing-Yu Zhang, Masahiko Negishi and Xinxin Ding

Drug Metabolism and Disposition May 25, 2017, dmd.117.076406; DOI: https://doi.org/10.1124/dmd.117.076406

May 23, 2017

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Rosuvastatin and Atorvastatin are Ligands of the Human CAR/RXRα Complex
Tadeja Rezen, Mateja Hafner, Sandhya Kortagere, Sean Ekins, Vesna Hodnik and Damjana Rozman

Drug Metabolism and Disposition May 23, 2017, dmd.117.075523; DOI: https://doi.org/10.1124/dmd.117.075523

May 22, 2017

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CRISPR/Cas9 genetic modification of CYP3A5 *3 in HuH-7 human hepatocyte cell line leads to cell lines with increased midazolam and tacrolimus metabolism
Casey R Dorr, Rory P Remmel, Amutha Muthusamy, James Fisher, Branden Moriarity, Kazuto Yasuda, Baolin Wu, Weihua Guan, Erin G. Schuetz, William S Oetting, Pamala A Jacobson and Ajay K Israni

Drug Metabolism and Disposition May 22, 2017, dmd.117.076307; DOI: https://doi.org/10.1124/dmd.117.076307

May 19, 2017

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Direct comparison of the enzymatic characteristics and superoxide production of the four aldehyde oxidase enzymes present in mouse
Gokhan Kucukgoze, Mineko Terao, Enrico Garattini and Silke Leimkuhler

Drug Metabolism and Disposition May 19, 2017, dmd.117.075937; DOI: https://doi.org/10.1124/dmd.117.075937

May 11, 2017

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Regio- and stereo-selective oxidation of a cardiovascular drug metoprolol mediated by cytochrome P450 2D and 3A enzymes in marmoset livers
Shotaro Uehahara, Sakura Ishii, Yasuhiro Uno, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki

Drug Metabolism and Disposition May 11, 2017, dmd.117.075630; DOI: https://doi.org/10.1124/dmd.117.075630

May 09, 2017

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Molecular cloning and characterization of marmoset aldehyde oxidase
Shotaro Uehara, Yasuhiro Uno, Eriko Okamoto, Takashi Inoue, Erika Sasaki and Hiroshi Yamazaki

Drug Metabolism and Disposition May 9, 2017, dmd.117.076042; DOI: https://doi.org/10.1124/dmd.117.076042

January 03, 2017

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Verification of a Maternal-Fetal Physiologically Based Pharmacokinetic Model for Passive Placental Permeability Drugs
Zufei Zhang and Jashvant D. Unadkat

Drug Metabolism and Disposition January 3, 2017, dmd.116.073957; DOI: https://doi.org/10.1124/dmd.116.073957

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