Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

November 26, 2019

You have access
Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-mediated Uptake
Bridget L. Morse, Anil Kolur, Loyd R Hudson, Andrew T. Hogan, Lisa Hong Chen, Ryan M. Brackman, Geri A. Sawada, John K. Fallon, Philip C. Smith and Kathleen M. Hillgren

Drug Metabolism and Disposition November 26, 2019, dmd.119.088781; DOI: https://doi.org/10.1124/dmd.119.088781
You have access
Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes
Yasuo Uchida, Ryohei Goto, Hina Takeuchi, Magdalena Łuczak, Takuya Usui, Masanori Tachikawa and Tetsuya Terasaki

Drug Metabolism and Disposition November 26, 2019, dmd.119.089516; DOI: https://doi.org/10.1124/dmd.119.089516

November 22, 2019

You have access
Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate
Aaron G. Bart, Ryan H. Takahashi, Xiaojing Wang and Emily E. Scott

Drug Metabolism and Disposition November 22, 2019, dmd.119.089607; DOI: https://doi.org/10.1124/dmd.119.089607

November 20, 2019

You have access
Piperine is a Mechanism-based inactivator of CYP3A
Tiantian Cui, Qian Wang, Xiaoxiao Tian, Kehan Zhang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition November 20, 2019, dmd.119.088955; DOI: https://doi.org/10.1124/dmd.119.088955

November 19, 2019

You have access
Mechanistic Modeling of the Hepatic Disposition of Estradiol-17β-Glucuronide in Sandwich-Cultured Human Hepatocytes
Katsuaki Ito, Noora Sjostedt and Kim L. R. Brouwer

Drug Metabolism and Disposition November 19, 2019, dmd.119.088898; DOI: https://doi.org/10.1124/dmd.119.088898

November 14, 2019

You have access
Glucuronidation of Abiraterone and its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and their Potential as Inhibitors of Steroid Glucuronidation.
Joanie Vaillancourt, Veronique Turcotte, Patrick Caron, Lyne Villeneuve, Louis Lacombe, Frederic Pouliot, Eric Levesque and Chantal Guillemette

Drug Metabolism and Disposition November 14, 2019, dmd.119.088229; DOI: https://doi.org/10.1124/dmd.119.088229
You have access
N-Oxygenation of Oxycodone and Retro-reduction of Oxycodone N-Oxide
John R. Cashman, Mark Gohdes, Annelies de Kater and Grant Schoenhard

Drug Metabolism and Disposition November 14, 2019, dmd.119.089300; DOI: https://doi.org/10.1124/dmd.119.089300

November 08, 2019

You have access
Insights into the authentic active ingredients and action sites of oral exogenous glutathione in the treatment of ischemic brain injury based on pharmacokinetic-pharmacodynamic studies
Chong Chen, Qingqing Ding, Boyu Shen, Tengjie Yu, He Wang, Yangfan Xu, Huimin Guo, Kangrui Hu, Lin Xie, Guangji Wang and Yan Liang

Drug Metabolism and Disposition November 8, 2019, dmd.119.089458; DOI: https://doi.org/10.1124/dmd.119.089458
You have access
NRF2-independent regulation of CAR by the pro-oxidants cadmium and isothiocyanate in hUGT1 mice
Miles Paszek and Robert H. Tukey

Drug Metabolism and Disposition November 8, 2019, dmd.119.089508; DOI: https://doi.org/10.1124/dmd.119.089508

November 07, 2019

You have access
Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions
Xinwen Wang, Bing He, Jian Shi, Qian Li and Hao-Jie Zhu

Drug Metabolism and Disposition November 7, 2019, dmd.119.089235; DOI: https://doi.org/10.1124/dmd.119.089235
You have access
Assessment and Confirmation of Species Difference in Nonlinear Pharmacokinetics of Atipamezole with Physiologically Based Pharmacokinetic Modeling
Zheng Li, You Gao, Chunmiao Yang, Yanan Xiang, Wenpeng Zhang, Tianhong Zhang, Ruibin Su, Chuang Lu and Xiaomei Zhuang

Drug Metabolism and Disposition November 7, 2019, dmd.119.089151; DOI: https://doi.org/10.1124/dmd.119.089151
You have access
Changes in Organic Anion Transporting Polypeptide (OATP) Uptake in HEK293 Overexpressing Cells In the Presence and Absence of Human Plasma
Christine M. Bowman, Eugene Chen, Liuxi Chen, Yi-Chen Chen, Xiaorong Liang, Matthew Wright, Yuan Chen and Jialin Mao

Drug Metabolism and Disposition November 7, 2019, dmd.119.088948; DOI: https://doi.org/10.1124/dmd.119.088948

November 04, 2019

You have access
A comparative analysis of cytochrome P450 activities in paired liver and small intestinal samples from patients with obesity
Veronica Krogstad, Alexandra Peric, Ida Robertsen, Marianne K. Kringen, Christine Wegler, Philip Carlo Angeles, Joran Hjelmesaeth, Cecilia Karlsson, Shalini Andersson, Per Artursson, Anders Asberg, Tommy B. Andersson and Hege Christensen

Drug Metabolism and Disposition November 4, 2019, dmd.119.087940; DOI: https://doi.org/10.1124/dmd.119.087940

October 22, 2019

You have access
Numerical Analysis of Time Dependent Inhibition by MDMA
John T. Rodgers and Jeffrey P. Jones

Drug Metabolism and Disposition October 22, 2019, dmd.119.089268; DOI: https://doi.org/10.1124/dmd.119.089268

Main menu

User menu

Search