Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

June 14, 2019

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The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats
Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi and Leslie Z. Benet

Drug Metabolism and Disposition June 14, 2019, dmd.119.087148; DOI: https://doi.org/10.1124/dmd.119.087148
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Structure guided in-vitro to in-vivo pharmacokinetic optimization of propargyl-linked antifolates
Michael N Lombardo, Narendran G-Dayanandan, Santosh Keshipeddy, Wangda Zhou, Debjani Si, Stephanie M Reeve, Jeremy Alverson, Patrick Barney, Larissa Walker, John Hoody, Nigel Priestley, R. Scott Obach and Dennis L Wright

Drug Metabolism and Disposition June 14, 2019, dmd.119.086504; DOI: https://doi.org/10.1124/dmd.119.086504

June 12, 2019

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PBDEs and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice
David K Scoville, Cindy Yanfei Li, Dongfang Wang, Joseph L Dempsey, Daniel Raftery, Sridhar Mani, Haiwei Gu and Julia Yue Cui

Drug Metabolism and Disposition June 12, 2019, dmd.119.086538; DOI: https://doi.org/10.1124/dmd.119.086538

June 10, 2019

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Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach
Sravani Adusumalli, Rohitash Jamwal, R. Scott Obach, Tim F Ryder, Lorenzo Leggio and Fatemeh Akhlaghi

Drug Metabolism and Disposition June 10, 2019, dmd.119.087015; DOI: https://doi.org/10.1124/dmd.119.087015

June 05, 2019

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Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways
Maciej J Zamek-Gliszczynski, Xuexiang Zhang, Jennypher Mudunuru, Yewei Du, Jian-Lu Chen, Kunal S Taskar, Jane Huang, Yong Huang and Elizabeth H Romach

Drug Metabolism and Disposition June 5, 2019, dmd.119.087635; DOI: https://doi.org/10.1124/dmd.119.087635

June 03, 2019

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Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease
Jacqueline Bezencon, James J Beaudoin, Katsuaki Ito, Dong Fu, Sharin E Roth, William J Brock and Kim LR Brouwer

Drug Metabolism and Disposition June 3, 2019, dmd.119.086785; DOI: https://doi.org/10.1124/dmd.119.086785

May 30, 2019

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Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism
Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yi lin Li, Hao Lin, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition May 30, 2019, dmd.119.086892; DOI: https://doi.org/10.1124/dmd.119.086892
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Defining the contribution of CYP1A1 and CYP1A2 to drug metabolism using humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 KO mice
Yury Kapelyukh, Colin James Henderson, Nico Scheer, Anja Rode and Charles Roland Wolf

Drug Metabolism and Disposition May 30, 2019, dmd.119.087718; DOI: https://doi.org/10.1124/dmd.119.087718

May 23, 2019

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Kidney cortical transporter expression across species using quantitative proteomics
Abdul Basit, Zaher Radi, Vishal S. Vaidya, Matthew Karasu and Bhagwat Prasad

Drug Metabolism and Disposition May 23, 2019, dmd.119.086579; DOI: https://doi.org/10.1124/dmd.119.086579
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Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1
Samantha Medwid, Mandy M.J. Li, Michael J. Knauer, Kathleen Lin, Sara E. Mansell, Crystal L. Schmerk, Catherine Zhu, Katelyn E. Griffin, Mohamed D. Yousif, George K. Dresser, Ute I. Schwarz, Richard B. Kim and Rommel G. Tirona

Drug Metabolism and Disposition May 23, 2019, dmd.119.087619; DOI: https://doi.org/10.1124/dmd.119.087619

May 22, 2019

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Activation of PXR-Cytochrome P450s axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes in vivo
Feng L. Wang, Hui H. Wang, Yi Fan Wu, Lei Wang, Ling Zhang, Xi Ye, Dai Y. Peng and Wei D. Chen

Drug Metabolism and Disposition May 22, 2019, dmd.119.086769; DOI: https://doi.org/10.1124/dmd.119.086769

May 21, 2019

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Plasma protein binding as an optimisable parameter for acidic drugs
Philip Gardiner, Rhona J Cox and Ken Grime

Drug Metabolism and Disposition May 21, 2019, dmd.119.087163; DOI: https://doi.org/10.1124/dmd.119.087163

May 17, 2019

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Ontogeny of Hepatic Sulfotransferases (SULTs) and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism
Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J. Steven Leeder, Michael B. Bolger, Saranjit Singh and Bhagwat Prasad

