Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

February 21, 2020

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Coordinated regulation of UGT2B15 expression by long noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG cells
Dianke Yu, Jing Chen, Si Chen, Lin Xu, Leihong Wu, Dongying Li, Jiao Luo, Yuan Jin, Yanjie Zhao, Bridgett Knox, William H. Tolleson, Xubing Wang, Lei Guo, Weida Tong and Baitang Ning

Drug Metabolism and Disposition February 21, 2020, dmd.119.090043; DOI: https://doi.org/10.1124/dmd.119.090043
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Theophylline acetaldehyde as the initial product in Doxophylline metabolism in human liver
Xiaohua Zhao, Hong Ma, Qiusha Pan, Haiyi Wang, Xingkai Qian, Peifang Song, Liwei Zou, Mingqing Mao, Shuyue Xia, Guangbo Ge and Ling Yang

Drug Metabolism and Disposition February 21, 2020, dmd.119.089565; DOI: https://doi.org/10.1124/dmd.119.089565
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Evaluation of Quantitative Relationship Between Target Expression and ADC Exposure Inside Cancer Cells
Sharad Sharma, Zhe Li, David Bussing and Dhaval K. Shah

Drug Metabolism and Disposition February 21, 2020, dmd.119.089276; DOI: https://doi.org/10.1124/dmd.119.089276

February 02, 2020

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Drug interactions for low dose inhaled nemiralisib - a case study integrating modelling, in vitro and clinical investigations
Aarti Patel, Robert Wilson, Andrew W Harrell, Kunal S Taskar, Maxine Taylor, Helen Tracey, Kylie Riddell, Alex Georgiou, Anthony P Cahn, Miriam Marotti and Edith M Hessel

Drug Metabolism and Disposition February 2, 2020, dmd.119.089003; DOI: https://doi.org/10.1124/dmd.119.089003

January 29, 2020

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Critical impact of drug-drug interactions via intestinal CYP3A in the risk assessment of weak perpetrators using physiologically based pharmacokinetic models
Makiko Yamada, Shin-ichi Inoue, Daisuke Sugiyama, Yumi Nishiya, Tomoko Ishizuka, Akiko Watanabe, Kengo Watanabe, Shinji Yamashita and Nobuaki Watanabe

Drug Metabolism and Disposition January 29, 2020, dmd.119.089599; DOI: https://doi.org/10.1124/dmd.119.089599

January 24, 2020

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Alternative Splicing in the Nuclear Receptor Superfamily Redirects Human Metabolic Homeostasis.
Andrew J. Annalora, Craig B. Marcus and Patrick L. Iversen

Drug Metabolism and Disposition January 24, 2020, dmd.119.089102; DOI: https://doi.org/10.1124/dmd.119.089102
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Differential role of LXRα and LXRβ in the regulation of UDP-glucuronosyltransferase 1A1 in humanized UGT1 mice
Eva Hansmann, Elvira Mennillo, Emiko Yoda, Melanie Verreault, Olivier Barbier, Shu-Juan Chen and Robert Howard Tukey

Drug Metabolism and Disposition January 24, 2020, dmd.119.090068; DOI: https://doi.org/10.1124/dmd.119.090068
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Effects of Pregnancy on the Pharmacokinetics of Metformin
Michael Z. Liao, Shannon K. Flood Nichols, Mahmoud Ahmed, Shannon Clark, Gary D. Hankins, Steve Caritis, Raman Venkataramanan, David Haas, Sara K. Quinney, Laura S. Haneline, Alan T. Tita, Tracy Manuck, Joanne Wang, Kenneth E. Thummel, Linda Morris Brown, Zhaoxia Ren, Thomas R Easterling and Mary F. Hebert

Drug Metabolism and Disposition January 24, 2020, dmd.119.088435; DOI: https://doi.org/10.1124/dmd.119.088435
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Metabolism and Disposition of Ataluren following Oral Administration to Mice, Rats, Dogs, and Humans
Ronald Kong, Jiyuan Ma, Seongwoo Hwang, Elizabeth Goodwin, Valerie Northcutt, John Babiak, Neil Almstead and Joseph McIntosh

Drug Metabolism and Disposition January 24, 2020, dmd.119.089391; DOI: https://doi.org/10.1124/dmd.119.089391

January 20, 2020

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Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Inter-correlations in the Human Small Intestine
Narciso Couto, Zubida Al-Majdoub, Stephanie Gibson, Pamela Davies, Brahim Achour, Matthew D Harwood, Gordon Carlson, Jill Barber, Amin Rostami-Hodjegan and Geoffrey Warhurst

Drug Metabolism and Disposition January 20, 2020, dmd.119.089656; DOI: https://doi.org/10.1124/dmd.119.089656

January 03, 2020

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MRP3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie

Drug Metabolism and Disposition January 3, 2020, dmd.119.089193; DOI: https://doi.org/10.1124/dmd.119.089193

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