Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

July 18, 2018

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Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
J. Gerry Kenna and Jack Uetrecht

Drug Metabolism and Disposition July 18, 2018, dmd.118.082719; DOI: https://doi.org/10.1124/dmd.118.082719

July 17, 2018

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Metabolism of anethole dithiolethione by rat and human liver microsomes: formation of various products deriving from its O-demethylation and S-oxidation. Involvement of cytochromes P450 and flavin monooxygenases in these pathways.
Martin Dulac, Amor Sassi, Citra Nagarathinan, Marie-Odile Christen, Patrick M Dansette, Daniel Mansuy and Jean-Luc Boucher

Drug Metabolism and Disposition July 17, 2018, dmd.118.082545; DOI: https://doi.org/10.1124/dmd.118.082545

July 13, 2018

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Cryopreserved human intestinal mucosal epithelium: a novel in vitro experimental system for the evaluation of enteric drug metabolism, P450 induction, and enterotoxicity
Albert P. Li, Novera Alam, kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang

Drug Metabolism and Disposition July 13, 2018, dmd.118.082875; DOI: https://doi.org/10.1124/dmd.118.082875

July 12, 2018

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Biotransformation of ilaprazole in human liver microsomes and human: role of CYP3A4 in ilaprazole clearance and drug-drug interaction
Jie Pu, Fen Wang, Wei Tang and Mingshe Zhu

Drug Metabolism and Disposition July 12, 2018, dmd.118.081570; DOI: https://doi.org/10.1124/dmd.118.081570

July 10, 2018

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Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis
Birgit M Wollmann, Silje Watterdal Syversen, Maria Vistnes, Elisabeth Lie, Lise L Mehus and Espen Molden

Drug Metabolism and Disposition July 10, 2018, dmd.118.082065; DOI: https://doi.org/10.1124/dmd.118.082065
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Comparison of Antifungal Azole Interactions with Adult Cytochrome P450 3A4 vs. Neonatal Cytochrome P450 3A7
Malika P. Godamudunage, Anne M. Grech and Emily E Scott

Drug Metabolism and Disposition July 10, 2018, dmd.118.082032; DOI: https://doi.org/10.1124/dmd.118.082032

July 06, 2018

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Differences of the in vivo and in vitro metabolism of imrecoxib in humans: formation of rate-limiting aldehyde intermediate
Xiangyu Hou, Jialan Zhou, Songda Yu, Lei Zhou, Yifan Zhang, Dafang Zhong and Xiaoyan Chen

Drug Metabolism and Disposition July 6, 2018, dmd.118.081182; DOI: https://doi.org/10.1124/dmd.118.081182
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Single Nucleotide Polymorphisms (SNPs) Distant from Xenobiotic Response Elements Can Modulate Aryl Hydrocarbon Receptor Function: SNP-Dependent CYP1A1 Induction
Duan Liu, Sisi Qin, Bamiki Ray, Krishna R Kalari, Liewei Wang and Richard M. Weinshilboum

Drug Metabolism and Disposition July 6, 2018, dmd.118.082164; DOI: https://doi.org/10.1124/dmd.118.082164
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Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening
Michele Fedecostante, Koen Westphal, Michele Buono, Natalia Sanchez Romero, Martijn J Wilmer, Janis Kerkering, Pedro Miguel Baptista, Joost G Hoenderop and Rosalinde Masereeuw

Drug Metabolism and Disposition July 6, 2018, dmd.118.080721; DOI: https://doi.org/10.1124/dmd.118.080721

June 29, 2018

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Glycyrrhizin alleviates non-alcoholic steatohepatitis via modulating bile acids and meta-inflammation
Tingting Yan, Hong Wang, Lijuan Cao, Qiong Wang, Shogo Takahashi, Tomoki Yagai, Guolin Li, Kristopher W Krausz, Guangji Wang, Frank J Gonzalez and Haiping Hao

Drug Metabolism and Disposition June 29, 2018, dmd.118.082008; DOI: https://doi.org/10.1124/dmd.118.082008
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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA in vitro response thresholds, variability, and clinical relevance
Jane R Kenny, Diane Ramsden, David B Buckley, Shannon Dallas, Conrad Fung, Michael Mohutsky, Heidi J Einolf, Liangfu Chen, Joshua G Dekeyser, Maria Fitzgerald, Theunis C Goosen, Y Amy Siu, Robert L Walsky, George Zhang, Donald Tweedie and Niresh Hariparsad