Drug Metabolism and Disposition May 17, 2019, dmd.119.086462; DOI: https://doi.org/10.1124/dmd.119.086462

May 16, 2019

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Plasma and liver protein binding of GalNAc conjugated siRNA
Sara C Humphreys, Mai B Thayer, Julie M Lade, Bin Wu, Kelvin Sham, Babak Basiri, Yue Hao, Xin Huang, Richard Smith and Brooke M Rock

Drug Metabolism and Disposition May 16, 2019, dmd.119.086967; DOI: https://doi.org/10.1124/dmd.119.086967
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Identification of Novel Metabolites of Vildagliptin in Rats: Thiazoline-Containing Thiol Adducts Formed via Cysteine or Glutathione Conjugation
Katsuhiko Mizuno, Kenji Takeuchi, Ken Umehara and Miki Nakajima

Drug Metabolism and Disposition May 16, 2019, dmd.119.086546; DOI: https://doi.org/10.1124/dmd.119.086546

May 15, 2019

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Enhanced platelet response to clopidogrel in Zucker diabetic fatty rats due to impaired clopidogrel inactivation by carboxylesterase 1 and increased exposure to active metabolite
Hongwei Yao, Ruifeng Bai, Tianming Ren, Yani Wang, Jingkai Gu and Yingjie Guo

Drug Metabolism and Disposition May 15, 2019, dmd.118.085126; DOI: https://doi.org/10.1124/dmd.118.085126

May 13, 2019

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Catalytic cleavage of disulfide bonds in small molecules and linkers of antibody- drug conjugates
Donglu Zhang, Aimee Fourie-O'Donohue, Peter S Dragovich, Thomas H Pillow, Jack D Sadowsky, Katherine R Kozak, Robert T Cass, Liling Liu, Yuzhong Deng, Yichin Liu, Cornelis ECA Hop and Siamak C Khojasteh

Drug Metabolism and Disposition May 13, 2019, dmd.118.086132; DOI: https://doi.org/10.1124/dmd.118.086132

May 10, 2019

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Carfilzomib is not an appropriate payload of antibody-drug conjugates due to rapid inactivation by lysosomal enzymes
Yong Ma, Josefa Dela Cruz-Chuh, S Cyrus Khojasteh, Peter S Dragovich, Thomas H Pillow and Donglu Zhang

Drug Metabolism and Disposition May 10, 2019, dmd.119.086595; DOI: https://doi.org/10.1124/dmd.119.086595
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The regional-specific relative and absolute expression of gut transporters in adult Caucasians: A meta-analysis
Matthew Harwood, Mian Zhang, Shriram Pathak and Sibylle Neuhoff

Drug Metabolism and Disposition May 10, 2019, dmd.119.086959; DOI: https://doi.org/10.1124/dmd.119.086959
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Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a prodrug of Exp3174 for Hypertension Treatment in Humans
Xiuli Li, Jingchao Sun, Zitao Guo, Dafang Zhong and Xiaoyan Chen

Drug Metabolism and Disposition May 10, 2019, dmd.118.085092; DOI: https://doi.org/10.1124/dmd.118.085092

May 08, 2019

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A systematic in vitro investigation of the inhibitor preincubation effect on multiple classes of clinically relevant transporters
Peter Tatrai, Patrick Schweigler, Birk Poller, Norbert Domange, Roelof de Wilde, Imad Hanna, Zsuzsanna Gaborik and Felix Huth

Drug Metabolism and Disposition May 8, 2019, dmd.118.085993; DOI: https://doi.org/10.1124/dmd.118.085993

May 02, 2019

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Regulatory recommendations for calculating the unbound maximum hepatic inlet concentration: A complicated story with a surprising and happy ending
Andrew Parkinson

Drug Metabolism and Disposition May 2, 2019, dmd.119.086496; DOI: https://doi.org/10.1124/dmd.119.086496

May 01, 2019

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Mechanisms Influencing The Disposition Of Monoclonal Antibodies And Peptides
Amita Datta-Mannan

Drug Metabolism and Disposition May 1, 2019, dmd.119.086488; DOI: https://doi.org/10.1124/dmd.119.086488

April 29, 2019

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Potential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization-Gas Chromatography
Kennerly S. Patrick and Wendy Rodriquez

Drug Metabolism and Disposition April 29, 2019, dmd.119.087189; DOI: https://doi.org/10.1124/dmd.119.087189

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