Table of Contents

Articles

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  Wuzhi Tablet (Schisandra Sphenanthera Extract) Protects against Acetaminophen-Induced Hepatotoxicity by Inhibition of CYP-Mediated Bioactivation and Regulation of NRF2-ARE and p53/p21 Pathways

  Xiaomei Fan, Yiming Jiang, Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Aijuan Qu, Frank J. Gonzalez, Min Huang and Huichang Bi

  Drug Metabolism and Disposition December 2014, 42 (12) 1982-1990; DOI: https://doi.org/10.1124/dmd.114.059535
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  Meta-Analysis of the Turnover of Intestinal Epithelia in Preclinical Animal Species and Humans

  Adam S. Darwich, Umair Aslam, Darren M. Ashcroft and Amin Rostami-Hodjegan

  Drug Metabolism and Disposition December 2014, 42 (12) 2016-2022; DOI: https://doi.org/10.1124/dmd.114.058404
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  Disposition and Metabolic Profiling of [¹⁴C]Cerlapirdine Using Accelerator Mass Spectrometry

  Susanna Tse, Louis Leung, Sangeeta Raje, Mark Seymour, Yoko Shishikura and R. Scott Obach

  Drug Metabolism and Disposition December 2014, 42 (12) 2023-2032; DOI: https://doi.org/10.1124/dmd.114.059675
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  Differential Expression of Drug Uptake and Efflux Transporters in Japanese Patients with Hepatocellular Carcinoma

  Tadashi Namisaki, Elke Schaeffeler, Hiroshi Fukui, Hitoshi Yoshiji, Yoshiyuki Nakajima, Peter Fritz, Matthias Schwab and Anne T. Nies

  Drug Metabolism and Disposition December 2014, 42 (12) 2033-2040; DOI: https://doi.org/10.1124/dmd.114.059832
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  Proton Pump Inhibitors Inhibit Methotrexate Transport by Renal Basolateral Organic Anion Transporter hOAT3

  Rym Chioukh, Marie-Sophie Noel-Hudson, Sandy Ribes, Natalie Fournier, Laurent Becquemont and Celine Verstuyft

  Drug Metabolism and Disposition December 2014, 42 (12) 2041-2048; DOI: https://doi.org/10.1124/dmd.114.058529
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  Aldehyde Oxidase Activity in Fresh Human Skin

  Nenad Manevski, Kamal Kumar Balavenkatraman, Barbara Bertschi, Piet Swart, Markus Walles, Gian Camenisch, Hilmar Schiller, Olivier Kretz, Barbara Ling, Reto Wettstein, Dirk J. Schaefer, Francois Pognan, Armin Wolf and Karine Litherland

  Drug Metabolism and Disposition December 2014, 42 (12) 2049-2057; DOI: https://doi.org/10.1124/dmd.114.060368
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  In Vitro Metabolism and Drug-Drug Interaction Potential of UTL-5g, a Novel Chemo- and Radioprotective Agent

  Jianmei Wu, Jiajiu Shaw, Sarah Dubaisi, Frederick Valeriote and Jing Li

  Drug Metabolism and Disposition December 2014, 42 (12) 2058-2067; DOI: https://doi.org/10.1124/dmd.114.060095
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  Paroxetine Markedly Increases Plasma Concentrations of Ophthalmic Timolol; CYP2D6 Inhibitors May Increase the Risk of Cardiovascular Adverse Effects of 0.5% Timolol Eye Drops

  Jukka Mäenpää, Marjo Volotinen-Maja, Hannu Kautiainen, Mikko Neuvonen, Mikko Niemi, Pertti J. Neuvonen and Janne T. Backman

  Drug Metabolism and Disposition December 2014, 42 (12) 2068-2076; DOI: https://doi.org/10.1124/dmd.114.059576
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  Effect of Prostaglandin E₂ on Multidrug Resistance Transporters In Human Placental Cells

  Clifford W. Mason, Gene T. Lee, Yafeng Dong, Helen Zhou, Lily He and Carl P. Weiner

  Drug Metabolism and Disposition December 2014, 42 (12) 2077-2086; DOI: https://doi.org/10.1124/dmd.114.059477
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  Mechanism-Based Inactivation of Human Cytochrome P450 3A4 by Two Piperazine-Containing Compounds

  Amanda K. Bolles, Rina Fujiwara, Erran D. Briggs, Amin A. Nomeir and Laura Lowe Furge

  Drug Metabolism and Disposition December 2014, 42 (12) 2087-2096; DOI: https://doi.org/10.1124/dmd.114.060459
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  Enhanced Methamphetamine Metabolism in Rhesus Macaque as Compared with Human: An Analysis Using a Novel Method of Liquid Chromatography with Tandem Mass Spectrometry, Kinetic Study, and Substrate Docking

  Ravinder Earla, Santosh Kumar, Lei Wang, Steven Bosinger, Junhao Li, Ankit Shah, Mohitkumar Gangwani, Anantha Nookala, Xun Liu, Lu Cao, Austin Jackson, Peter S. Silverstein, Howard S. Fox, Weihua Li and Anil Kumar

  Drug Metabolism and Disposition December 2014, 42 (12) 2097-2108; DOI: https://doi.org/10.1124/dmd.114.059378
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  An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver

  Yusuke Ito, Tatsuki Fukami, Tsuyoshi Yokoi and Miki Nakajima

  Drug Metabolism and Disposition December 2014, 42 (12) 2109-2116; DOI: https://doi.org/10.1124/dmd.114.059485