Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

September 12, 2018

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Metabolism of c-Met kinase inhibitors containing quinoline by aldehyde oxidase, electron donating and steric hindrance effect
Jiang Wei Zhang, Wen Xiao, Zhen Ting Gao, Zheng Tian Yu and Ji Yue (Jeff) Zhang

Drug Metabolism and Disposition September 12, 2018, dmd.118.081919; DOI: https://doi.org/10.1124/dmd.118.081919

September 07, 2018

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6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577) is a Highly Selective Substrate for Glucuronidation by Uridine Diphosphoglucuronosyl Transferase (UGT) 1A1, Relative to b-Estradiol
Kimberly Lapham, Jian Lin, Jonathan Novak, Christine Orozco, Mark Niosi, Li Di, Theunis C Goosen, Sangwoo Ryu, Keith Riccardi, Heather Eng, Kimberly O. Cameron and Amit S. Kalgutkar

Drug Metabolism and Disposition September 7, 2018, dmd.118.083709; DOI: https://doi.org/10.1124/dmd.118.083709

September 04, 2018

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Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro
Michael Gerisch, Roland Heinig, Anna Engelen, Dieter Lang, Peter Kolkhof, Martin Radtke, Johannes Platzek, Kai Lovis, Gabriele Rohde and Thomas Schwarz

Drug Metabolism and Disposition September 4, 2018, dmd.118.083337; DOI: https://doi.org/10.1124/dmd.118.083337

August 31, 2018

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Human Pluripotent Stem Cell Derived Kidney Model for Nephrotoxicity Studies
Piyush Bajaj, A. David Rodrigues, Claire M Steppan, Sandra J Engle, Sumathy Mathialagan and Thomas Schroeter

Drug Metabolism and Disposition August 31, 2018, dmd.118.082727; DOI: https://doi.org/10.1124/dmd.118.082727
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PORCINE PREDICTION OF PHARMACOKINETIC PARAMETERS IN PEOPLE: A PIG IN A POKE?
Huadong Tang and Michael Mayersohn

Drug Metabolism and Disposition August 31, 2018, dmd.118.083311; DOI: https://doi.org/10.1124/dmd.118.083311

August 30, 2018

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Relationship between in vivo CYP3A4 activity, CYP3A5 genotype and systemic tacrolimus metabolite/parent drug ratio in renal transplant recipients and healthy volunteers.
Thomas Vanhove, Hylke de Jonge, Henriette de Loor, Marlies Oorts, Jan de Hoon, Anton Pohanka, Pieter Annaert and Dirk RJ Kuypers

Drug Metabolism and Disposition August 30, 2018, dmd.118.081935; DOI: https://doi.org/10.1124/dmd.118.081935
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Gene-by-Environment Interaction of Bcrp-/- and MCD Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
Erica L Toth, Hui Li, Anika L Dzierlenga, John D Clarke, Anna Vildhede, Michael Goedken and Nathan J Cherrington

Drug Metabolism and Disposition August 30, 2018, dmd.118.082081; DOI: https://doi.org/10.1124/dmd.118.082081

August 29, 2018

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Effect of celecoxib on differentiation of human induced pluripotent stem cells into hepatocytes involves STAT5 activation
Hiroki Okumura, Anna Nakanishi, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

Drug Metabolism and Disposition August 29, 2018, dmd.118.082982; DOI: https://doi.org/10.1124/dmd.118.082982
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An ex vivo fermentation screening platform to study drug metabolism by human gut microbiota
Evita van de Steeg, Frank H.J. Schuren, R. Scott Obach, Claire van Woudenbergh, Gregory S. Walker, Margreet Heerikhuisen, Irene H.G. Nooijen and Wouter H.J. Vaes

Drug Metabolism and Disposition August 29, 2018, dmd.118.081026; DOI: https://doi.org/10.1124/dmd.118.081026

