Microvilli morphology can affect efflux active P-glycoprotein in confluent MDCKII-NKI_hMDR1 and Caco-2 cell monolayers

Data Supplement

Files in this Data Supplement:

• Supplemental Figures -

  Supplemental Figure 1 - Western blots of P-gp expression in the membrane extraction of MDCKII-hMDR1(A) and Caco-2 cells (B)

  Supplemental Figure 2 - Representative calibration curves over the concentration range 780 to 50000 pM for synthetic standard peptides AGAVAEEVLAAIR(A) and NTTGALTTR (B)

  Supplemental Figure 3 - Representations of arrangements and orientations employed for the simulations

  Supplemental Figure 4 - Examining the fraction of escapes from 107 independent particle emissions at various points along the microvillus at a separation distance of 0.3 mu-m