Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

November 15, 2018

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Mechanisms and Clinical Significance of Pharmacokinetic-based Drug-drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2017
Jingjing Yu, Ichiko D. Petrie, Rene H. Levy and Isabelle Ragueneau-Majlessi

Drug Metabolism and Disposition November 15, 2018, dmd.118.084905; DOI: https://doi.org/10.1124/dmd.118.084905
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Bioavailability, Biotransformation, and Excretion of the Covalent BTK Inhibitor Acalabrutinib in Rats, Dogs, and Humans
Terry Podoll, Paul G. Pearson, Jerry Evarts, Tim Ingallinera, Elena Bibikova, Hao Sun, Mark Gohdes, Kristen Cardinal, Mitesh Sanghvi and J. Greg Slatter

Drug Metabolism and Disposition November 15, 2018, dmd.118.084459; DOI: https://doi.org/10.1124/dmd.118.084459
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CHARACTERIZATION OF STEREOSELECTIVE METABOLISM, INHIBITORY EFFECT ON URIC ACID UPTAKE TRANSPORTERS, AND PHARMACOKINETICS OFLESINURAD ATROPISOMERS
Chun Yang, Dongmei Zhou, Zancong Shen, David M Wilson, Matthew Renner, Jeffrey N Miner, Jean-Luc Girardet and Caroline A Lee

Drug Metabolism and Disposition November 15, 2018, dmd.118.080549; DOI: https://doi.org/10.1124/dmd.118.080549

November 12, 2018

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Identification of 19-(S/R)Hydroxyeicosatetraenoic Acid as the First Endogenous Non-Competitive Inhibitor of Cytochrome P450 CYP1B1 with Enantioselective Activity
Sherif M. Shoieb, Ahmed A. El-Sherbeni and Ayman O.S. El-Kadi

Drug Metabolism and Disposition November 12, 2018, dmd.118.084657; DOI: https://doi.org/10.1124/dmd.118.084657
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Prediction of human distribution volumes of compounds in various elimination phases using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in animals
Hidetoshi Shimizu, Kosuke Yoshida, Tomohisa Nakada, Koki Kojima, Akihito Ogasawara, Yoshinobu Nakamaru and Hiroshi Yamazaki

Drug Metabolism and Disposition November 12, 2018, dmd.118.083642; DOI: https://doi.org/10.1124/dmd.118.083642

November 08, 2018

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Berberine Directly Impacts the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation
Yuan Tian, Jingwei Cai, Wei Gui, Robert G. Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha and Andrew D. Patterson

Drug Metabolism and Disposition November 8, 2018, dmd.118.083691; DOI: https://doi.org/10.1124/dmd.118.083691
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Quantitation of lysosomal trapping of basic lipophilic compounds using in vitro assays and in silico predictions based on the determination of the full pH profile of the endo-/lysosomal system in rat hepatocytes
Maximilian V Schmitt, Philip Lienau, Gert Fricker and Andreas Reichel

Drug Metabolism and Disposition November 8, 2018, dmd.118.084541; DOI: https://doi.org/10.1124/dmd.118.084541

November 02, 2018

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Characterization of the in vitro inhibitory potential of the oligonucleotide imetelstat on human cytochrome P450 enzymes with predictions of in vivo drug-drug interactions
Faraz Kazmi, Carlo Sensenhauser and Tony Greway

Drug Metabolism and Disposition November 2, 2018, dmd.118.084103; DOI: https://doi.org/10.1124/dmd.118.084103
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Quantitative Analysis of Ugt1a and Ugt2b mRNA Expression in Rat Liver and Small Intestine: Sex and Strain Differences
Takaya Kutsukake, Yoichi Furukawa, Kyoko Ondo, Saki Gotoh, Tatsuki Fukami and Miki Nakajima

Drug Metabolism and Disposition November 2, 2018, dmd.118.083287; DOI: https://doi.org/10.1124/dmd.118.083287

November 01, 2018

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A Novel Pathogenic UGT1A1 Variant in a Sudanese Child with Type I Crigler-Najjar Syndrome
Walaa Elfar, Erkka Jarvinen, Weizhen Ji, Johanna Mosorin, Annalisa G Sega, Alina C Iuga, Steven J Lobritto, Monica Konstantino, Albert Chan, Moshe Finel and Saquib A Lakhani

Drug Metabolism and Disposition November 1, 2018, dmd.118.084368; DOI: https://doi.org/10.1124/dmd.118.084368

October 26, 2018

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Oral co-administration of fluconazole with tramadol markedly increases plasma and urine concentrations of tramadol and the O-desmethyltramadol metabolite (M1) in healthy dogs
Tania E. Perez Jimenez, Butch Kukanich, Hyun Joo, Katrina L Mealey, Tamara L Grubb, Stephen A Greene and Michael H Court

Drug Metabolism and Disposition October 26, 2018, dmd.118.083444; DOI: https://doi.org/10.1124/dmd.118.083444

October 22, 2018

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Mechanistic in vitro studies indicate that the clinical drug-drug interaction between telithromycin and simvastatin acid is driven by time-dependent inhibition of CYP3A4 with minimal effect on OATP1B1
Robert Elsby, Victoria Hare, Hannah Neal, Samuel Outteridge, Catherine Pearson, Katie Plant, Rachel Upcott Gill, Philip Butler and Robert J Riley

Drug Metabolism and Disposition October 22, 2018, dmd.118.083832; DOI: https://doi.org/10.1124/dmd.118.083832

October 18, 2018

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Evaluation of Carbazeran 4-Oxidation and O6-Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes
Jiarong Xie, Nur Fazilah Saburulla, Shiyan Chen, Siew Ying Wong, Ze Ping Yap, Linghua Harris Zhang and Aik Jiang Lau

Drug Metabolism and Disposition October 18, 2018, dmd.118.082099; DOI: https://doi.org/10.1124/dmd.118.082099

September 19, 2018

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Towards a combinatorial approach for the prediction of immunoglobulin G half-life and clearance
Dennis R. Goulet, Michael J. Watson, Susan H. Tam, Adam Zwolak, Mark L. Chiu, William M. Atkins and Abhinav Nath

Drug Metabolism and Disposition September 19, 2018, dmd.118.081893; DOI: https://doi.org/10.1124/dmd.118.081893

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