August 28, 2018

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Evaluation of Organic Anion Transporter 1A2-knockin Mice as a Model of Human Blood-Brain Barrier
Yamato Sano, Tadahaya Mizuno, Tatsuki Mochizuki, Yasuno Uchida, Mina Umetsu, Tetsuya Terasaki and Hiroyuki Kusuhara

Drug Metabolism and Disposition August 28, 2018, dmd.118.081877; DOI: https://doi.org/10.1124/dmd.118.081877
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Health-relevant phenotypes in the offspring of mice given CAR activators prior to pregnancy
Karin Dietrich, Jan Baumgart, Leonid Eshkind, Lea Reuter, Ute Godtel-Armbrust, Elke Butt, Michael Musheev, Federico Marini, Piyush More, Tanja Grosser, Christof Niehrs, Leszek Wojnowski and Marianne Mathas

Drug Metabolism and Disposition August 28, 2018, dmd.118.082925; DOI: https://doi.org/10.1124/dmd.118.082925
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Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor Gamma
Jiangming Deng, Lianxia Guo and Baojian Wu

Drug Metabolism and Disposition August 28, 2018, dmd.118.083071; DOI: https://doi.org/10.1124/dmd.118.083071

August 22, 2018

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Perspective on the application of microphysiological systems to drug transporter studies
Pedro Caetano-Pinto and Simone H Stahl

Drug Metabolism and Disposition August 22, 2018, dmd.118.082750; DOI: https://doi.org/10.1124/dmd.118.082750
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Advances in Engineered Human Liver Platforms for Drug Metabolism Studies
Gregory H Underhill and Salman R Khetani

Drug Metabolism and Disposition August 22, 2018, dmd.118.083295; DOI: https://doi.org/10.1124/dmd.118.083295
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Assessment of the Biotransformation of Low Turnover Drugs in the HμREL Human Hepatocyte Coculture Model
Richard D. Burton, Todd Hieronymus, Taysir Chamem, David Heim, Shelby Anderson, Xiaochun Zhu and J. Matthew Hutzler

Drug Metabolism and Disposition August 22, 2018, dmd.118.082867; DOI: https://doi.org/10.1124/dmd.118.082867
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A Commentary: Finding Tmax and Cmax in Multi-Compartmental Models
Yi Rang Han, Ping I. Lee and K. Sandy Pang

Drug Metabolism and Disposition August 22, 2018, dmd.118.082636; DOI: https://doi.org/10.1124/dmd.118.082636
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Application of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells for Studies of Prodrug Hydrolysis and Drug Absorption in the Small Intestine
Takanori Akazawa, Shinpei Yoshida, Shuichi Ohnishi, Takushi Kanazu, Makoto Kawai and Koji Takahashi

Drug Metabolism and Disposition August 22, 2018, dmd.118.083246; DOI: https://doi.org/10.1124/dmd.118.083246
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Accurate estimation of in vivo inhibition constants of inhibitors and fraction metabolized of substrates with physiologically-based pharmacokinetic drug-drug interaction models incorporating parent drugs and metabolites of substrates with cluster Newton method
Kenta Yoshida, Kazuya Maeda, Akihiko Konagaya and Hiroyuki Kusuhara

Drug Metabolism and Disposition August 22, 2018, dmd.118.081828; DOI: https://doi.org/10.1124/dmd.118.081828

August 20, 2018

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CRISPR-Cas9 - a new addition to the drug metabolism and disposition tool box
Maria Karlgren, Ivailo Simoff, Markus Keiser, Stefan Oswald and Per Artursson

Drug Metabolism and Disposition August 20, 2018, dmd.118.082842; DOI: https://doi.org/10.1124/dmd.118.082842
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Physiologically relevant, humanized intestinal systems to study metabolism and transport of small molecule therapeutics: Mini-review
Aarti Sawant-Basak, A. David Rodrigues, Matthew Lech, Regis Doyonnas, Marion Kasaian, Bhagwat Prasad and Nikolaos Tsamandouras

