Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

August 18, 2017

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Simple evaluation method for CYP3A4 induction from human hepatocytes; The relative factor approach with an induction detection limit concentration based on the E_max model
Shino Kuramoto, Motohiro Kato, Hidetoshi Shindoh, Akihisa Kaneko, Masaki Ishigai and Seiji Miyauchi

Drug Metabolism and Disposition August 18, 2017, dmd.117.076349; DOI: https://doi.org/10.1124/dmd.117.076349
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Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE
Aman P Singh and Dhaval K Shah

Drug Metabolism and Disposition August 18, 2017, dmd.117.076414; DOI: https://doi.org/10.1124/dmd.117.076414

August 08, 2017

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Hepatocyte-specific deletion of EGFR in mice reduces hepatic Abcg2 transport activity measured with [¹¹C]erlotinib and positron emission tomography
Alexander Traxl, Karin Komposch, Elisabeth Glitzner, Thomas Wanek, Severin Mairinger, Oliver Langer and Maria Sibilia

Drug Metabolism and Disposition August 8, 2017, dmd.117.077081; DOI: https://doi.org/10.1124/dmd.117.077081
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CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339
Ryan H Takahashi, Xiaojing Wang, Nathaniel L Segraves, Jing Wang, Jae H Chang, Siamak Cyrus Khojasteh and Shuguang Ma

Drug Metabolism and Disposition August 8, 2017, dmd.117.076786; DOI: https://doi.org/10.1124/dmd.117.076786

August 07, 2017

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An investigation into the prediction of in vivo clearance for a range of Flavin-containing monooxygenase substrates
Barry C Jones, Abhishek Srivastava, Nicola Colclough, Joanne Wilson, Venkatesh Pilla Reddy, Sara Amberntsson and Danxi Li

Drug Metabolism and Disposition August 7, 2017, dmd.117.077396; DOI: https://doi.org/10.1124/dmd.117.077396

August 04, 2017

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Involvement of NF-κB, not PXR, in Inflammation-mediated Regulation of Hepatic Transporters
Walaa A Abualsunun and Micheline Piquette-Miller

Drug Metabolism and Disposition August 4, 2017, dmd.117.076927; DOI: https://doi.org/10.1124/dmd.117.076927

August 02, 2017

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Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase (UGT) Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity
Brahim Achour, Alyssa Dantonio, Mark Niosi, Jonathan J. Novak, John K. Fallon, Jill Barber, Philip C. Smith, Amin Rostami-Hodjegan and Theunis C. Goosen

Drug Metabolism and Disposition August 2, 2017, dmd.117.076703; DOI: https://doi.org/10.1124/dmd.117.076703

July 31, 2017

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Differential Nitric Oxide-Derived Protein Modifications of Flavin-Containing Monooxygenases in Type 1 Allergic Mice
Tadatoshi Tanino, Toru Bando, Akira Komada, Yukie Nojiri, Yuna Okada, Yukari Ueda and Eiichi Sakurai

Drug Metabolism and Disposition July 31, 2017, dmd.117.076570; DOI: https://doi.org/10.1124/dmd.117.076570

July 17, 2017

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Creation and Preliminary Characterization of Pregnane X Receptor and Constitutive Androstane Receptor Knockout Rats
Kevin P Forbes, Evguenia Kouranova, Daniel Tinker, Karen Janowski, Doug Cortner, Aaron McCoy and Xiaoxia Cui

Drug Metabolism and Disposition July 17, 2017, dmd.117.075788; DOI: https://doi.org/10.1124/dmd.117.075788

June 23, 2017

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on Down-regulation, CYP2C Induction and CYP2B6 Positive Control
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Jane R Kenny, Heidi Einolf, Michael Mohutsky, Magalie Pardon, Amy Y Siu, Liangfu Chen, Michael Sinz, Barry Jones, Robert Walsky, Shannon Dallas, Suresh K Balani, George Zhang, David Buckley and Donald Tweedie

Drug Metabolism and Disposition June 23, 2017, dmd.116.074567; DOI: https://doi.org/10.1124/dmd.116.074567

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