Drug Metabolism and Disposition June 29, 2018, dmd.118.081927; DOI: https://doi.org/10.1124/dmd.118.081927

June 21, 2018

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Content and activities of UGT2B7 in human liver in vitro and predicted in vivo: a bottom-up approach
Chen Xu, Jie Gao, Hai-Feng Zhang, Na Gao, Yuan-Yuan Guo, Yan Fang, Qiang Wen and Hai-Ling Qiao

Drug Metabolism and Disposition June 21, 2018, dmd.118.082024; DOI: https://doi.org/10.1124/dmd.118.082024

June 19, 2018

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Complete substrate inhibition of cytochrome P450 2C8 by AZD9496, an oral selective estrogen receptor degrader
Tashinga E Bapiro, Andy Sykes, Scott Martin, Michael Davies, James WT Yates, Matthias Hoch, Helen E Rollison and Barry Jones

Drug Metabolism and Disposition June 19, 2018, dmd.118.081539; DOI: https://doi.org/10.1124/dmd.118.081539

June 18, 2018

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Decreased Kidney Function is Associated with Enhanced Hepatic Flavin Monooxygenase Activity and Increased Circulating Trimethylamine N-oxide Concentrations in Mice
Cassandra Johnson, Alexander J Prokopienko, Raymond E West, Thomas D Nolin and Jason R Stubbs

Drug Metabolism and Disposition June 18, 2018, dmd.118.081646; DOI: https://doi.org/10.1124/dmd.118.081646
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Disposition of Methamphetamine and Major Metabolites in Mice: Role of Organic Cation Transporter 3 (Oct3) in Tissue Selective Accumulation of para-hydroxymethamphetamine
David J Wagner, Laura M Shireman, Sojung Ahn, Danny D. Shen and Joanne Wang

Drug Metabolism and Disposition June 18, 2018, dmd.118.082131; DOI: https://doi.org/10.1124/dmd.118.082131

June 12, 2018

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An investigation into the prediction of the plasma concentration-time profile and its inter-individual variability for a range of flavin-containing monooxygenase substrates using a mechanistic physiologically based pharmacokinetic modelling approach
Venkatesh Pilla Reddy, Barry C Jones, Nicola Colclough, Abhishek Srivastava, Joanne Wilson and Danxi Li

Drug Metabolism and Disposition June 12, 2018, dmd.118.080648; DOI: https://doi.org/10.1124/dmd.118.080648

June 11, 2018

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Transport Kinetics, Selective Inhibition, and Successful Prediction of In Vivo Inhibition of Rat Hepatic Oatps
Kazuya Ishida, Mohammed Ullah, Beata Toth, Viktoria Juhasz and Jashvant D Unadkat

Drug Metabolism and Disposition June 11, 2018, dmd.118.080770; DOI: https://doi.org/10.1124/dmd.118.080770

May 29, 2018

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Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
Hiroyuki Yamaguchi and Toshiaki Takezawa

Drug Metabolism and Disposition May 29, 2018, dmd.118.080820; DOI: https://doi.org/10.1124/dmd.118.080820

May 18, 2018

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Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki

Drug Metabolism and Disposition May 18, 2018, dmd.118.081216; DOI: https://doi.org/10.1124/dmd.118.081216

May 14, 2018

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The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
Bryan Mackowiak, Jessica Hodge, Sydney Stern and Hongbing Wang

Drug Metabolism and Disposition May 14, 2018, dmd.118.081042; DOI: https://doi.org/10.1124/dmd.118.081042

April 03, 2018

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Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

Drug Metabolism and Disposition April 3, 2018, dmd.118.080374; DOI: https://doi.org/10.1124/dmd.118.080374

January 23, 2018

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A novel in vitro experimental system for the evaluation of drug metabolism: Cofactor-supplemented permeabilized cryopreserved human hepatocytes (MetMax™ Cryopreserved Human Hepatocytes)
Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz

Drug Metabolism and Disposition January 23, 2018, dmd.117.079657; DOI: https://doi.org/10.1124/dmd.117.079657

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