Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

March 19, 2020

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Species Differences of Bile Acid Redox Metabolism: Tertiary Oxidation of Deoxycholate is Conserved in Preclinical Animals
Qiu-hong Lin, Xian-wen Tan, Wen-xia Wang, Wu-shuang Zeng, Lan-lan Gui, Ming-Ming Su, Chang-xiao Liu, Wei Jia, Liang Xu and Ke Lan

Drug Metabolism and Disposition March 19, 2020, dmd.120.090464; DOI: https://doi.org/10.1124/dmd.120.090464
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Insights into Praziquantel metabolism and potential enantiomeric CYP-mediated drug-drug interaction
Gloria Vendrell-Navarro, Holger Scheible, Floriane Lignet, Howard Burt, Christian Luepfert, Andreas Marx, Nada Abla, Piet Swart and Dominique Perrin

Drug Metabolism and Disposition March 19, 2020, dmd.119.089888; DOI: https://doi.org/10.1124/dmd.119.089888
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Mechanistic Studies of Cytochrome P450 3A4 Time Dependent Inhibition Using Two Cysteine- Targeting Electrophiles
John T Barr, Zhican Wang, Xiaoshan Min, Henry J Wienkers, Brooke M Rock, Dan A Rock and Larry C Wienkers

Drug Metabolism and Disposition March 19, 2020, dmd.119.089813; DOI: https://doi.org/10.1124/dmd.119.089813
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The impact of breast cancer resistant protein (BCRP/ABCG2) on drug transport across Caco-2 cell monolayers
Iichiro Kawahara, Satoyo Nishikawa, Akira Yamamoto, Yusuke Kono and Takuya Fujita

Drug Metabolism and Disposition March 19, 2020, dmd.119.088674; DOI: https://doi.org/10.1124/dmd.119.088674
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Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism
James C. Fuscoe, Vikrant Vijay, Joseph P. Hanig, Tao Han, Lijun Ren, James J. Greenhaw, Richard D. Beger, Lisa M. Pence and Qiang Shi

Drug Metabolism and Disposition March 19, 2020, dmd.119.089367; DOI: https://doi.org/10.1124/dmd.119.089367
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Epigenetic Regulation of MDR1 and BCRP Transporters by HDAC Inhibition
Dahea You, Jason R. Richardson and Lauren M. Aleksunes

Drug Metabolism and Disposition March 19, 2020, dmd.119.089953; DOI: https://doi.org/10.1124/dmd.119.089953

March 10, 2020

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Flavin-Containing Monooxygenase 1 (FMO1) Catalyzes the Production of Taurine from Hypotaurine
Sunil Veeravalli, Ian R. Phillips, Rafael T. Freire, Dorsa Varshavi, Jeremy R. Everett and Elizabeth A. Shephard

Drug Metabolism and Disposition March 10, 2020, dmd.119.089995; DOI: https://doi.org/10.1124/dmd.119.089995

March 09, 2020

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Interaction of the brain-selective sulfotransferase SULT4A1 with other cytosolic sulfotransferases: effects on protein expression and function.
Misgana Idris, Deanne J Mitchell, Richard Gordon, Neelima P Sidharthan, Neville J Butcher and Rodney F Minchin

Drug Metabolism and Disposition March 9, 2020, dmd.119.089714; DOI: https://doi.org/10.1124/dmd.119.089714

March 04, 2020

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Characterization of Anti-Neovascularization Activity and Ocular Pharmacokinetics of PI3K/mTOR Inhibitor GNE-947
Xingrong Liu, Xiaorong Liang, Jennifer LeCouter, Savita Ubhayakar, Jacob Chen, Jay Cheng, Tom Lee, Joe Lubach, Jim Nonomiya, Sheerin Shahidi-Latham, Cristine Quiason, Eric Solon, Matthew Wright, Cornelis E. C. A. Hop and Timothy P Heffron

Drug Metabolism and Disposition March 4, 2020, dmd.119.089763; DOI: https://doi.org/10.1124/dmd.119.089763

February 29, 2020

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Ontogeny and cross species comparison of pathways involved in drug absorption, distribution, metabolism and excretion in neonates (Review): KIDNEY
Ruud Bueters, An Bael, Elke Gasthuys, Connie Chen, Michiel F Schreuder and Kendall S Frazier

Drug Metabolism and Disposition February 29, 2020, dmd.119.089755; DOI: https://doi.org/10.1124/dmd.119.089755
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Alteration in the plasma concentrations of endogenous OATP1B-biomarkers in non-small cell lung cancer patients treated with paclitaxel
Daiki Mori, HIROO ISHIDA, Tadahaya Mizuno, Sojiro Kusumoto, Yusuke Kondo, Saki Izumi, Genki Nakata, Yoshitane Nozaki, Kazuya Maeda, Yasutsuna Sasaki, Ken-ichi Fujita and Hiroyuki Kusuhara

Drug Metabolism and Disposition February 29, 2020, dmd.119.089474; DOI: https://doi.org/10.1124/dmd.119.089474
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Role of OATP2B1 in drug absorption and drug-drug interactions
Mingqing Chen, Shuiying Hu, Yang Li, Alice A Gibson, Qiang Fu, Sharyn D Baker and Alex Sparreboom

Drug Metabolism and Disposition February 29, 2020, dmd.119.090316; DOI: https://doi.org/10.1124/dmd.119.090316
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Circadian clock-controlled drug metabolism: Implications for chronotherapeutics
Danyi Lu, Mengjing Zhao, Min Chen and Baojian Wu

Drug Metabolism and Disposition February 29, 2020, dmd.120.090472; DOI: https://doi.org/10.1124/dmd.120.090472

February 24, 2020

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Acetaminophen-induced Liver Injury Alters Expression and Activities of Cytochrome P450 Enzymes in an Age-dependent Manner in Mouse Liver
Yifan Bao, Pei Wang, Xueyan Shao, Junjie Zhu, Jingcheng Xiao, Jian Shi, Lirong Zhang, Hao-Jie Zhu, Xiaochao Ma, Jose E. Manautou and Xiao-bo Zhong

Drug Metabolism and Disposition February 24, 2020, dmd.119.089557; DOI: https://doi.org/10.1124/dmd.119.089557

February 21, 2020

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Theophylline acetaldehyde as the initial product in Doxophylline metabolism in human liver
Xiaohua Zhao, Hong Ma, Qiusha Pan, Haiyi Wang, Xingkai Qian, Peifang Song, Liwei Zou, Mingqing Mao, Shuyue Xia, Guangbo Ge and Ling Yang

Drug Metabolism and Disposition February 21, 2020, dmd.119.089565; DOI: https://doi.org/10.1124/dmd.119.089565
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Evaluation of Quantitative Relationship Between Target Expression and ADC Exposure Inside Cancer Cells
Sharad Sharma, Zhe Li, David Bussing and Dhaval K. Shah

Drug Metabolism and Disposition February 21, 2020, dmd.119.089276; DOI: https://doi.org/10.1124/dmd.119.089276

January 03, 2020

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MRP3 Is Responsible for the Efflux Transport of Curcumin Glucuronide from Hepatocytes to the Blood
Yu-Meng Jia, Ting Zhu, Huan Zhou, Jin-Zi Ji, Ting Tai and Hong-Guang Xie

Drug Metabolism and Disposition January 3, 2020, dmd.119.089193; DOI: https://doi.org/10.1124/dmd.119.089193

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