Influence of Zuojin Pill on the metabolism of venlafaxine in vitro and in rats and associated herb-drug interaction

Data Supplement

• Supplemental Data -

  Supplementary Table 1 - The contents of four alkaloids in Zuojin Pill.

  Supplementary Table 2 - Mass spectrometry parameters for measuring four major alkaloids of
  ZJP (berberine, coptisine, evodiamine, and rutaecarpine).

  Supplementary Table 3 - Intra- and inter-batch precision and accuracy of coptisine, berberine,
  evodiamine, and rutaecarpine in rat livers (Mean ±S.D., n = 5).

  Supplementary Table 4 - Stability of coptisine, berberine, evodiamine, and rutaecarpine in rat
  livers (Mean ±S.D., n = 3).

  Supplementary Table 5 - Intra-batch precision and accuracy of VEN, ODV, NDV, and NODV
  in rat livers (Mean ±S.D., n = 5).

  Supplementary Figure 1 - Inhibitory effects (IC50) of quinidine (A) and quinine (B) on ODV
  formation in HLM and RLM, respectively. Data were presented as mean ± S.D. in triplicates.