Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

March 18, 2019

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Developmental Expression of the Cytosolic Sulfotransferases in Human Liver
Sarah Dubaisi, Joseph A Caruso, Roger Gaedigk, Carrie A. Vyhlidal, Philip C. Smith, Ronald N. Hines, Thomas A. Kocarek and Melissa Runge-Morris

Drug Metabolism and Disposition March 18, 2019, dmd.119.086363; DOI: https://doi.org/10.1124/dmd.119.086363

March 12, 2019

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Mechanistic Evaluation of the Complex Drug-Drug Interactions of Maraviroc: Contribution of Cytochrome P450 3A, P-Glycoprotein and Organic Anion Transporting Polypeptide 1B1
Emi Kimoto, Manoli Vourvahis, Renato J. Scialis, Heather Eng, A. David Rodrigues and Manthena V. S. Varma

Drug Metabolism and Disposition March 12, 2019, dmd.118.085241; DOI: https://doi.org/10.1124/dmd.118.085241

March 11, 2019

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A novel depurination methodology to assess DNA alkylation of chloro bis-seco-cyclopropylbenzoindoles (CBIs) allowed for comparison of minor groove reactivity
Shuai Wang, Buyun Chen, Peter Dragovich, Thomas Pillow, Leanna Staben, Jun Guo, Dian Su, Chenghong Zhang, Sudheer Bobba, Yong Ma, Jianshuang Wang, Dewakar Sangaraju, BinQing Wei, Gail Lewis Phillips, Cyrus Khojasteh and Donglu Zhang

Drug Metabolism and Disposition March 11, 2019, dmd.118.085209; DOI: https://doi.org/10.1124/dmd.118.085209
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Role of ABCG2 in secretion into milk of the anti-inflammatory flunixin and its main metabolite: in vitro-in vivo correlation in mice and cows
Dafne Garcia-Mateos, Alba Maria Garcia-Lino, Indira Alvarez-Fernandez, Esther Blanco-Paniagua, Alvaro de la Fuente, Ana I Alvarez and Gracia Merino

Drug Metabolism and Disposition March 11, 2019, dmd.118.085506; DOI: https://doi.org/10.1124/dmd.118.085506

March 04, 2019

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Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites
Yuli Qian, Xinwen Wang and John S. Markowitz

Drug Metabolism and Disposition March 4, 2019, dmd.118.086074; DOI: https://doi.org/10.1124/dmd.118.086074

February 28, 2019

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Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody
Jean-Philippe Emond, Adrien Labriet, Sylvie Desjardins, Michele Rouleau, Lyne Villeneuve, Helene Hovington, Herve Brisson, Louis Lacombe, David Simonyan, Patrick Caron, Martine Perigny, Bernard Tetu, John K Fallon, Kathrin Klein, Philip C Smith, Uli Zanger, Chantal Guillemette and Eric Levesque

Drug Metabolism and Disposition February 28, 2019, dmd.119.086330; DOI: https://doi.org/10.1124/dmd.119.086330

February 25, 2019

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Mechanistic Assessment of Extrahepatic Contributions to Glucuronidation of Integrase Strand Transfer Inhibitors
Stephanie N Liu, Jessica Bo Li Lu, Christy JW Watson, Philip Lazarus, Zeruesenay Desta and Brandon T Gufford

Drug Metabolism and Disposition February 25, 2019, dmd.118.085035; DOI: https://doi.org/10.1124/dmd.118.085035

February 20, 2019

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Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes
Ronald de Vries, Frank Jacobs, Geert Mannens, Jan Snoeys, Filip Cuyckens, Caly Chien and Peter Ward

Drug Metabolism and Disposition February 20, 2019, dmd.118.084517; DOI: https://doi.org/10.1124/dmd.118.084517
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The Time-course of Aldehyde Oxidase and the Reason Why it is Nonlinear
Armina Abbasi, Erickson M Paragas, Carolyn A Joswig-Jones, John T Rodgers and Jeffrey P. Jones

Drug Metabolism and Disposition February 20, 2019, dmd.118.085787; DOI: https://doi.org/10.1124/dmd.118.085787
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Oxidative Deamination of Emixustat by Human Vascular Adhesion Protein-1/Semicarbazide-sensitive Amine Oxidase
Michael J Reid, Russell Eyre and Terry Podoll

Drug Metabolism and Disposition February 20, 2019, dmd.118.085811; DOI: https://doi.org/10.1124/dmd.118.085811
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A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes
Keith A. Riccardi, David A. Tess, Jian Lin, Roshan Patel, Sangwoo Ryu, Karen Atkinson, Li Di and Rui Li

Drug Metabolism and Disposition February 20, 2019, dmd.118.085639; DOI: https://doi.org/10.1124/dmd.118.085639

February 14, 2019

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Characterization of fasiglifam-related liver toxicity in dogs
Akifumi Kogame, Yuu Moriya, Ikuo Mori, Liping Pan, Akio Morohashi, Takuya Ebihara, Hideo Fukui, Yoshihiko Tagawa and Leslie Z. Benet

Drug Metabolism and Disposition February 14, 2019, dmd.118.084889; DOI: https://doi.org/10.1124/dmd.118.084889

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