Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

September 22, 2017

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RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice
Zidong Donna Fu, Felcy P Selwyn, Julia Yue Cui and Curtis D. Klaassen

Drug Metabolism and Disposition September 22, 2017, dmd.117.077313; DOI: https://doi.org/10.1124/dmd.117.077313
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Species-specific involvement of aldehyde oxidase and xanthine oxidase in the metabolism of the pyrimidine-containing mGlu₅ negative allosteric modulator VU0424238 (auglurant)
Rachel D Crouch, Anna L Blobaum, Andrew S Felts, P. Jeffrey Conn and Craig W Lindsley

Drug Metabolism and Disposition September 22, 2017, dmd.117.077552; DOI: https://doi.org/10.1124/dmd.117.077552

September 21, 2017

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Use of hybrid capillary tube setup on 400MHz NMR for quantitation of crucial low quantity metabolites using aSICCO signal
Ranjeet Tiwari, Deepak Ahire, Hemantha Kumar, Sarmistha Sinha, Siddheshwar Kisan Chauthe, Murali Subramanian, Ramaswamy Iyer, Ramakanth Sarabu and Lakshmi Kant Bajpai

Drug Metabolism and Disposition September 21, 2017, dmd.117.077073; DOI: https://doi.org/10.1124/dmd.117.077073
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The effect of chronic treatment with lurasidone on rat liver cytochrome P450 expression and activity in the chronic mild stress (CMS) model of depression
Marta Kot, Anna Haduch, Mariusz Papp and Władysława Anna Daniel

Drug Metabolism and Disposition September 21, 2017, dmd.117.077826; DOI: https://doi.org/10.1124/dmd.117.077826

September 19, 2017

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Progressive and preferential cellular accumulation of hydrophobic bile acids induced by cholestatic drugs is associated with inhibition of their amidation and sulfation
Ahmad Sharanek, Audrey Burban, Lydie Humbert, Christiane Guguen-Guillouzo, Dominique Rainteau and Andre Guillouzo

Drug Metabolism and Disposition September 19, 2017, dmd.117.077420; DOI: https://doi.org/10.1124/dmd.117.077420
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Recovery of CYP3A Phenotype Following Kidney Transplantation
Kristine Hole, Elisabet Storset, Ane Olastuen, Tore Haslemo, Grete Birkeland Kro, Karsten Midtvedt, Anders Asberg and Espen Molden

Drug Metabolism and Disposition September 19, 2017, dmd.117.078030; DOI: https://doi.org/10.1124/dmd.117.078030

September 15, 2017

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Elucidation of the impact of P-glycoprotein and Breast Cancer Resistance Protein on the brain distribution of catechol-O-methyltransferase inhibitors
Joana Bicker, Ana Fortuna, Gilberto Alves, Patricio Soares-da-Silva and Amilcar Falcao

Drug Metabolism and Disposition September 15, 2017, dmd.117.077883; DOI: https://doi.org/10.1124/dmd.117.077883

September 14, 2017

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Physiologically-based pharmacokinetic model predictions of panobinostat (LBH589) as a victim and perpetrator of drug-drug interactions
Heidi J Einolf, Wen Lin, Christina S Won, Lai Wang, Helen Gu, Dung Yu Chun, Handan He and James B. Mangold

Drug Metabolism and Disposition September 14, 2017, dmd.117.076851; DOI: https://doi.org/10.1124/dmd.117.076851

September 13, 2017

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Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance-Linked ABC transporter ABCG2
Megumi Murakami, Shinobu Ohnuma, Michihiro Fukuda, Eduardo E Chufan, Katsuyoshi Kudoh, Keigo Kanehara, Norihiko Sugisawa, Masaharu Ishida, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V Ambudkar and Michiaki Unno

Drug Metabolism and Disposition September 13, 2017, dmd.117.076000; DOI: https://doi.org/10.1124/dmd.117.076000

September 08, 2017

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Clearance prediction methodology needs fundamental improvement: trends common to rat and human hepatocytes/microsomes and implications for experimental methodology
Francesca Leanne Wood, James Brian Houston and David Hallifax

Drug Metabolism and Disposition September 8, 2017, dmd.117.077040; DOI: https://doi.org/10.1124/dmd.117.077040

September 01, 2017

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Wuzhi tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent for renal transplant recipients who are CYP3A5 expressers: a two-phase prospective study
Jia-li Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang and Min Huang

Drug Metabolism and Disposition September 1, 2017, dmd.117.076737; DOI: https://doi.org/10.1124/dmd.117.076737
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Novel Interactions between Gut Microbiome and Host Drug-processing Genes Modify the Hepatic Metabolism of the Environmental Chemicals PBDEs
Cindy Yanfei Li, Soowan Lee, Sara Cade, Li-Jung Kuo, Irvin R. Schultz, Deepak K. Bhatt, Bhagwat Prasad, Theo K. Bammler and Julia Yue Cui

Drug Metabolism and Disposition September 1, 2017, dmd.117.077024; DOI: https://doi.org/10.1124/dmd.117.077024

August 31, 2017

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Physiologically Based Pharmacokinetic (Pbpk) Model of the Cyp2d6 Probe Atomoxetine: Extrapolation to Special Populations and Drug-Drug Interactions
Weize Huang, Mariko Nakano, Jennifer E Sager, Isabelle Ragueneau-Majlessi and Nina Isoherranen

Drug Metabolism and Disposition August 31, 2017, dmd.117.076455; DOI: https://doi.org/10.1124/dmd.117.076455

August 24, 2017

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A comprehensive functional assessment of carboxylesterase 1 nonsynonymous polymorphisms
Xinwen Wang, Nada Rida, Jian Shi, Audrey Wu, Barry Bleske and Hao-Jie Zhu

Drug Metabolism and Disposition August 24, 2017, dmd.117.077669; DOI: https://doi.org/10.1124/dmd.117.077669

August 23, 2017

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CYP-mediated sulfoximine de-imination of AZD6738
Barry C Jones, Roshini Markandu, Chungang Gu and Graeme Scarfe

Drug Metabolism and Disposition August 23, 2017, dmd.117.077776; DOI: https://doi.org/10.1124/dmd.117.077776

August 18, 2017

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Simple evaluation method for CYP3A4 induction from human hepatocytes; The relative factor approach with an induction detection limit concentration based on the E_max model
Shino Kuramoto, Motohiro Kato, Hidetoshi Shindoh, Akihisa Kaneko, Masaki Ishigai and Seiji Miyauchi

Drug Metabolism and Disposition August 18, 2017, dmd.117.076349; DOI: https://doi.org/10.1124/dmd.117.076349
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Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE
Aman P Singh and Dhaval K Shah

Drug Metabolism and Disposition August 18, 2017, dmd.117.076414; DOI: https://doi.org/10.1124/dmd.117.076414

July 31, 2017

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Differential Nitric Oxide-Derived Protein Modifications of Flavin-Containing Monooxygenases in Type 1 Allergic Mice
Tadatoshi Tanino, Toru Bando, Akira Komada, Yukie Nojiri, Yuna Okada, Yukari Ueda and Eiichi Sakurai

Drug Metabolism and Disposition July 31, 2017, dmd.117.076570; DOI: https://doi.org/10.1124/dmd.117.076570

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