Drug Metabolism and Disposition August 20, 2018, dmd.118.082784; DOI: https://doi.org/10.1124/dmd.118.082784

August 16, 2018

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TREND ANALYSIS OF A DATABASE OF INTRAVENOUS PHARMACOKINETIC PARAMETERS IN HUMANS FOR 1352 DRUG COMPOUNDS
Franco Lombardo, Giuliano Berellini and R. Scott Obach

Drug Metabolism and Disposition August 16, 2018, dmd.118.082966; DOI: https://doi.org/10.1124/dmd.118.082966
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When does the rate-determining step in the hepatic clearance of a drug switch from sinusoidal uptake to all hepatobiliary clearances? Implications for predicting drug-drug interactions
Gabriela I Patilea-Vrana and Jashvant Unadkat

Drug Metabolism and Disposition August 16, 2018, dmd.118.081307; DOI: https://doi.org/10.1124/dmd.118.081307
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Mouse hepatomas with Ha-ras and B-raf mutations differ in mitogen-activated protein kinase signaling and response to constitutive androstane receptor activation
Albert Braeuning, Ferdinand Kollotzek, Eva Zeller, Thomas Knorpp, Markus F. Templin and Michael Schwarz

Drug Metabolism and Disposition August 16, 2018, dmd.118.083014; DOI: https://doi.org/10.1124/dmd.118.083014
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Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice
Faleh Alqahtani, Ekram Ahmed Chowdhury, Raktima Bhattacharya, Behnam Noorani, Reza Mehvar and Ulrich Bickel

Drug Metabolism and Disposition August 16, 2018, dmd.118.082909; DOI: https://doi.org/10.1124/dmd.118.082909
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Retinal Cholesterol Content is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol
Natalia Mast, Ilya R. Bederman and Irina A. Pikuleva

Drug Metabolism and Disposition August 16, 2018, dmd.118.083345; DOI: https://doi.org/10.1124/dmd.118.083345
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Microfluidic cell culture platforms to capture hepatic physiology and complex cellular interactions
Shyam Sundhar Bale and Jeffrey T Borenstein

Drug Metabolism and Disposition August 16, 2018, dmd.118.083055; DOI: https://doi.org/10.1124/dmd.118.083055

August 15, 2018

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Pheophorbide A: Fluorescent Bcrp substrate to measure oral drug-drug interactions in real time in vivo
Kazuto Yasuda, Samit Ganguly and Erin G Schuetz

Drug Metabolism and Disposition August 15, 2018, dmd.118.083584; DOI: https://doi.org/10.1124/dmd.118.083584
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Models and approaches describing metabolism, transport, and toxicity of drugs administered by the ocular route
Jennifer L Dumouchel, Nagendra Chemuturi, Mark N Milton, Gian Camenisch, James E Chastain, Markus Walles, Vito Sasseville, Mithat Gunduz, Ganesh Iyer and Upendra Argikar

Drug Metabolism and Disposition August 15, 2018, dmd.118.082974; DOI: https://doi.org/10.1124/dmd.118.082974
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How to determine the role of the microbiome in drug disposition
Jordan E Bisanz, Peter Spanogiannopoulos, Lindsey M Pieper, Annamarie E Bustion and Peter J Turnbaugh

Drug Metabolism and Disposition August 15, 2018, dmd.118.083402; DOI: https://doi.org/10.1124/dmd.118.083402

August 10, 2018

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Humanized UGT1 mice, regulation of UGT1A1,and the role of the intestinal tract in neonatal hyperbilirubinemia and breast milk induced jaundice
Shujuan Chen and Robert H Tukey

