Evaluation of a Novel Renewable Hepatic Cell Model for Prediction of Clinical CYP3A4 Induction Using a Correlation-Based RIS Approach

Data Supplement

Files in this Data Supplement:

• Supplemental Tables -

  Supplemental Table 1 - Induction response in HepatoCells measured as CYP3A4 mRNA fold increase

  Supplemental Table 2 - Induction response in HepatoCells measured as CYP3A4 enzyme activity fold increase

  Supplemental Table 3 - Slope factors using Sigmoidal Hill 4 parameter function for curving fitting of concentration dependent induction response