Data Supplement
- Supplemental Table 1 -
Supplemental Table S1. Proteins that co-immunoprecipitated with CYP1A2. Control rat liver microsomes immunoprecipitated with anti-CYP1A2 antibody, and co-immunoprecipitated proteins were identified by LC-MS. Lipid microdomain localization of these proteins were previously determined (Reed et al., 2022). Proteins are color-coded to describe their localization: black - predominantly disordered; red - uniformly distributed, green - predominantly ordered; purple with "?" - unknown as they were not detected in previous study. The abundance ratios and the associated p-values were determined in our previous study and were calculated using an Analysis of Variance (ANOVA) test. The p-value is a number between 0 and 1. A low p-value indicates a low probability that the null hypothesis is false and there is a "significant difference". The table also shows the Wiki and KEGG Pathway designations.
- Supplemental Table 2 -
Supplemental Table S2. Proteins that co-immunoprecipitated with CYP3A. PB rat liver microsomes immunoprecipitated with anti-CYP3A antibody, and co-immunoprecipitated proteins were identified by LC-MS. Lipid microdomain localization of these proteins were previously determined (Reed et al., 2022). Proteins are color-coded to describe their localization: black - predominantly disordered; red - uniformly distributed (abundance levels in supernatants and pellets derived from detergent solubilization of microsomes were not significantly different (Pvalue >0.05)), green - predominantly ordered; purple with "?" - unknown as they were not detected in previous study. The abundance ratios and the associated p-values were determined in our previous study and were calculated using an Analysis of Variance (ANOVA) test. The p-value is a number between 0 and 1. A low p-value indicates a low probability that the null hypothesis is false and there is a "significant difference". The table also shows the Wiki and KEGG Pathway designations.
- Supplemental Table 3 -
Supplemental Table S3. Proteins that were Co-immunoprecipitated with both anti-CYP1A2 and anti-CYP3A. This table is a subset of Supplemental Tables 1 and 2, and includes all the proteins that co-immunoprecipitated with both antibodies. The legend is as described as in Supplementary Table 1.