Drug Metabolism and Disposition August 10, 2018, dmd.118.083212; DOI: https://doi.org/10.1124/dmd.118.083212
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Equilibrative nucleoside transporter 1 (ENT1, SLC29A1) facilitates transfer of the antiretroviral drug abacavir across the placenta
Lukas Cerveny, Zuzana Ptackova, Martina Ceckova, Rona Karahoda, Sara Karbanova, Lucie Jiraskova, Susan L Greenwood, Jocelyn D Glazier and Frantisek Staud

Drug Metabolism and Disposition August 10, 2018, dmd.118.083329; DOI: https://doi.org/10.1124/dmd.118.083329

August 09, 2018

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CYP-humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis Pankowicz, Qing-Yu Zhang and Xinxin Ding

Drug Metabolism and Disposition August 9, 2018, dmd.118.083303; DOI: https://doi.org/10.1124/dmd.118.083303

August 03, 2018

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Emerging Kidney Models to Investigate Metabolism, Transport and Toxicity of Drugs and Xenobiotics
Piyush Bajaj, Swapan K Chowdhury, Robert Yucha, Edward J Kelly and Guangquing Xiao

Drug Metabolism and Disposition August 3, 2018, dmd.118.082958; DOI: https://doi.org/10.1124/dmd.118.082958

July 25, 2018

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Mouse Population-Based Approaches to Investigate Adverse Drug Reactions
Merrie Mosedale

Drug Metabolism and Disposition July 25, 2018, dmd.118.082834; DOI: https://doi.org/10.1124/dmd.118.082834

July 18, 2018

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Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?
J. Gerry Kenna and Jack Uetrecht

Drug Metabolism and Disposition July 18, 2018, dmd.118.082719; DOI: https://doi.org/10.1124/dmd.118.082719

July 13, 2018

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Cryopreserved human intestinal mucosal epithelium: a novel in vitro experimental system for the evaluation of enteric drug metabolism, P450 induction, and enterotoxicity
Albert P. Li, Novera Alam, kirsten Amaral, Ming-Chih David Ho, Carol Loretz, Walter Mitchell and Qian Yang

Drug Metabolism and Disposition July 13, 2018, dmd.118.082875; DOI: https://doi.org/10.1124/dmd.118.082875

May 29, 2018

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Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
Hiroyuki Yamaguchi and Toshiaki Takezawa

Drug Metabolism and Disposition May 29, 2018, dmd.118.080820; DOI: https://doi.org/10.1124/dmd.118.080820

May 18, 2018

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Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans
Yuki Yamasaki, Kaoru Kobayashi, Fuka Okuya, Naoyo Kajitani, Kanako Kazuki, Satoshi Abe, Shoko Takehara, Shingo Ito, Seiryo Ogata, Tatsuki Uemura, Sumio Ohtsuki, Genki Minegishi, Hidetaka Akita, Kan Chiba, Mitsuo Oshimura and Yasuhiro Kazuki

Drug Metabolism and Disposition May 18, 2018, dmd.118.081216; DOI: https://doi.org/10.1124/dmd.118.081216

April 03, 2018

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Generation of Intestinal Organoids Suitable for Pharmacokinetic Studies from Human Induced Pluripotent Stem Cells
Daichi Onozato, Misaki Yamashita, Anna Nakanishi, Takumi Akagawa, Yuriko Kida, Isamu Ogawa, Tadahiro Hashita, Takahiro Iwao and Tamihide Matsunaga

Drug Metabolism and Disposition April 3, 2018, dmd.118.080374; DOI: https://doi.org/10.1124/dmd.118.080374

January 23, 2018

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A novel in vitro experimental system for the evaluation of drug metabolism: Cofactor-supplemented permeabilized cryopreserved human hepatocytes (MetMax™ Cryopreserved Human Hepatocytes)
Albert P. Li, Ming-Chih David Ho, Kirsten Amaral and Carol Loretz

Drug Metabolism and Disposition January 23, 2018, dmd.117.079657; DOI: https://doi.org/10.1124/dmd.117.079657

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